Gelatin/Oxidized Konjac Glucomannan Composite Hydrogels with High Resistance to Large Deformation for Tissue Engineering Applications

2021 ◽  
Vol 4 (2) ◽  
pp. 1536-1543
Author(s):  
Yongchao Jiang ◽  
Gaiying Li ◽  
Jie Liu ◽  
Mengya Li ◽  
Qian Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Large Deformation ◽  
High Resistance ◽  
Konjac Glucomannan ◽  
Engineering Applications ◽  
Composite Hydrogels ◽  
Oxidized Konjac Glucomannan

scholarly journals Pullulan/Poly(Vinyl Alcohol) Composite Hydrogels for Adipose Tissue Engineering

Materials ◽  
2019 ◽  
Vol 12 (19) ◽  
pp. 3220
Author(s):  
Iuliana Samoila ◽  
Sorina Dinescu ◽  
Gratiela Gradisteanu Pircalabioru ◽  
Luminita Marutescu ◽  
Gheorghe Fundueanu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vinyl Alcohol ◽  
Adipogenic Differentiation ◽  
Poly Vinyl Alcohol ◽  
Dissolution Behavior ◽  
Swelling Kinetics ◽  
Chemical Crosslinking ◽  
Engineering Applications ◽  
Composite Hydrogels ◽  
Adipose Tissue Engineering

Composite hydrogels based on pullulan (HP) and poly(vinyl alcohol) (PVA) were both prepared by simple chemical crosslinking with sodium trimethaphosphate (STMP) or by dual crosslinking (simultaneously chemical crosslinking with STMP and physical crosslinking by freeze-thaw technique). The resulting hydrogels and cryogels were designed for tissue engineering applications. PVA, with two different molecular weights (47,000 and 125,000 g/mol; PVA47 and PVA125, respectively), as well as different P/PVA weight ratios were tested. The physico-chemical characterization of the hydrogels was performed by FTIR spectroscopy and scanning electron microscopy (SEM). The swelling kinetics, dissolution behavior, and degradation profiles in simulated physiological conditions (phosphate buffer at pH 7.4) were investigated. Pullulan concentration and the crosslinking method had significant effects on the pore size, swelling ratio, and degradation profiles. Cryogels exhibit lower swelling capacities than the conventional hydrogels but have better stability against hydrolitic degradation. Biocompatibility of the hydrogels was also investigated by both MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and LDH (lactaten dehydrogenase) assay. The MTT and LDH assays proved that dual crosslinked HP/PVA125 (75:25, w/w) scaffolds are more biocompatible and promote to a greater extent the adhesion and proliferation of L929 murine fibroblast cells than chemically crosslinked HP/PVA47 (50/50, w/w) scaffolds. Moreover, the HP/PVA125 cryogel had the best ability for the adipogenic differentiation of cells. The overall results demonstrated that the HP/PVA composite hydrogels or cryogels are suitable biomaterials for tissue engineering applications.

Fabrication of chitosan/poly(ε-caprolactone) composite hydrogels for tissue engineering applications

2010 ◽  
Vol 22 (2) ◽  
pp. 279-288 ◽  
Author(s):  
Xia Zhong ◽  
Chengdong Ji ◽  
Andrew K. L. Chan ◽  
Sergei G. Kazarian ◽  
Andrew Ruys ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Engineering Applications ◽  
Composite Hydrogels

Polysaccharide-Based Nanobiomaterials as Controlled Release Systems for Tissue Engineering Applications

2015 ◽  
Vol 21 (33) ◽  
pp. 4837-4850 ◽  
Author(s):  
Eustolia Rodriguez-Velazquez ◽  
Manuel Alatorre-Meda ◽  
Joao F. Mano
Keyword(s):  
Tissue Engineering ◽  
Controlled Release ◽  
Engineering Applications
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