In Vivo Degradation Mechanism and Biocompatibility of a Biodegradable Aliphatic Polycarbonate: Poly(Trimethylene Carbonate-co-5-Hydroxy Trimethylene Carbonate)

2021 ◽  
Author(s):  
Sara Mohajeri ◽  
Brian G Amsden
Keyword(s):  
Degradation Mechanism ◽  
Trimethylene Carbonate ◽  
Aliphatic Polycarbonate ◽  
In Vivo Degradation

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis, Non-Acylating Performance and In Vivo Degradation

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1438
Author(s):  
Silvio Curia ◽  
Feifei Ng ◽  
Marie-Emérentienne Cagnon ◽  
Victor Nicoulin ◽  
Adolfo Lopez-Noriega
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Gel Chromatography ◽  
Amphiphilic Copolymers ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Acting ◽  
In Vivo Degradation

This article presents the evaluation of diblock and triblock poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-opening polymerisation. The concomitant formation of PTMC homopolymer could not be avoided irrespective of the catalyst amount, but the by-product could easily be removed by gel chromatography. Pure PEG-PTMCs undergo faster erosion in vivo than their corresponding homopolymer. Furthermore, these copolymers show outstanding stability compared to their polyester analogues when formulated with amine-containing reactive drugs, which makes them particularly suitable as LAIs for the sustained release of drugs susceptible to acylation.

Photo-Cross-Linked Poly(ethylene carbonate) Elastomers: Synthesis, in Vivo Degradation, and Determination of in Vivo Degradation Mechanism

2012 ◽  
Vol 13 (10) ◽  
pp. 3099-3107 ◽  
Author(s):  
L. A. Cornacchione ◽  
B. Qi ◽  
J. Bianco ◽  
Z. Zhou ◽  
B. G. Amsden
Keyword(s):  
Degradation Mechanism ◽  
Ethylene Carbonate ◽  
Poly Ethylene ◽  
In Vivo Degradation

In-vivo degradation mechanism of Ti-6Al-4V hip joints

2011 ◽  
Vol 31 (2) ◽  
pp. 120-127 ◽  
Author(s):  
Trine C. Lomholt ◽  
Karen Pantleon ◽  
Marcel A.J. Somers
Keyword(s):  
Degradation Mechanism ◽  
Hip Joints ◽  
In Vivo Degradation

scholarly journals The in Vitro and in Vivo Degradation of Cross-Linked Poly(trimethylene carbonate)-Based Networks

Polymers ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 151 ◽  
Author(s):  
Liqun Yang ◽  
Jianxin Li ◽  
Miao Li ◽  
Zhongwei Gu
Keyword(s):  
Trimethylene Carbonate ◽  
In Vivo Degradation

The in vitro and in vivo degradation behavior of poly (trimethylene carbonate-co-ε-caprolactone) implants

Polymer ◽  
2014 ◽  
Vol 55 (20) ◽  
pp. 5111-5124 ◽  
Author(s):  
Liqun Yang ◽  
Jianxin Li ◽  
Shu Meng ◽  
Ying Jin ◽  
Jinzhe Zhang ◽  
...  
Keyword(s):  
Degradation Behavior ◽  
Trimethylene Carbonate ◽  
In Vivo Degradation
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