pH-Sensitive Near-IR Emitting Dinuclear Ruthenium Complex for Recognition, Two-Photon Luminescent Imaging, and Subcellular Localization of Cancer Cells

2020 ◽  
Vol 3 (8) ◽  
pp. 5420-5427
Author(s):  
Hui-Yu Liu ◽  
Si-Qi Zhang ◽  
Meng-Chao Cui ◽  
Li-Hua Gao ◽  
Hua Zhao ◽  
...  
Keyword(s):  
Subcellular Localization ◽  
Cancer Cells ◽  
Ruthenium Complex ◽  
Ph Sensitive ◽  
Two Photon ◽  
Near Ir ◽  
Dinuclear Ruthenium

scholarly journals Metal Complexes for Two-Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-Photon Photosensitization of Cancer Cells under Near-IR Light

2016 ◽  
Vol 23 (2) ◽  
pp. 234-238 ◽  
Author(s):  
Luke K. McKenzie ◽  
Igor V. Sazanovich ◽  
Elizabeth Baggaley ◽  
Mickaële Bonneau ◽  
Véronique Guerchais ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Complexes ◽  
Cancer Cells ◽  
Iridium Complex ◽  
Two Photon ◽  
Near Ir ◽  
Ir Light

scholarly journals Highly sensitive detection of cancer cells using femtosecond dual-wavelength near-IR two-photon imaging

2012 ◽  
Vol 3 (7) ◽  
pp. 1534 ◽  
Author(s):  
Jean R. Starkey ◽  
Nikolay S. Makarov ◽  
Mikhail Drobizhev ◽  
Aleksander Rebane
Keyword(s):  
Cancer Cells ◽  
Dual Wavelength ◽  
Sensitive Detection ◽  
Two Photon ◽  
Near Ir ◽  
Highly Sensitive ◽  
Photon Imaging ◽  
Two Photon Imaging ◽  
Highly Sensitive Detection

Ruthenium complex-modified carbon nanodots for lysosome-targeted one- and two-photon imaging and photodynamic therapy

Nanoscale ◽  
2017 ◽  
Vol 9 (47) ◽  
pp. 18966-18976 ◽  
Author(s):  
Dong-Yang Zhang ◽  
Yue Zheng ◽  
Hang Zhang ◽  
Liang He ◽  
Cai-Ping Tan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Ruthenium Complex ◽  
Carbon Nanodots ◽  
Two Photon ◽  
Photon Imaging ◽  
Two Photon Imaging

Nanohybrids can in most cases kill cancer cells more efficiently as compared with free photosensitizers.

An estrogen receptor targeted ruthenium complex as a two-photon photodynamic therapy agent for breast cancer cells

2018 ◽  
Vol 54 (51) ◽  
pp. 7038-7041 ◽  
Author(s):  
Xueze Zhao ◽  
Mingle Li ◽  
Wen Sun ◽  
Jiangli Fan ◽  
Jianjun Du ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Ruthenium Complex ◽  
Two Photon ◽  
Polypyridyl Complex

In this study, we reported a tamoxifen modified Ru(ii) polypyridyl complex (Ru-tmxf) as an estrogen receptor (ER) targeted photosensitizer.

scholarly journals Subcellular Localization of Sigma-2 Receptors in Breast Cancer Cells Using Two-Photon and Confocal Microscopy

2007 ◽  
Vol 67 (14) ◽  
pp. 6708-6716 ◽  
Author(s):  
Chenbo Zeng ◽  
Suwanna Vangveravong ◽  
Jinbin Xu ◽  
Katherine C. Chang ◽  
Richard S. Hotchkiss ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Confocal Microscopy ◽  
Subcellular Localization ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Two Photon

scholarly journals Frontispiece: Metal Complexes for Two-Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-Photon Photosensitization of Cancer Cells under Near-IR Light

2017 ◽  
Vol 23 (2) ◽  
Author(s):  
Luke K. McKenzie ◽  
Igor V. Sazanovich ◽  
Elizabeth Baggaley ◽  
Mickaële Bonneau ◽  
Véronique Guerchais ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Complexes ◽  
Cancer Cells ◽  
Iridium Complex ◽  
Two Photon ◽  
Near Ir ◽  
Ir Light

scholarly journals Two-photon, visible light water splitting at a molecular ruthenium complex

2021 ◽  
Author(s):  
Jacob Schneidewind ◽  
Miguel A. Argüello Cordero ◽  
Henrik Junge ◽  
Stefan Lochbrunner ◽  
Matthias Beller
Keyword(s):  
Visible Light ◽  
Water Splitting ◽  
Ruthenium Complex ◽  
Visible Region ◽  
Light Water ◽  
Two Photon

A new mechanism for light-driven water splitting is described, which decreases the reaction's complexity and offers a new way to extend the range of usable wavelengths far into the visible region.

scholarly journals Ruthenium-based PACT agents based on bisquinoline chelates: synthesis, photochemistry, and cytotoxicity

2021 ◽  
Author(s):  
Anja Busemann ◽  
Ingrid Flaspohler ◽  
Xue-Quan Zhou ◽  
Claudia Schmidt ◽  
Sina K. Goetzfried ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Ruthenium Complex ◽  
Human Cancer ◽  
Light Irradiation ◽  
Quantum Yields ◽  
Light Activation ◽  
Human Cancer Cells

AbstractThe known ruthenium complex [Ru(tpy)(bpy)(Hmte)](PF6)2 ([1](PF6)2, where tpy = 2,2’:6’,2″-terpyridine, bpy = 2,2’-bipyridine, Hmte = 2-(methylthio)ethanol) is photosubstitutionally active but non-toxic to cancer cells even upon light irradiation. In this work, the two analogs complexes [Ru(tpy)(NN)(Hmte)](PF6)2, where NN = 3,3'-biisoquinoline (i-biq, [2](PF6)2) and di(isoquinolin-3-yl)amine (i-Hdiqa, [3](PF6)2), were synthesized and their photochemistry and phototoxicity evaluated to assess their suitability as photoactivated chemotherapy (PACT) agents. The increase of the aromatic surface of [2](PF6)2 and [3](PF6)2, compared to [1](PF6)2, leads to higher lipophilicity and higher cellular uptake for the former complexes. Such improved uptake is directly correlated to the cytotoxicity of these compounds in the dark: while [2](PF6)2 and [3](PF6)2 showed low EC50 values in human cancer cells, [1](PF6)2 is not cytotoxic due to poor cellular uptake. While stable in the dark, all complexes substituted the protecting thioether ligand upon light irradiation (520 nm), with the highest photosubstitution quantum yield found for [3](PF6)2 (Φ[3] = 0.070). Compounds [2](PF6)2 and [3](PF6)2 were found both more cytotoxic after light activation than in the dark, with a photo index of 4. Considering the very low singlet oxygen quantum yields of these compounds, and the lack of cytotoxicity of the photoreleased Hmte thioether ligand, it can be concluded that the toxicity observed after light activation is due to the photoreleased aqua complexes [Ru(tpy)(NN)(OH2)]2+, and thus that [2](PF6)2 and [3](PF6)2 are promising PACT candidates. Graphic abstract

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