Push–Pull Stilbene: Visible Light Activated Photoremovable Protecting Group for Alcohols and Carboxylic Acids with Fluorescence Reporting Employed for Drug Delivery

2019 ◽  
Vol 21 (9) ◽  
pp. 2968-2972 ◽  
Author(s):  
Amrita Paul ◽  
Angana Biswas ◽  
Sreyashi Sinha ◽  
Sk. Sheriff Shah ◽  
Manoranjan Bera ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Visible Light ◽  
Carboxylic Acids ◽  
Protecting Group

A Protecting Group for Carboxylic Acids That Can Be Photolyzed by Visible Light†

Biochemistry ◽  
2005 ◽  
Vol 44 (19) ◽  
pp. 7107-7114 ◽  
Author(s):  
Vishakha R. Shembekar ◽  
Yongli Chen ◽  
Barry K. Carpenter ◽  
George P. Hess
Keyword(s):  
Visible Light ◽  
Carboxylic Acids ◽  
Protecting Group

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

On-DNA Derivatization of Quinoxalin-2-ones by Visible-Light-Triggered Alkylation with Carboxylic Acids

2021 ◽  
Author(s):  
Yue Zhang ◽  
Huadong Luo ◽  
Huiyong Ma ◽  
Jinqiao Wan ◽  
Yue Ji ◽  
...  
Keyword(s):  
Visible Light ◽  
Carboxylic Acids

Visible-light-mediated catalytic decarboxylative alkylation of 2-pyridone derivatives via a C3-selective C–H functionalization

2021 ◽  
Author(s):  
Worawat Niwetmarin ◽  
Rungroj Saruengkhanphasit ◽  
Chatchakorn Eurtivong ◽  
Somsak Ruchirawat
Keyword(s):  
Visible Light ◽  
Carboxylic Acids ◽  
Reductive Cleavage ◽  
Alkyl Radicals

A direct C–H functionalization approach to access C3-alkylated 2-pyridone derivatives is reported. This study utilizes N-hydroxyphthalimide (NHPI) esters of various carboxylic acids as sources for alkyl radicals by reductive cleavage...

scholarly journals Decarboxylative Cyanation of Aliphatic Carboxylic Acids via Visible-Light Flavin Photocatalysis

2019 ◽  
Vol 21 (5) ◽  
pp. 1368-1373 ◽  
Author(s):  
Nieves P. Ramirez ◽  
Burkhard König ◽  
Jose C. Gonzalez-Gomez
Keyword(s):  
Visible Light ◽  
Carboxylic Acids ◽  
Aliphatic Carboxylic Acids

scholarly journals Preparation of Succinoglycan Hydrogel Coordinated With Fe3+ Ions for Controlled Drug Delivery

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 977 ◽  
Author(s):  
Yiluo Hu ◽  
Daham Jeong ◽  
Yohan Kim ◽  
Seonmok Kim ◽  
Seunho Jung
Keyword(s):  
Drug Delivery ◽  
Visible Light ◽  
Sinorhizobium Meliloti ◽  
Environmental Changes ◽  
Controlled Drug Delivery ◽  
Attenuated Total Reflection ◽  
Extracellular Polysaccharides ◽  
Rheological Analysis ◽  
Wide Range ◽  
Potential Applications

Hydrogel materials with a gel-sol conversion due to external environmental changes have potential applications in a wide range of fields, including controlled drug delivery. Succinoglycans are anionic extracellular polysaccharides produced by various bacteria, including Sinorhizobium species, which have diverse applications. In this study, the rheological analysis confirmed that succinoglycan produced by Sinorhizobium meliloti Rm 1021 binds weakly to various metal ions, including Fe2+ cations, to maintain a sol form, and binds strongly to Fe3+ cations to maintain a gel form. The Fe3+-coordinated succinoglycan (Fe3+-SG) hydrogel was analyzed by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, circular dichroism (CD), and field-emission scanning electron microscopy (FE-SEM). Our results revealed that the Fe3+ cations that coordinated with succinoglycan were converted to Fe2+ by a reducing agent and visible light, promoting a gel-sol conversion. The Fe3+-SG hydrogel was then successfully used for controlled drug delivery based on gel-sol conversion in the presence of reducing agents and visible light. As succinoglycan is nontoxic, it is a potential material for controlled drug delivery.

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