Self-Assembled Plasmid Delivery System for PPM1D Knockout to Reverse Tumor Malignancy

2020 ◽  
Vol 3 (11) ◽  
pp. 7831-7839
Author(s):  
Xiao-He Ren ◽  
Xiao-Yan He ◽  
Bo-Ya Liu ◽  
Chang Xu ◽  
Si-Xue Cheng
Keyword(s):  
Delivery System ◽  
Self Assembled ◽  
Plasmid Delivery

scholarly journals Self-Assembled Tetrahedral Framework Nucleic Acid Mediated Tumor-Associated Macrophages Reprogramming and Enhancing Cancer Immunotherapy

2021 ◽  
Author(s):  
husun qian ◽  
Yixin Fu ◽  
Minkang Guo ◽  
Wu Yang ◽  
Dian Zhang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Delivery System ◽  
Signal Pathways ◽  
Tumor Associated Macrophages ◽  
Tetrahedral Framework ◽  
Immunomodulatory Agents ◽  
Cpg Odns ◽  
Targeting Delivery ◽  
M1 Phenotype ◽  
Self Assembled

Abstract There is increasing interest in depleting or repolarizing tumor-associated macrophages (TAMs) to generate a pro-inflammatory effect. However, TAMs usually display an immunosuppressive M2-like phenotype in tumor microenvironment. Apparently, developing a macrophage targeting delivery system with immunomodulatory agents is urgent. In the study, an efficient siRNAs and CpG ODNs delivery system (CpG-siRNA-tFNA) was prepared with nucleic acid stepwise self-assembled. The tFNA composed of CpG ODNs and siRNAs showed a higher stability and an enhanced cellular uptake efficiency. Moreover, the CpG-siRNA-tFNA effectively reprogrammed TAMs toward M1 phenotype polarization with increased pro-inflammatory cytokines secretion and NF-κB signal pathways activation, which triggers dramatical antitumor immune responses. Hence, we have developed an efficient and reliable TAM-targeted therapeutic with immunomodulatory agents for for clinical applications.

Self-Assembled saRNA Delivery System Based on Rolling Circle Transcription for Aptamer-Targeting Cancer Therapy

2019 ◽  
Vol 2 (11) ◽  
pp. 4737-4746
Author(s):  
Tengfei Wang ◽  
Shanni Hong ◽  
Yu Luo ◽  
Haiyin Lv ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Delivery System ◽  
Rolling Circle ◽  
Self Assembled

scholarly journals A self-assembled RNA-triple helix hydrogel drug delivery system targeting triple-negative breast cancer

2020 ◽  
Vol 8 (16) ◽  
pp. 3527-3533 ◽  
Author(s):  
Lairong Ding ◽  
Junwei Li ◽  
Changrong Wu ◽  
Feng Yan ◽  
Xuemei Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Triple Negative Breast Cancer ◽  
Triple Helix ◽  
Triple Negative ◽  
Breast Cancers ◽  
Self Assembled ◽  
Rna Triple Helix

A novel RNA-triple-helix hydrogel for treatment of triple negative breast cancers (TNBCs) by incorporating RNA-triple-helix and siRNA duplexes of CXCR4 into the same RNA nanoparticles was developed, without the synthetic polycationic reagents.

scholarly journals Self-assembled pH-responsive supramolecular hydrogel for hydrophobic drug delivery

RSC Advances ◽  
2018 ◽  
Vol 8 (55) ◽  
pp. 31581-31587 ◽  
Author(s):  
Lin Wang ◽  
Xuefeng Shi ◽  
Jian Zhang ◽  
Yuejun Zhu ◽  
Jinben Wang
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hydrophobic Drug ◽  
Ph Responsive ◽  
Supramolecular Hydrogel ◽  
Self Assembled

Supramolecular hydrogel, AGC16/NTS, was used to encapsulate hydrophobic drug curcumin (Cur), constructing a pH-responsive drug delivery system; the uptake of released Cur by cancer cells also occurred.

Highly uniform self-assembled microspheres from single macromolecule self-recognition for enhanced cancer immunotherapy

2020 ◽  
Vol 56 (64) ◽  
pp. 9190-9193
Author(s):  
Xin Shen ◽  
Zhenxia Zhou ◽  
Dongmei Qi ◽  
Yanchao Li ◽  
Zhiying Zeng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Immunotherapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Local Drug Delivery ◽  
Self Recognition ◽  
Self Assembled ◽  
Local Drug Delivery System ◽  
Highly Uniform ◽  
Single Macromolecule

Self-assembled highly uniform microspheres has been developed as a local drug delivery system for effective synergistic immunotherapy.

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