Metal–Organic Framework Polymer Coating Inhibits Staphylococcus aureus Attachment on Medical Circulation Tubing under Static and Dynamic Flow Conditions

2020 ◽  
Vol 3 (6) ◽  
pp. 3535-3543 ◽  
Author(s):  
Yanyi Zang ◽  
Teryn R. Roberts ◽  
Andriy I. Batchinsky ◽  
Melissa M. Reynolds
Keyword(s):  
Staphylococcus Aureus ◽  
Polymer Coating ◽  
Metal Organic Framework ◽  
Flow Conditions ◽  
Dynamic Flow ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Metal-organic framework functionalized polymer coating for fiber optical methane sensors

2020 ◽  
Vol 324 ◽  
pp. 128627 ◽  
Author(s):  
Rongtao Cao ◽  
Hangjun Ding ◽  
Ki-Joong Kim ◽  
Zhaoqiang Peng ◽  
Jingyu Wu ◽  
...  
Keyword(s):  
Polymer Coating ◽  
Metal Organic Framework ◽  
Fiber Optical ◽  
Metal Organic ◽  
Organic Framework

Highly sensitive optical biosensing of Staphylococcus aureus with an antibody/metal–organic framework bioconjugate

2019 ◽  
Vol 11 (7) ◽  
pp. 917-923 ◽  
Author(s):  
Neha Bhardwaj ◽  
Sanjeev K. Bhardwaj ◽  
Deepanshu Bhatt ◽  
Satish K. Tuteja ◽  
Ki-Hyun Kim ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Metal Organic Framework ◽  
Optical Biosensing ◽  
Amine Functionalized ◽  
Highly Sensitive ◽  
Metal Organic ◽  
Organic Framework

In this research, a new luminescent bioprobe was developed for the detection of S. aureus based on bio-conjugation of an amine functionalized metal–organic framework (NH2-MIL-53(Fe)) with an anti-S. aureus antibody (Ab).

scholarly journals Robust Copper Metal–Organic Framework-Embedded Polysiloxanes for Biomedical Applications: Its Antibacterial Effects on MRSA and In Vitro Cytotoxicity

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 719
Author(s):  
Kihak Gwon ◽  
Youngmee Kim ◽  
Hyunjun Cho ◽  
Seonhwa Lee ◽  
So-Hyeon Yang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Metal Organic Framework ◽  
In Vitro Cytotoxicity ◽  
Disease Treatment ◽  
Metal Organic ◽  
Bactericidal Activities ◽  
Low Cytotoxicity ◽  
Phosphate Buffered Saline ◽  
Organic Framework

Polysiloxanes (PSs) have been widely utilized in the industry as lubricants, varnishes, paints, release agents, adhesives, and insulators. In addition, their applications have been expanded to include the development of new biomedical materials. To modify PS for application in therapeutic purposes, a flexible antibacterial Cu-MOF (metal–organic framework) consisting of glutarate and 1,2-bis(4-pyridyl)ethane ligands was embedded in PS via a hydrosilylation reaction of vinyl-terminated and H-terminated PSs at 25 °C. The bactericidal activities of the resulting Cu-MOF-embedded PS (PS@Cu-MOF) and the control polymer (PS) were tested against Escherichia coli, Staphylococcus aureus, and methicillin-resistant Staphylococcus aureus. PS@Cu-MOF exhibited more than 80% bactericidal activity toward the tested bacteria at a concentration of 100 μg⋅mL−1 and exhibited a negligible cytotoxicity toward mouse embryonic fibroblasts at the same concentration. Release tests of the Cu(II) ion showed PS@Cu-MOF to be particularly stable in a phosphate-buffered saline solution. Furthermore, its physical and thermal properties, including the phase transition, rheological measurements, swelling ratio, and thermogravimetric profile loss, were similar to those of the control polymer. Moreover, the low cytotoxicity and bactericidal activities of PS@Cu-MOF render it a promising candidate for use in medicinal applications, such as in implants, skin-disease treatment, wound healing, and drug delivery.

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