Mechanochemical Drug Conjugation via pH-Responsive Imine Linkage for Polyether Prodrug Micelles

2021 ◽  
Author(s):  
Sohee Han ◽  
Joonhee Lee ◽  
Eunkyeong Jung ◽  
Suebin Park ◽  
Aoi Sagawa ◽  
...  
Keyword(s):  
Ph Responsive ◽  
Drug Conjugation

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

A fast response, large deformation, excellent mechanical pH-responsive polyacrylonitrile/polyimide bilayer film

Polymer ◽  
2020 ◽  
Vol 191 ◽  
pp. 122271
Author(s):  
Xu Wang ◽  
Chengyong He ◽  
Longbo Luo ◽  
Daiqiang Chen ◽  
Xiangyang Liu ◽  
...  
Keyword(s):  
Large Deformation ◽  
Fast Response ◽  
Bilayer Film ◽  
Ph Responsive

Electrophoretic deposition of GHK-Cu loaded MSN-chitosan coatings with pH-responsive release of copper and its bioactivity

2019 ◽  
Vol 104 ◽  
pp. 109746 ◽  
Author(s):  
Cui Ning ◽  
Jing Jiajia ◽  
Li Meng ◽  
Qi Hongfei ◽  
Wu Xianglong ◽  
...  
Keyword(s):  
Electrophoretic Deposition ◽  
Ph Responsive

Synthesis of pH-responsive triazine skeleton nano-polymer composite containing AIE group for drug delivery

2021 ◽  
Author(s):  
Yifan Zhang ◽  
Xueying Peng ◽  
Xinbo Jing ◽  
Lin Cui ◽  
Shengchao Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Composite ◽  
Ph Responsive
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