Calcium-bisphosphonate Nanoparticle Platform as a Prolonged Nanodrug and Bone-Targeted Delivery System for Bone Diseases and Cancers

2021 ◽  
Vol 4 (3) ◽  
pp. 2490-2501
Author(s):  
Yanling Lin ◽  
Maria G. Villacanas ◽  
Hong Zou ◽  
Hangrui Liu ◽  
Ines G. Carcedo ◽  
...  
Keyword(s):  
Delivery System ◽  
Targeted Delivery ◽  
Bone Diseases ◽  
Targeted Delivery System

Targeted delivery system using silica nanoparticles coated with chitosan and AS1411 for combination therapy of doxorubicin and antimiR-21

2021 ◽  
pp. 118111
Author(s):  
Fatemeh Khatami ◽  
Maryam M. Matin ◽  
Noor Mohammad Danesh ◽  
Ahmad Reza Bahrami ◽  
Khalil Abnous ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Silica Nanoparticles ◽  
Delivery System ◽  
Targeted Delivery ◽  
Targeted Delivery System

Targeted Delivery System Based on Gemcitabine-Loaded Silk Fibroin Nanoparticles for Lung Cancer Therapy

2017 ◽  
Vol 9 (37) ◽  
pp. 31600-31611 ◽  
Author(s):  
Fatemeh Mottaghitalab ◽  
Melika Kiani ◽  
Mehdi Farokhi ◽  
Subhas C. Kundu ◽  
Rui L. Reis ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Therapy ◽  
Silk Fibroin ◽  
Delivery System ◽  
Targeted Delivery ◽  
Silk Fibroin Nanoparticles ◽  
Lung Cancer Therapy ◽  
Targeted Delivery System

Melanoma-targeted delivery system (part 1): Design, synthesis and evaluation of releasable disulfide drug by glutathione

2015 ◽  
Vol 101 ◽  
pp. 668-680 ◽  
Author(s):  
Radhia El Aissi ◽  
Jean-Michel Chezal ◽  
Sébastien Tarrit ◽  
Olivier Chavignon ◽  
Emmanuel Moreau
Keyword(s):  
Delivery System ◽  
Targeted Delivery ◽  
Design Synthesis ◽  
System Part ◽  
Targeted Delivery System

Intracellular Fate of a Targeted Delivery System

2008 ◽  
Vol 4 (4) ◽  
pp. 508-514 ◽  
Author(s):  
Chitta Ranjan Patra ◽  
Sheng Cao ◽  
Stephanie Safgren ◽  
Resham Bhattacharya ◽  
Matthew M. Ames ◽  
...  
Keyword(s):  
Delivery System ◽  
Targeted Delivery ◽  
Intracellular Fate ◽  
Targeted Delivery System

Abstract LB-A16: Imaging of glioblastoma using LDLR-based targeted delivery system

2019 ◽  
Author(s):  
Izabela Tworowska ◽  
Leo G Flores II ◽  
Rafal Zielinski ◽  
Jonathan Nowak ◽  
Pascaline Lecorche ◽  
...  
Keyword(s):  
Delivery System ◽  
Targeted Delivery ◽  
Targeted Delivery System

scholarly journals Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

Pharmaceutics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 70 ◽  
Author(s):  
Khaled AbouAitah ◽  
Agata Stefanek ◽  
Iman M. Higazy ◽  
Magdalena Janczewska ◽  
Anna Swiderska-Sroda ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Folic Acid ◽  
Cancer Cells ◽  
Delivery System ◽  
Targeted Delivery ◽  
Gum Arabic ◽  
Colon Cancer Cells ◽  
Hydroxyapatite Nanoparticles ◽  
Anticancer Effects ◽  
Targeted Delivery System

Targeted drug delivery offers great opportunities for treating cancer. Here, we developed a novel anticancer targeted delivery system for piperine (Pip), an alkaloid prodrug derived from black pepper that exhibits anticancer effects. The tailored delivery system comprises aggregated hydroxyapatite nanoparticles (HAPs) functionalized with phosphonate groups (HAP-Ps). Pip was loaded into HAPs and HAP-Ps at pH 7.2 and 9.3 to obtain nanoformulations. The nanoformulations were characterized using several techniques and the release kinetics and anticancer effects investigated in vitro. The Pip loading capacity was >20%. Prolonged release was observed with kinetics dependent on pH, surface modification, and coating. The nanoformulations fully inhibited monolayer HCT116 colon cancer cells compared to Caco2 colon cancer and MCF7 breast cancer cells after 72 h, whereas free Pip had a weaker effect. The nanoformulations inhibited ~60% in HCT116 spheroids compared to free Pip. The Pip-loaded nanoparticles were also coated with gum Arabic and functionalized with folic acid as a targeting ligand. These functionalized nanoformulations had the lowest cytotoxicity towards normal WI-38 fibroblast cells. These preliminary findings suggest that the targeted delivery system comprising HAP aggregates loaded with Pip, coated with gum Arabic, and functionalized with folic acid are a potentially efficient agent against colon cancer.

Rod-Scale Design Strategies for Immune-Targeted Delivery System toward Cancer Immunotherapy

ACS Nano ◽  
2019 ◽  
Vol 13 (7) ◽  
pp. 7705-7715 ◽  
Author(s):  
Xiupeng Wang ◽  
Shu Ihara ◽  
Xia Li ◽  
Atsuo Ito ◽  
Yu Sogo ◽  
...  
Keyword(s):  
Cancer Immunotherapy ◽  
Delivery System ◽  
Targeted Delivery ◽  
Design Strategies ◽  
Scale Design ◽  
Targeted Delivery System
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