Catalytic Asymmetric [3 + 2] Cyclization Reactions of 3-Isothiocyanato Oxindoles and Alkynyl Ketones Via an in Situ Generated Magnesium Catalyst

2015 ◽  
Vol 17 (17) ◽  
pp. 4260-4263 ◽  
Author(s):  
Linqing Wang ◽  
Dongxu Yang ◽  
Dan Li ◽  
Xihong Liu ◽  
Qian Zhao ◽  
...  
Keyword(s):  
Cyclization Reactions ◽  
Catalytic Asymmetric

ChemInform Abstract: Catalytic Asymmetric [3 + 2] Cyclization Reactions of 3-Isothiocyanato Oxindoles and Alkynyl Ketones via an in situ Generated Magnesium Catalyst.

ChemInform ◽  
2016 ◽  
Vol 47 (4) ◽  
pp. no-no
Author(s):  
Linqing Wang ◽  
Dongxu Yang ◽  
Dan Li ◽  
Xihong Liu ◽  
Qian Zhao ◽  
...  
Keyword(s):  
Cyclization Reactions ◽  
Catalytic Asymmetric

In situ cyclization reactions during the preparation of high-performance methacrylic acid/acrylonitrile/acrylamide ternary copolymer foam

2007 ◽  
Vol 106 (3) ◽  
pp. 1462-1469 ◽  
Author(s):  
Tie-Min Liu ◽  
Guang-Cheng Zhang ◽  
Guo-Zheng Liang ◽  
Ting Chen ◽  
Cui Zhang
Keyword(s):  
Methacrylic Acid ◽  
High Performance ◽  
Cyclization Reactions ◽  
Ternary Copolymer

Catalytic Asymmetric Construction of Pyrroloindolines via an in Situ Generated Magnesium Catalyst

2014 ◽  
Vol 17 (2) ◽  
pp. 176-179 ◽  
Author(s):  
Linqing Wang ◽  
Dongxu Yang ◽  
Fengxia Han ◽  
Dan Li ◽  
Depeng Zhao ◽  
...  
Keyword(s):  
Catalytic Asymmetric

scholarly journals Synthesis of indazolo[5,4-b][1,6]naphthyridine and indazolo[6,7-b][1,6]naphthyridine derivatives

2019 ◽  
Vol 25 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Dong-Mei Chen ◽  
Jia-Yan Liu ◽  
Ming Wei ◽  
Bing-Wei Wang ◽  
Ruo-Han Chu ◽  
...  
Keyword(s):  
Aromatic Aldehydes ◽  
Cyclization Reactions ◽  
Simple Method

AbstractA simple method for the synthesis of the title compounds by an efficient in-situ reduction and cyclization reactions of aromatic aldehydes, tert-butyl 2,4-dioxopiperidine-1-carboxylate and 5-nitro-1H-indazole or 6-nitro-1H-indazole was developed.

Intramolecular Michael Addition of N- and O-Centred Nucleophiles to Tethered Acrylates. The Role of Double-Bond Geometry in Controlling the Diastereo- selectivity of Cyclizations Leading to 2,6-Disubstituted Tetrahydropyrans and Piperidines.

1998 ◽  
Vol 51 (1) ◽  
pp. 9 ◽  
Author(s):  
Martin G. Banwell ◽  
Brett D. Bissett ◽  
Chinh T. Bui ◽  
Ha T. T. Pham ◽  
Gregory W. Simpson
Keyword(s):  
Double Bond ◽  
Total Synthesis ◽  
Michael Addition ◽  
Reductive Amination ◽  
Major Product ◽  
Enantioselective Synthesis ◽  
Cyclization Reactions ◽  
Glandular Secretion

The oxyanion derived from hydroxyacrylate E-(5) undergoes smooth intramolecular Michael addition to give the trans-2,6-disubstituted tetrahydropyran (7) as the major product of reaction. In contrast, the oxyanion obtained from isomer Z-(5) cyclizes to give the cis-2,6-disubstituted tetrahydropyran (6) as the major product. Such chemistry has been extended to the enantioselective synthesis of (+)-(6) the acquisition of which constitutes a formal total synthesis of acid (+)-(2), a constituent of the glandular secretion from the civet cat (Viverra civetta). Reductive amination of keto acrylate (12) affords an intermediate amine which cyclizes, in situ, to give the cis-2,6-disubstituted piperidine (26). Analogous treatment of compound (13) delivers the isomeric trans-2,6-disubstituted piperidine (27) as the exclusive product of reaction. Transition state structures have been proposed to account for the diastereoselectivities observed in all of the cyclization reactions.

ChemInform Abstract: Catalytic Asymmetric Addition of Meldrum′s Acid, Malononitrile, and 1,3-Dicarbonyls to ortho-Quinone Methides Generated in situ under Basic Conditions.

ChemInform ◽  
2015 ◽  
Vol 46 (35) ◽  
pp. no-no
Author(s):  
Lorenzo Caruana ◽  
Martina Mondatori ◽  
Vasco Corti ◽  
Sara Morales ◽  
Andrea Mazzanti ◽  
...  
Keyword(s):  
Quinone Methides ◽  
Asymmetric Addition ◽  
Catalytic Asymmetric
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