Exploring the Biocompatibility of Near-IR CuInSexS2–x/ZnS Quantum Dots for Deep-Tissue Bioimaging

2020 ◽  
Vol 3 (12) ◽  
pp. 8567-8574
Author(s):  
Jessica Z. Kubicek-Sutherland ◽  
Nikolay S. Makarov ◽  
Zachary R. Stromberg ◽  
Kiersten D. Lenz ◽  
Chloe Castañeda ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Deep Tissue ◽  
Near Ir

scholarly journals Bright quantum dots emitting at ∼1,600 nm in the NIR-IIb window for deep tissue fluorescence imaging

2018 ◽  
Vol 115 (26) ◽  
pp. 6590-6595 ◽  
Author(s):  
Mingxi Zhang ◽  
Jingying Yue ◽  
Ran Cui ◽  
Zhuoran Ma ◽  
Hao Wan ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Fluorescence Imaging ◽  
Lead Sulfide ◽  
Critical Role ◽  
Deep Tissue ◽  
Blood Flows ◽  
Near Ir ◽  
Tissue Fluorescence

With suppressed photon scattering and diminished autofluorescence, in vivo fluorescence imaging in the 1,500- to 1,700-nm range of the near-IR (NIR) spectrum (NIR-IIb window) can afford high clarity and deep tissue penetration. However, there has been a lack of NIR-IIb fluorescent probes with sufficient brightness and aqueous stability. Here, we present a bright fluorescent probe emitting at ∼1,600 nm based on core/shell lead sulfide/cadmium sulfide (CdS) quantum dots (CSQDs) synthesized in organic phase. The CdS shell plays a critical role of protecting the lead sulfide (PbS) core from oxidation and retaining its bright fluorescence through the process of amphiphilic polymer coating and transferring to water needed for imparting aqueous stability and compatibility. The resulting CSQDs with a branched PEG outer layer exhibited a long blood circulation half-life of 7 hours and enabled through-skin, real-time imaging of blood flows in mouse vasculatures at an unprecedented 60 frames per second (fps) speed by detecting ∼1,600-nm fluorescence under 808-nm excitation. It also allowed through-skin in vivo confocal 3D imaging of tumor vasculatures in mice with an imaging depth of ∼1.2 mm. The PEG-CSQDs accumulated in tumor effectively through the enhanced permeation and retention effect, affording a high tumor-to-normal tissue ratio up to ∼32 owing to the bright ∼1,600-nm emission and nearly zero autofluorescence background resulting from a large ∼800-nm Stoke’s shift. The aqueous-compatible CSQDs are excreted through the biliary pathway without causing obvious toxicity effects, suggesting a useful class of ∼1,600-nm emitting probes for biomedical research.

Optimizing the Synthesis of Red- to Near-IR-Emitting CdS-Capped CdTexSe1-xAlloyed Quantum Dots for Biomedical Imaging

2006 ◽  
Vol 18 (20) ◽  
pp. 4845-4854 ◽  
Author(s):  
Wen Jiang ◽  
Anupam Singhal ◽  
Jianing Zheng ◽  
Chen Wang ◽  
Warren C. W. Chan
Keyword(s):  
Quantum Dots ◽  
Biomedical Imaging ◽  
Near Ir

The one-pot synthesis of core/shell/shell CdTe/CdSe/ZnSe quantum dots in aqueous media for in vivo deep tissue imaging

2011 ◽  
Vol 21 (9) ◽  
pp. 2877 ◽  
Author(s):  
Shohei Taniguchi ◽  
Mark Green ◽  
Sarwat B. Rizvi ◽  
Alexander Seifalian
Keyword(s):  
Quantum Dots ◽  
Aqueous Media ◽  
Tissue Imaging ◽  
Core Shell ◽  
Deep Tissue ◽  
One Pot ◽  
One Pot Synthesis ◽  
Deep Tissue Imaging ◽  
The One

scholarly journals Near-IR-induced dissociation of thermally-sensitive star polymers

2017 ◽  
Vol 8 (3) ◽  
pp. 1815-1821 ◽  
Author(s):  
Yuqiong Dai ◽  
Hao Sun ◽  
Sunirmal Pal ◽  
Yunlu Zhang ◽  
Sangwoo Park ◽  
...  
Keyword(s):  
Near Infrared ◽  
Star Polymers ◽  
Tissue Penetration ◽  
Triggered Release ◽  
Deep Tissue ◽  
Responsive Systems ◽  
Nir Light ◽  
Near Ir ◽  
Triggering Events ◽  
Spatiotemporal Control

Responsive systems sensitive to near-infrared (NIR) light are promising for triggered release due to efficient deep tissue penetration of NIR irradiation relative to higher energy sources (e.g., UV), allowing for spatiotemporal control over triggering events with minimal potential for tissue damage.

Efficient two-photon luminescence for cellular imaging using biocompatible nitrogen-doped graphene quantum dots conjugated with polymers

Nanoscale ◽  
2018 ◽  
Vol 10 (1) ◽  
pp. 109-117 ◽  
Author(s):  
Ping-Ching Wu ◽  
Jiu-Yao Wang ◽  
Wen-Lung Wang ◽  
Chia-Yuan Chang ◽  
Chia-Hung Huang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Contrast Agent ◽  
Graphene Quantum Dots ◽  
Cellular Imaging ◽  
Deep Tissue ◽  
Nitrogen Doped ◽  
Two Photon ◽  
Nitrogen Doped Graphene ◽  
Doped Graphene

N-doped GQDs conjugated with polymers demonstrate impressive two-photon properties and stability, and can be used as a contrast agent in deep tissue bioimaging.

Measurement of the luminescence decay times of PbS quantum dots in the near-IR spectral range

2012 ◽  
Vol 112 (6) ◽  
pp. 868-873 ◽  
Author(s):  
P. S. Parfenov ◽  
A. P. Litvin ◽  
A. V. Baranov ◽  
E. V. Ushakova ◽  
A. V. Fedorov ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Spectral Range ◽  
Luminescence Decay ◽  
Near Ir ◽  
Decay Times ◽  
Pbs Quantum Dots

scholarly journals Extremely High Brightness from Polymer-Encapsulated Quantum Dots for Two-photon Cellular and Deep-tissue Imaging

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Yanyan Fan ◽  
Helin Liu ◽  
Rongcheng Han ◽  
Lu Huang ◽  
Hao Shi ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Tissue Imaging ◽  
Deep Tissue ◽  
High Brightness ◽  
Two Photon ◽  
Deep Tissue Imaging

Functional Characteristics of QD-InAs/GaAs Heterostructures with Potential Barriers AlGaAs and GaAs

2018 ◽  
Vol 284 ◽  
pp. 182-187
Author(s):  
E.E. Blokhin ◽  
D.A. Arustamyan ◽  
L.M. Goncharova
Keyword(s):  
Quantum Dots ◽  
High Speed ◽  
Ion Beam ◽  
Inas Quantum Dots ◽  
Potential Barriers ◽  
Near Ir ◽  
Current Voltage ◽  
Ir Photodetectors ◽  
Current Voltage Characteristics ◽  
Beam Deposition

In this paper we present the results of investigation of heterostructures with an array of InAs quantum dots grown on GaAs substrates with GaAs and AlGaAs front barriers for high-speed near-IR photodetectors. The thickness of the barrier layers did not exceed 30 nm. It is shown that the ion-beam deposition method makes it possible to grow quantum dots with lateral dimensions up to 30 nm and 15 nm height. The spectral dependences of the external quantum efficiency and dark current-voltage characteristics are investigated.

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