Selectivity Comparison of Tumor-Imaging Probes Designed Based on Various Tumor-Targeting Strategies: A Proof of Concept Study

2020 ◽  
Author(s):  
Rui-Ying Guo ◽  
Han-Min Wang ◽  
Xiaowu Dong ◽  
Yongzhou Hu ◽  
Jia Li ◽  
...  
Keyword(s):  
Tumor Targeting ◽  
Tumor Imaging ◽  
Proof Of Concept ◽  
Concept Study ◽  
Imaging Probes

scholarly journals Investigation of Specific Targeting of Triptorelin-Conjugated Dextran-Coated Magnetite Nanoparticles as a Targeted Probe in GnRH+ Cancer Cells in MRI

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Milad Yousefvand ◽  
Zahra Mohammadi ◽  
Farzaneh Ghorbani ◽  
Rasoul Irajirad ◽  
Hormoz Abedi ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Tumor Targeting ◽  
Tumor Imaging ◽  
Superparamagnetic Iron Oxide ◽  
Gnrh Receptors ◽  
Imaging Probes ◽  
Magnetic Resonance Imaging Mri ◽  
Targeted Contrast Agent

In recent years, the conjugation of superparamagnetic iron oxide nanoparticles (SPIONs), as tumor-imaging probes for magnetic resonance imaging (MRI), with tumor targeting peptides possesses promising advantages for specific delivery of MRI agents. The objective of the current study was to design a targeted contrast agent for MRI based on Fe3O4 nanoparticles conjugated triptorelin (SPION@triptorelin), which has a great affinity to the GnRH receptors. The SPIONs-coated carboxymethyl dextran (SPION@CMD) conjugated triptorelin (SPION@CMD@triptorelin) were synthesized using coprecipitation method and characterized by DLS, TEM, XRD, FTIR, Zeta, and VSM techniques. The relaxivities of synthetized formulations were then calculated using a 1.5 Tesla clinical magnetic field. MRI, quantitative cellular uptake, and cytotoxicity level of them were estimated. The characterization results confirmed that the formation of SPION@CMD@triptorelin has been conjugated with a suitable size. Our results demonstrated the lack of cellular cytotoxicity of SPION@CMD@triptorelin, and it could increase the cellular uptake of SPIONs to MDA-MB-231 cancer cells 6.50-fold greater than to SPION@CMD at the concentration of 75 μM. The relaxivity calculations for SPION@CMD@triptorelin showed a suitable r2 and r2/r1 with values of 31.75 mM−1·s−1 and 10.26, respectively. Our findings confirm that triptorelin-targeted SPIONs could provide a T2-weighted probe contrast agent that has the great potential for the diagnosis of GnRH-positive cancer in MRI.

scholarly journals Multimerization results in formation of re-bindable metabolites: A proof of concept study with FSC-based minigastrin imaging probes targeting CCK2R expression

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0201224 ◽  
Author(s):  
Dominik Summer ◽  
Andrea Kroess ◽  
Rudolf Woerndle ◽  
Christine Rangger ◽  
Maximilian Klingler ◽  
...  
Keyword(s):  
Proof Of Concept ◽  
Concept Study ◽  
Imaging Probes

scholarly journals Real-time Brain Tumor imaging with endogenous fluorophores: a diagnosis proof-of-concept study on fresh human samples

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Fanny Poulon ◽  
Johan Pallud ◽  
Pascale Varlet ◽  
Marc Zanello ◽  
Fabrice Chretien ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Real Time ◽  
Tumor Imaging ◽  
Proof Of Concept ◽  
Concept Study ◽  
Human Samples ◽  
Endogenous Fluorophores

Tumor-Targeting Peptides: Ligands for Molecular Imaging and Therapy

2018 ◽  
Vol 18 (1) ◽  
pp. 74-86 ◽  
Author(s):  
Ning Zhao ◽  
Yeshan Qin ◽  
Hongguang Liu ◽  
Zhen Cheng
Keyword(s):  
Clinical Trials ◽  
Tumor Cells ◽  
Tumor Targeting ◽  
Tumor Imaging ◽  
Therapeutic Agents ◽  
Cure Rate ◽  
High Affinity ◽  
Tumor Diagnostics ◽  
Tumor Tissues ◽  
Imaging Probes

The aberrant proliferation of tumor cells and abundant vasculature in tumor tissues are closely correlated with receptors that are specifically dysregulated in tumor cells. These tumor-associated targets are critical in early diagnosis and therapy selection. Ligands such as antibodies, proteins, polypeptides and polysaccharides that specifically bind to these targets can significantly improve the detection and cure rate when used as tumor imaging probes or anti-tumor agents. Compared to other targeting ligands, peptides have attracted increasingly more attention in tumor diagnostics and therapeutics because of their small sizes, high affinity, stability, ease of modification and low immunogenicity. Several peptide-based imaging probes and therapeutic agents have already been used in clinical trials. This review summarizes some of the tumor-associated targets and their corresponding peptides, as well as the potential of these peptides in cancer treatment.

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