Biodegradable Hollow Manganese Silicate Nanocomposites to Alleviate Tumor Hypoxia toward Enhanced Photodynamic Therapy

2020 ◽  
Vol 3 (11) ◽  
pp. 7989-7999
Author(s):  
Md Nafiujjaman ◽  
Seock-Jin Chung ◽  
Irina Kalashnikova ◽  
Meghan L. Hill ◽  
Silver Homa ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Hypoxia ◽  
Manganese Silicate ◽  
Silicate Nanocomposites

Upconversion Composite Nanoparticles for Tumor Hypoxia Modulation and Enhanced Near-Infrared-Triggered Photodynamic Therapy

2018 ◽  
Vol 10 (18) ◽  
pp. 15494-15503 ◽  
Author(s):  
Tongxu Gu ◽  
Liang Cheng ◽  
Fei Gong ◽  
Jun Xu ◽  
Xiang Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Tumor Hypoxia ◽  
Composite Nanoparticles

Responsive agarose hydrogel incorporated with natural humic acid and MnO2 nanoparticles for effective relief of tumor hypoxia and enhanced photo-induced tumor therapy

2020 ◽  
Vol 8 (1) ◽  
pp. 353-369 ◽  
Author(s):  
Mengmeng Hou ◽  
Weiwei Liu ◽  
Lei Zhang ◽  
Leiyang Zhang ◽  
Zhigang Xu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Humic Acid ◽  
Tumor Microenvironment ◽  
Tumor Therapy ◽  
Tumor Hypoxia ◽  
Therapeutic Outcome ◽  
Severe Hypoxia ◽  
Tumor Penetration ◽  
Mno2 Nanoparticles ◽  
Agarose Hydrogel

In spite of widespread applications of nano-photosensitizers, poor tumor penetration and severe hypoxia in the tumor microenvironment (TME) always result in an undesirable therapeutic outcome of photodynamic therapy (PDT).

Investigation of PPIX-Lipo-MnO2 to enhance photodynamic therapy by improving tumor hypoxia

2019 ◽  
Vol 104 ◽  
pp. 109979 ◽  
Author(s):  
Lalit Chudal ◽  
Nil Kanatha Pandey ◽  
Jonathan Phan ◽  
Omar Johnson ◽  
Xiuying Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Hypoxia

Nanomaterials to relieve tumor hypoxia for enhanced photodynamic therapy

Nano Today ◽  
2020 ◽  
Vol 35 ◽  
pp. 100960 ◽  
Author(s):  
Cheng Zhang ◽  
Wen-Jun Qin ◽  
Xue-Feng Bai ◽  
Xian-Zheng Zhang
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Hypoxia

scholarly journals Phospholipid membrane-decorated deep-penetrated nanocatalase relieve tumor hypoxia to enhance chemo-photodynamic therapy

2020 ◽  
Vol 10 (11) ◽  
pp. 2246-2257 ◽  
Author(s):  
Junjing Yin ◽  
Haiqiang Cao ◽  
Hong Wang ◽  
Kaoxiang Sun ◽  
Yaping Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Hypoxia ◽  
Phospholipid Membrane

Liposomes co-loaded with metformin and chlorin e6 modulate tumor hypoxia during enhanced photodynamic therapy

Nano Research ◽  
2016 ◽  
Vol 10 (4) ◽  
pp. 1200-1212 ◽  
Author(s):  
Xuejiao Song ◽  
Liangzhu Feng ◽  
Chao Liang ◽  
Min Gao ◽  
Guosheng Song ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Hypoxia ◽  
Chlorin E6

scholarly journals Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

Biomolecules ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 81
Author(s):  
Liang Hong ◽  
Jiangmin Li ◽  
Yali Luo ◽  
Tao Guo ◽  
Chenshuang Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Treatment Modality ◽  
Tumor Metastasis ◽  
State Of The Art ◽  
Tumor Hypoxia ◽  
Future Research ◽  
Tumor Resistance ◽  
Normal Tissues ◽  
Recent Advances

Photodynamic therapy (PDT) is a treatment modality that uses light to target tumors and minimize damage to normal tissues. It offers advantages including high spatiotemporal selectivity, low side effects, and maximal preservation of tissue functions. However, the PDT efficiency is severely impeded by the hypoxic feature of tumors. Moreover, hypoxia may promote tumor metastasis and tumor resistance to multiple therapies. Therefore, addressing tumor hypoxia to improve PDT efficacy has been the focus of antitumor treatment, and research on this theme is continuously emerging. In this review, we summarize state-of-the-art advances in strategies for overcoming hypoxia in tumor PDTs, categorizing them into oxygen-independent phototherapy, oxygen-economizing PDT, and oxygen-supplementing PDT. Moreover, we highlight strategies possessing intriguing advantages such as exceedingly high PDT efficiency and high novelty, analyze the strengths and shortcomings of different methods, and envision the opportunities and challenges for future research.

PCN-Fe(III)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia

Nano Research ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 273-281 ◽  
Author(s):  
Tao Zhang ◽  
Zhenqi Jiang ◽  
Libin Chen ◽  
Chunshu Pan ◽  
Shan Sun ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Photodynamic Therapy ◽  
High Efficiency ◽  
Tumor Hypoxia ◽  
Mri Guided
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