Gelatin Methacrylate as an Enzyme-Controlled Release Vehicle of Hyaluronic Acid for the Treatment of Recurrent Corneal Erosion

2020 ◽  
Vol 3 (9) ◽  
pp. 6214-6223
Author(s):  
John W. Tse ◽  
Muhammad Rizwan ◽  
Jonathan Rasmussen ◽  
Lyndon Jones ◽  
Evelyn K. F. Yim
Keyword(s):  
Hyaluronic Acid ◽  
Controlled Release ◽  
Corneal Erosion ◽  
Recurrent Corneal Erosion

scholarly journals Recurrent corneal erosion syndrome

1999 ◽  
Vol 83 (11) ◽  
pp. 1312-1312
Author(s):  
G J MENON; ◽  
P. HEYWORTH ◽  
J. DART
Keyword(s):  
Corneal Erosion ◽  
Recurrent Corneal Erosion

Clinical Presentation and Causes of Recurrent Corneal Erosion Syndrome

Cornea ◽  
2014 ◽  
Vol 33 (6) ◽  
pp. 571-575 ◽  
Author(s):  
Elío Diez-Feijóo ◽  
Arturo E. Grau ◽  
Eugenia I. Abusleme ◽  
Juan A. Durán
Keyword(s):  
Clinical Presentation ◽  
Corneal Erosion ◽  
Recurrent Corneal Erosion

scholarly journals Experimental Study of Diamond Burr Polishing Methods of Bowman’s Membrane

2018 ◽  
Vol 15 (2) ◽  
pp. 176-181 ◽  
Author(s):  
S. V. Trufanov ◽  
A. A. Fedorov ◽  
V. R. Mamikonyan ◽  
L. Yu. Tekeeva ◽  
S. A. Malozhen ◽  
...  
Keyword(s):  
Corneal Epithelium ◽  
Surgical Intervention ◽  
Rotation Frequency ◽  
Basal Membrane ◽  
Corneal Erosion ◽  
Recurrent Corneal Erosion ◽  
Diamond Burr ◽  
Clinical Conditions ◽  
Histopathological Investigation ◽  
Selection Of

Purpose: to develop the optimal (safe and effective) method of diamond burr polishing of Bowman’s membrane (DBPBM) for the possible use it in the treatment of the recurrent corneal erosion syndrome (RCES) in the experiment.Material and methods. DBPBM in different modifications of the  method and the mechanical deepithelization were performed in  experiment on 19 human cadaver eyes. We use system Ophtho-Burr  for DBPBM that includes a tip and ophthalmic burrs with diameter  1mm, 2.5 mm, 5 mm, varying the speed of rotation of burr. For 3  eyes — polishing with the application of burr with a diameter of 5  mm, the rotation frequency of 4000 rpm using 2 passes over the  surface of the cornea. For 3 eyes — burr with a diameter of 2.5 mm,  rotation frequency of 4000 rpm in 2 perpendicular passes. For 3 eyes — diameter burr 1 mm at speed of 8000 rpm in 2 perpendicular  passes. For 3 eyes — diameter burr 1 mm at speed 4000 rpm with 4  passes along the surface of the cornea. For 4 eyes — diameter was 1 mm at speed of 4000 rpm in 2 perpendicular passes. For 3 the eyes  was conducted mechanical deepithelization. Subsequent histopathological investigation of the cornea was  performed by method of semi-thin section, with polychrome staining.Results. The obtained results of histological studies of DBPBM in  different versions on cadaver cornea is allowed to choose the optimal variant of surgical intervention for use in clinical conditions. It  consisted in a selection of burr with a diameter of 1 mm, the rotation frequency of the 4000 rpm and 2 perpendicular passes with a  moderate compression of the cornea. The abovementioned technique of intervention allows removing completely the corneal epithelium  with a basal membrane and save uniform in thickness, fully  deepitelizationed Bowman’s membrane.Conclusion.Careful and accurate removal of dysplastic corneal epithelium in cases of the recurrent corneal erosion syndrome using  proposed method in clinical conditions should contribute to the  creation optimal environments for adequate reepithelization with  steady epithelial-stromal adhesion. The remaining nearly intact  Bowman’s membrane after procedure can prevent some postoperative complications such as haze and induced refractive disorders.

scholarly journals Role of artificial tears with and without hyaluronic acid in controlling ocular discomfort following PRK: a randomized clinical trial

2021 ◽  
Vol 14 (8) ◽  
pp. 1225-1230
Author(s):  
Mehrdad Mohammadpour ◽  
◽  
Delaram Shakoor ◽  
Keyword(s):  
Clinical Trial ◽  
Hyaluronic Acid ◽  
Randomized Clinical Trial ◽  
Visual Analogue Score ◽  
Control Group ◽  
Artificial Tears ◽  
Blurred Vision ◽  
Corneal Erosion ◽  
Ocular Discomfort ◽  
Haze Formation

AIM: To compare outcomes of applying preservative free artificial tears (PFAT) with and without hyaluronic acid (HA) in early postoperative course following photorefractive keratectomy (PRK). METHODS: In this triple-blinded randomized clinical trial, PRK procedure was performed on both eyes of 230 patients. Following PRK, patients were divided into three groups: the HA+ group, 44 patients PFAT containing HA; the HA- group, 71 patients PFAT without HA were administered 5 times per day (every 4h); the third group, 115 patients received no PFAT before lens removal. On the 1st and 4th postoperative day, Visual Analogue Score (VAS) was utilized to evaluate patient’s level of pain. Participants were asked to complete a questionnaire about the severity of eye discomfort ranked from 0 to 10 (0=no complaint; 10=most severe complaint experienced). RESULTS: In eyes receiving PFAT with or without HA (Drop group), mean scores for epiphora, foreign body sensation, and blurred vision on the 1st postoperative day were statistically lower (P<0.05). Filamentous keratitis (FK) was detected in 11 (4.7%) eyes, and recurrent corneal erosion (RCE) was observed in 5 (2.1%) eyes. In the control group, FK was noted in 16 (6.9%) eyes while 13 (5.6%) eyes had RCE and 5 (2.1%) eyes had corneal haze. The rate of complications was statistically lower in Drop group (P=0.009). However, the aforementioned scores were not statically different between HA+ and HA- group one and two (P=0.29). CONCLUSION: Following PRK, applying PFAT with and without HA yields faster visual recovery, decreases postoperative ocular discomfort and haze formation; however there is no additive effect for HA.

The diagnosis and management of recurrent corneal erosion syndrome

2015 ◽  
Vol 10 (5) ◽  
pp. 453-463
Author(s):  
Prafulla K Maharana ◽  
Aditi Dubey ◽  
Vishal Jhanji ◽  
Rasik B Vajpayee
Keyword(s):  
Diagnosis And Management ◽  
Corneal Erosion ◽  
Recurrent Corneal Erosion
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