Design of a Thiol-Responsive, Traceless Prodrug with Rapid Self-Immolation for Cancer Chemotherapy

2021 ◽  
Author(s):  
Gengqi Liu ◽  
Zhen Jiang ◽  
Jonathan F. Lovell ◽  
Lei Zhang ◽  
Yumiao Zhang
Keyword(s):  
Cancer Chemotherapy ◽  
Self Immolation

Ecology, Dharma and Direct Action: A Brief Survey of Contemporary Eco-Buddhist Activism in Korea

2015 ◽  
Vol 31 (2) ◽  
pp. 293-311
Author(s):  
Young-Hae Yoon ◽  
Sherwin Jones
Keyword(s):  
Social Engagement ◽  
Direct Action ◽  
Social Activism ◽  
Turn Of The Millennium ◽  
Hunger Strike ◽  
Korean Society ◽  
High Profile ◽  
Reclamation Project ◽  
Self Immolation

Over the last few decades there has emerged a small, yet influential eco-Buddhism movement in South Korea which, since the turn of the millennium, has seen several S?n (J. Zen) Buddhist clerics engage in high-profile protests and activism campaigns opposing massive development projects which threatened widespread ecological destruction. This article will survey the issues and events surrounding three such protests; the 2003 samboilbae, or ‘threesteps- one-bow’, march led by Venerable Suky?ng against the Saemangeum Reclamation Project, Venerable Jiyul’s Anti-Mt. Ch?ns?ng tunnel hunger-strike campaign between 2002 and 2006, and lastly Venerable Munsu’s self-immolation protesting the Four Rivers Project in 2010. This article will additionally analyze the attempts by these clerics to deploy innovative and distinctively Buddhist forms of protest, the effects of these protests, and how these protests have altered public perceptions of the role of Buddhist clergy in Korean society. This study will additionally highlight issues relevant to the broader discourse regarding the intersection of Buddhism and social activism, such as the appropriation of traditional Buddhist practices as protest tactics and the potential for conflict between social engagement and the pursuit of Buddhist soteriological goals.

A Mechanism for Reversibly Pausing a Self-Immolation Cascade in Response to pH Changes

2019 ◽  
Author(s):  
Derrick Roberts ◽  
Ben S. Pilgrim ◽  
Tristan Dell ◽  
Molly Stevens
Keyword(s):  
Local Environment ◽  
Chemical Signals ◽  
Ph Sensitive ◽  
First Report ◽  
Ph Changes ◽  
Self Immolation

We describe the first report of a self-immolation cascade that can be reversibly paused and reactivated in response to pH changes. This system employs a triazole-based self-immolative linker, which expresses a pH-sensitive intermediate during its elimination sequence. This allows the system to respond to pH cues within its local environment, thus establishing a new way to gate self-immolative release using fluctuating or transient chemical signals.<br>

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