Manganese-Doped Carbon Dots with Redshifted Orange Emission for Enhanced Fluorescence and Magnetic Resonance Imaging

2021 ◽  
Vol 4 (2) ◽  
pp. 1969-1975
Author(s):  
Sijia Sun ◽  
Lining Zhao ◽  
Di Wu ◽  
Hongxin Zhang ◽  
Haichen Lian ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Carbon Dots ◽  
Resonance Imaging ◽  
Enhanced Fluorescence ◽  
Orange Emission ◽  
Doped Carbon Dots

Engineered gadolinium-doped carbon dots for magnetic resonance imaging-guided radiotherapy of tumors

Biomaterials ◽  
2017 ◽  
Vol 121 ◽  
pp. 109-120 ◽  
Author(s):  
Fengyi Du ◽  
Lirong Zhang ◽  
Li Zhang ◽  
Miaomiao Zhang ◽  
Aihua Gong ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Carbon Dots ◽  
Resonance Imaging ◽  
Doped Carbon Dots

scholarly journals NIR-laser-triggered gadolinium-doped carbon dots for magnetic resonance imaging, drug delivery and combined photothermal chemotherapy for triple negative breast cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Qunjiao Jiang ◽  
Li Liu ◽  
Qiuying Li ◽  
Yi Cao ◽  
Dong Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Triple Negative Breast Cancer ◽  
Carbon Dots ◽  
Triple Negative ◽  
Resonance Imaging ◽  
Doped Carbon Dots ◽  
Nir Laser

Abstract Background Owing to high genetic diversities of tumor cells and low response rate of standard chemotherapy, patients with triple negative breast cancer (TNBC) have short progression-free survivals and poor outcomes, which need to explore an effective approach to improve therapeutic efficacy. Methods Novel gadolinium doped carbon dots (Gd@CDs) have been designed and prepared through hydrothermal method with 3,4-dihydroxyhydrocinnamic acid, 2,2′-(ethylenedioxy)bis(ethylamine) and gadolinium chloride. The synthesized nanostructures were characterized. Taking advantage of good biocompatibility of Gd@CDs, a nanoplatform based on Gd@CDs has been developed to co-deliver chemotherapy drug doxorubicin hydrochloride (Dox) and a near-infrared (NIR) photothermal agent, IR825 for magnetic resonance imaging (MRI) guided photothermal chemotherapy for TNBC. Results The as-synthesized Dox@IR825@Gd@CDs displayed favorable MRI ability in vivo. Upon NIR laser irradiation, Dox@IR825@Gd@CDs could convert the NIR light to heat and efficiently inhibit tumor growth through photothermal chemotherapy in vitro and in vivo. Additionally, the impact of photothermal chemotherapy on the murine motor coordination was assessed by rotarod test. Dox@IR825@Gd@CDs presented low toxicity and high photothermal chemotherapy efficiency. Conclusion A noble theranostic nanoplatform (Dox@IR825@Gd@CDs) was developed that could be tailored to achieve loading of Dox and IR825, intracellular delivery, favorable MRI, excellent combination therapy with photothermal therapy and chemotherapy to enhance therapeutic effect against TNBC cells. This study will provide a promising strategy for the development of Gd-based nanomaterials for MRI and combinational therapy for TNBC. Graphic abstract

scholarly journals Manganese-Doped N-Hydroxyphthalimide-Derived Carbon Dots—Theranostics Applications in Experimental Breast Cancer Models

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1982
Author(s):  
Adrian Tiron ◽  
Corneliu S. Stan ◽  
Gabriel Luta ◽  
Cristina M. Uritu ◽  
Irina-Cezara Vacarean-Trandafir ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cell Viability ◽  
Carbon Dots ◽  
Resonance Imaging ◽  
Primary Tumors ◽  
Cancer Models ◽  
Doped Carbon Dots

Background: Theranostics, a novel concept in medicine, is based on the use of an agent for simultaneous diagnosis and treatment. Nanomaterials provide promising novel approaches to theranostics. Carbon Dots have been shown to exhibit anti-tumoral properties in various cancer models. The aim of the present study is to develop gadolinium, Fe3+, and Mn2+-doped N-hydroxyphthalimide-derived Carbon Dots. The resulted doped Carbon Dots should preserve the anti-tumoral properties while gaining magnetic resonance imaging properties. Methods: Normal and cancer cell lines have been treated with doped Carbon Dots, and the cell viability has been measured. The doped Carbon Dots that exhibited the most prominent anti-tumoral effect accompanied by the lowest toxicity have been further in vivo tested. Magnetic resonance imaging evaluates both in vitro and in vivo the possibility of using doped Carbon Dots as a contrast agent. Results: According to the results obtained from both the in vitro and in vivo experimental models used in our study, Mn2+-doped Carbon Dots (Mn-CDs-NHF) exhibit anti-tumoral properties, do not significantly impair the cell viability of normal cells, and reduce lung metastasis and the volume of mammary primary tumors while allowing magnetic resonance imaging. Conclusions: Our findings prove that Mn-CDs-NHF can be used as theranostics agents in pre-clinical models.

A combination of super-resolution fluorescence and magnetic resonance imaging using a Mn(ii) compound

2019 ◽  
Vol 6 (10) ◽  
pp. 2914-2920 ◽  
Author(s):  
Xiaohe Tian ◽  
Lufei Xiao ◽  
Yu Shen ◽  
Lei Luo ◽  
Guilong Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Super Resolution ◽  
Resonance Imaging ◽  
Enhanced Fluorescence ◽  
Two Photon ◽  
Magnetic Contrast ◽  
Photon Signal

Two manganese(ii) complexes supported by terpyridyl-based ligands were synthesized; they showed an enhanced fluorescence, including a two-photon signal and magnetic contrast, and were used in multi-modal imaging.

Routes to Potentially Safer T1 Magnetic Resonance Imaging Contrast in a Compact Plasmonic Nanoparticle with Enhanced Fluorescence

ACS Nano ◽  
2018 ◽  
Vol 12 (8) ◽  
pp. 8214-8223 ◽  
Author(s):  
Luke Henderson ◽  
Oara Neumann ◽  
Caterina Kaffes ◽  
Runmin Zhang ◽  
Valeria Marangoni ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Enhanced Fluorescence ◽  
Plasmonic Nanoparticle ◽  
Magnetic Resonance Imaging Contrast

Bevacizumab and folic acid dual-targeted gadolinium-carbon dots for fluorescence/magnetic resonance imaging of hepatocellular carcinoma

2021 ◽  
Vol 61 ◽  
pp. 102288
Author(s):  
Fatemeh Maghsoudinia ◽  
Mohamad Bagher Tavakoli ◽  
Roghayeh Kamran Samani ◽  
Hasan Motaghi ◽  
Seyed Hossein Hejazi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Hepatocellular Carcinoma ◽  
Folic Acid ◽  
Magnetic Resonance ◽  
Carbon Dots ◽  
Resonance Imaging

Multifunctional red carbon dots: a theranostic platform for magnetic resonance imaging and fluorescence imaging-guided chemodynamic therapy

The Analyst ◽  
2020 ◽  
Vol 145 (10) ◽  
pp. 3592-3597
Author(s):  
Wentao Wang ◽  
Qicheng Zhang ◽  
Ming Zhang ◽  
Yihan Liu ◽  
Jian Shen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cancer Therapy ◽  
Fluorescence Imaging ◽  
Carbon Dots ◽  
Resonance Imaging

In recent years, carbon dots (CDs) with red-emitting wavelengths have received increasing attention in cancer therapy and imaging.

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