Modulation of Amyloid Protein Fibrillation by Synthetic Polymers: Recent Advances in the Context of Neurodegenerative Diseases

2020 ◽  
Vol 3 (10) ◽  
pp. 6598-6625 ◽  
Author(s):  
Pooja Ghosh ◽  
Priyadarsi De
Keyword(s):  
Neurodegenerative Diseases ◽  
Synthetic Polymers ◽  
Amyloid Protein ◽  
Recent Advances ◽  
Protein Fibrillation

From nucleobase to DNA templates for precision supramolecular assemblies and synthetic polymers

2016 ◽  
Vol 7 (25) ◽  
pp. 4137-4150 ◽  
Author(s):  
Mathieu Surin
Keyword(s):  
Synthetic Polymers ◽  
Supramolecular Assemblies ◽  
Supramolecular Polymers ◽  
Dna Templates ◽  
Recent Advances

In this minireview, we report on the recent advances of utilization of nucleobases and DNA as templates to achieve well-defined supramolecular polymers, synthetic polymers, and sequence-controlled polymers.

Adenovirus in the brain: recent advances of gene therapy for neurodegenerative diseases

1998 ◽  
Vol 55 (4) ◽  
pp. 333-341 ◽  
Author(s):  
M. Barkats ◽  
A. Bilang-Bleuel ◽  
M.H. Buc-Caron ◽  
M.N. Castel-Barthe ◽  
O. Corti ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Neurodegenerative Diseases ◽  
Recent Advances ◽  
The Brain

scholarly journals Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Gels ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 46
Author(s):  
Sihang Liu ◽  
Jingyi Tang ◽  
Fangqin Ji ◽  
Weifeng Lin ◽  
Shengfu Chen
Keyword(s):  
Immune System ◽  
Polyethylene Glycol ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Synthetic Polymers ◽  
Human Environment ◽  
The Past ◽  
Recent Advances ◽  
Nonspecific Protein Adsorption ◽  
Anionic Groups

Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.

Recent advances in LC-MS/MS methods to determine endocannabinoids in biological samples: Application in neurodegenerative diseases

2018 ◽  
Vol 1044 ◽  
pp. 12-28 ◽  
Author(s):  
Camila Marchioni ◽  
Israel Donizeti de Souza ◽  
Vinicius Ricardo Acquaro ◽  
José Alexandre de Souza Crippa ◽  
Vitor Tumas ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Biological Samples ◽  
Recent Advances

scholarly journals An Overview of Crucial Dietary Substances and Their Modes of Action for Prevention of Neurodegenerative Diseases

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 576 ◽  
Author(s):  
Lea Pogačnik ◽  
Ajda Ota ◽  
Nataša Poklar Ulrih
Keyword(s):  
Oxidative Stress ◽  
Neurodegenerative Diseases ◽  
Mechanisms Of Action ◽  
Biological Mechanisms ◽  
Health Concerns ◽  
The Central Nervous System ◽  
Protein Fibrillation ◽  
Endogenous Substances ◽  
Therapeutic Considerations ◽  
Lateral Sclerosis

Neurodegenerative diseases, namely Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis are becoming one of the main health concerns due to the increasing aging of the world’s population. These diseases often share the same biological mechanisms, including neuroinflammation, oxidative stress, and/or protein fibrillation. Recently, there have been many studies published pointing out the possibilities to reduce and postpone the clinical manifestation of these deadly diseases through lifelong consumption of some crucial dietary substances, among which phytochemicals (e.g., polyphenols) and endogenous substances (e.g., acetyl-L-carnitine, coenzyme Q10, n-3 poysaturated fatty acids) showed the most promising results. Another important issue that has been pointed out recently is the availability of these substances to the central nervous system, where they have to be present in high enough concentrations in order to exhibit their neuroprotective properties. As so, such the aim of this review is to summarize the recent findings regarding neuroprotective substances, their mechanisms of action, as well as to point out therapeutic considerations, including their bioavailability and safety for humans.

scholarly journals MECHANISMS OF COGNITIVE AND NEUROLOGICAL AGING

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S587-S587
Author(s):  
Catherine Kaczorowski
Keyword(s):  
Neurodegenerative Diseases ◽  
Neurological Function ◽  
Biological Aging ◽  
Recent Advances ◽  
Age Related

Abstract This session will focus on recent advances in understanding how biological aging impacts neurological function and risk of developing age-related neurodegenerative diseases.

scholarly journals Gold nanoparticles from magnetite for the detection of amyloid proteins in neurodegenerative diseases

2021 ◽  
Vol 3 (1) ◽  
pp. 11-20
Author(s):  
Alejandro ORTIZ ◽  
Zeyris HERRERA ◽  
Johanna MOSCOSO
Keyword(s):  
Gold Nanoparticles ◽  
Neurodegenerative Diseases ◽  
Early Stage ◽  
Amyloid Plaques ◽  
Selective Detection ◽  
Amyloid Protein ◽  
Amyloid Peptides ◽  
Detection Systems ◽  
Magnetic Center ◽  
Specific Ligand

Introduction. Currently, neurodegenerative diseases (ND) are the fourth leading cause of death worldwide that pose a great challenge in the development of tools for early diagnosis. Thus, advances in science seek sensitive and selective detection systems and this manuscript will highlight the importance of nanotechnology. Material and methods. A literature review was conducted on the representative findings of NPs technologies in neurodegenerative diseases. Articles written in both English and Spanish were included. References between 2015-2021 were also taken into account. Results. One of the most representative techniques, AuNP was specifically implemented, together with a magnetic center composed of magnetite, which has as a specific ligand with a C-terminal cysteine domain present in the B-amyloid protein, which adhere directly to the surface of the NPs, characterizing the anomalous protein. Subsequently, by means of nanosensors capable of detecting and measuring different concentrations, these pathologies are identified at an early stage. Conclusions. Today, along with the advent of biotechnology, it has been possible to design techniques with NPs that allow the identification of specific mutations and provide diagnosis in individuals. In the investigative models of AuNP, it is possible to infer that the capabilities that make them representative focus on their magnetism and biofunctionality, by specifically binding to amyloid peptides and other ligands present in the protein, which are the major components of amyloid plaques used in these studies.

Sign in / Sign up

Export Citation Format

Share Document