A Dexamethasone-Eluting Porous Scaffold for Bone Regeneration Fabricated by Selective Laser Sintering

2020 ◽  
Vol 3 (12) ◽  
pp. 8739-8747
Author(s):  
Zhidong Sun ◽  
Fan Wu ◽  
Huichang Gao ◽  
Kai Cui ◽  
Mengyue Xian ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Porous Scaffold ◽  
Selective Laser Sintering ◽  
Laser Sintering

Fabrication of Polycaprolactone Bone Tissue Engineering Scaffolds Using Selective Laser Sintering

2004 ◽  
Author(s):  
Brock Partee ◽  
Scott J. Hollister ◽  
Suman Das
Keyword(s):  
Tissue Engineering ◽  
Human Tissue ◽  
Cell Attachment ◽  
Porous Scaffold ◽  
Selective Laser Sintering ◽  
Laser Sintering ◽  
Processing Parameter ◽  
Tissue Engineering Scaffolds ◽  
Porous Architecture ◽  
Regenerate Tissue

Tissue engineering combines principles of the life sciences and engineering to replace and repair damaged human tissue. Present practice generally requires the use of porous, bioresorbable scaffolds to serve as temporary 3D templates to guide cell attachment, differentiation, proliferation, and subsequent regenerate tissue formation. Such scaffolds are anticipated to play an important role in allowing physicians to simultaneously reconstruct and regenerate damaged human tissue such as bone, cartilage, ligament and tendon. Recent research strongly suggests the choice of scaffold material and its internal porous architecture significantly influence regenerate tissue structure and function. However, a lack of versatile biomaterials processing and fabrication methods capable of meeting the complex geometric and compositional requirements of tissue engineering scaffolds has slowed progress towards fully testing these promising findings. It is widely accepted that layered manufacturing methods such as selective laser sintering (SLS) have the potential to fulfill these needs. Our research aims to investigate the viability of using SLS to fabricate tissue engineering scaffolds composed of polycaprolactone (PCL), one of the most widely investigated biocompatible, bioresorbable materials for tissue engineering applications. In this work, we report our recent progress on porous scaffold design and fabrication, optimal SLS processing parameter development using systematic factorial design of experiments, and structural characterization via optical microscopy.

Selective Laser Sintering of Tissue Engineering Scaffolds Using Poly(L-Lactide) Microspheres

2007 ◽  
Vol 334-335 ◽  
pp. 1225-1228 ◽  
Author(s):  
Wen You Zhou ◽  
S.H. Lee ◽  
Min Wang ◽  
W.L. Cheung
Keyword(s):  
Tissue Engineering ◽  
Porous Scaffold ◽  
Selective Laser Sintering ◽  
Laser Sintering ◽  
Porous Scaffolds ◽  
Tissue Engineering Scaffolds ◽  
Water Emulsion ◽  
Bed Temperature ◽  
Oil In Water Emulsion ◽  
Polyamide Powder

This paper reports a study on the modification of a commercial selective laser sintering (SLS) machine for the fabrication of tissue engineering scaffolds from small quantities of poly(L-lactide) (PLLA) microspheres. A miniature build platform was designed, fabricated and installed in the build cylinder of a Sinterstation 2000 system. Porous scaffolds in the form of rectangular prism, 12.7×12.7×25.4 mm3, with interconnected square and round channels were designed using SolidWorks. For initial trials, DuraFormTM polyamide powder was used to build scaffolds with a designed porosity of ~70%. The actual porosity was found to be ~83%, which indicated that the sintered regions were not fully dense. PLLA microspheres in the size range of 5-30 μm were made using an oil-in-water emulsion solvent evaporation procedure and they were suitable for the SLS process. A porous scaffold was sintered from the PLLA microspheres with a laser power of 15W and a part bed temperature of 60oC. SEM examination showed that the PLLA microspheres were partially melted to form the scaffold. This study has demonstrated that it is feasible to build tissue engineering scaffolds from small amounts of biomaterials using a commercial SLS machine with suitable modifications.

In vitrobioactivity and degradability of β-tricalcium phosphate porous scaffold fabricated via selective laser sintering

2013 ◽  
Vol 60 (2) ◽  
pp. 266-273 ◽  
Author(s):  
Cijun Shuai ◽  
Jingyu Zhuang ◽  
Huanlong Hu ◽  
Shuping Peng ◽  
Defu Liu ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
Porous Scaffold ◽  
Selective Laser Sintering ◽  
Laser Sintering

scholarly journals Bioactive Tetracalcium Phosphate Scaffolds Fabricated by Selective Laser Sintering for Bone Regeneration Applications

Materials ◽  
2020 ◽  
Vol 13 (10) ◽  
pp. 2268 ◽  
Author(s):  
Tian Qin ◽  
Xiaoqian Li ◽  
Hui Long ◽  
Shizhen Bin ◽  
Yong Xu
Keyword(s):  
Mechanical Properties ◽  
Bone Regeneration ◽  
Laser Power ◽  
Selective Laser Sintering ◽  
Three Dimensional ◽  
Laser Sintering ◽  
Scaffold Material ◽  
Promising Candidate ◽  
Tetracalcium Phosphate ◽  
Good Biocompatibility

Tetracalcium phosphate (TTCP), a potential biological scaffold material, has attracted increasing interest for bone regeneration applications due to its good biodegradability and biocompatibility. In this research, three-dimensional porous TTCP scaffolds were manufactured via selective laser sintering (SLS), and an in-depth and meticulous study on the influence of laser power on the microstructure and mechanical properties of TTCP scaffolds was performed. The results showed that the TTCP particles fused together and formed a solid object due to the decrease in the number of micro-pores in the scaffold as the laser power increased from 6 W to 9 W. The maximum compressive strength that the scaffold could withstand and the strength of the fracture toughness were 11.87 ± 0.64 MPa and 1.12 ± 0.1 MPa·m1/2, respectively. When the laser power increased from 9 W to 10 W, the TTCP grains grew abnormally, resulting in diminished mechanical properties. The bioactivity tests showed that the surfaces of the scaffolds were entirely covered by bone-like apatite layers after soaking in simulated body fluid (SBF) for three days, indicating that the scaffolds exhibit excellent bioactivity. Moreover, cell experiments showed that the TTCP scaffolds had good biocompatibility. This study indicated that SLS-fabricated TTCP scaffolds may be a promising candidate for bone regeneration applications.

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