Near-Infrared Polymer Dots in the Portal-Hepatic Circulation Achieve Localization of Hepatic Carcinoma In Vivo

2020 ◽  
Vol 3 (9) ◽  
pp. 6177-6186
Author(s):  
Di Zhou ◽  
Yi Dian Yang ◽  
Long Yang Jin ◽  
Yong Yang ◽  
Shou Hua Wang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Hepatic Circulation ◽  
Hepatic Carcinoma ◽  
Polymer Dots

Cyanine-Based Polymer Dots with Long-Wavelength Excitation and Near-Infrared Fluorescence beyond 900 nm for In Vivo Biological Imaging

2020 ◽  
Vol 3 (6) ◽  
pp. 3846-3858 ◽  
Author(s):  
Ming-Ho Liu ◽  
Tzu-Chun Chen ◽  
Juvinch R. Vicente ◽  
Chun-Nien Yao ◽  
Yu-Chi Yang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Biological Imaging ◽  
Near Infrared Fluorescence ◽  
Long Wavelength ◽  
Polymer Dots

scholarly journals Preparation of Near-Infrared/Photoacoustic Dual-Mode Imaging and Photothermal/Chemo Synergistic Theranostic Nanoparticles and Their Imaging and Treating of Hepatic Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Yun Zhou ◽  
Bixia Lin ◽  
Kai Li ◽  
Yufeng Zhao ◽  
Zhuo Sun ◽  
...  
Keyword(s):  
Colloidal Stability ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Low Cost ◽  
Functional Materials ◽  
Hepatic Carcinoma ◽  
Dual Mode ◽  
Photothermal Conversion ◽  
Theranostic Nanoparticles

At present, the clinical diagnosis of and treatment methods for hepatic carcinoma still fail to fully meet the needs of patients. The integrated theranostic system, in which functional materials are used to load different active molecules, created a new developmental direction for the combination treatment of hepatic carcinoma, realizing the synchronization of diagnosis and treatment. In this study, polydopamine (PDA), which has the functions of self-assembly, encapsulation, photothermal conversion, and photoacoustic interaction, was used as the carrier material. The IR780, a near-infrared fluorescence imaging (NIFI), photoacoustic imaging (PAI), and photothermal therapy (PTT) agent, and paclitaxel (PTX), a broad-spectrum chemotherapy drug, were selected to build the NIF/PA dual-mode imaging and PTT/chemo synergistic theranostic nanoparticles (DIST NPs). The DIST NPs have a 103.4 ± 13.3 nm particle size, a weak negative charge on the surface, good colloidal stability, slow and controlled drug release, and high photothermal conversion ability. The experiments results showed that the DIST NPs have a long circulation in vivo, high bioavailability, high biocompatibility, and low effective dose. DIST NPs showed an excellent NIFI/PAI dual-mode imaging and significant synergistic antitumor effect in hepatic carcinoma models. DIST NPs met the initial design requirements. A set of fast and low-cost preparation methods was established. This study provides an experimental basis for the development of new clinical theranostic methods for hepatic carcinoma.

Near-Infrared (NIR)-Absorbing Conjugated Polymer Dots as Highly Effective Photothermal Materials for In Vivo Cancer Therapy

2016 ◽  
Vol 28 (23) ◽  
pp. 8669-8675 ◽  
Author(s):  
Shengliang Li ◽  
Xiaoyu Wang ◽  
Rong Hu ◽  
Hui Chen ◽  
Meng Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Conjugated Polymer ◽  
Near Infrared ◽  
Polymer Dots ◽  
Highly Effective

Long-Term-Stable Near-Infrared Polymer Dots with Ultrasmall Size and Narrow-Band Emission for Imaging Tumor Vasculature in Vivo

2015 ◽  
Vol 26 (5) ◽  
pp. 817-821 ◽  
Author(s):  
Liqin Xiong ◽  
Fengwen Cao ◽  
Xinmin Cao ◽  
Yixiao Guo ◽  
Yimin Zhang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Narrow Band ◽  
Tumor Vasculature ◽  
Band Emission ◽  
Polymer Dots

Simultaneous near-infrared and green fluorescence from single conjugated polymer dots with aggregation-induced emission fluorogen for cell imaging

2018 ◽  
Vol 6 (47) ◽  
pp. 7871-7876 ◽  
Author(s):  
Sitong Chen ◽  
Shuang Cui ◽  
Rongxin Du ◽  
Ming Liu ◽  
Wei-Kai Tsai ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Near Infrared ◽  
Cell Imaging ◽  
Green Fluorescence ◽  
Aggregation Induced Emission ◽  
Polymer Dots

Highly fluorescent conjugated polymer dots with aggregation-induced emission fluorogen were applied in in vitro and in vivo cell imaging.

Quinoxaline-Based Polymer Dots with Ultrabright Red to Near-Infrared Fluorescence for In Vivo Biological Imaging

2015 ◽  
Vol 137 (32) ◽  
pp. 10420-10429 ◽  
Author(s):  
Hong-Yi Liu ◽  
Pei-Jing Wu ◽  
Shih-Yu Kuo ◽  
Chuan-Pin Chen ◽  
En-Hao Chang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Biological Imaging ◽  
Near Infrared Fluorescence ◽  
Polymer Dots

In vivo dynamic cell tracking with long-wavelength excitable and near-infrared fluorescent polymer dots

Biomaterials ◽  
2020 ◽  
Vol 254 ◽  
pp. 120139 ◽  
Author(s):  
Ye Yuan ◽  
Zhe Zhang ◽  
Weiying Hou ◽  
Weiping Qin ◽  
Zihui Meng ◽  
...  
Keyword(s):  
Cell Tracking ◽  
Near Infrared ◽  
Long Wavelength ◽  
Polymer Dots ◽  
Dynamic Cell ◽  
Fluorescent Polymer
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