Harpertrioate A, an A,B,D-seco-Limonoid with Promising Biological Activity against Alzheimer’s Disease from Twigs of Harrisonia perforata (Blanco) Merr.

2020 ◽  
Author(s):  
Xiao-Han Tang ◽  
Rong-Can Luo ◽  
Mao-Sen Ye ◽  
Hong-Yu Tang ◽  
Yuan-Liang Ma ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biological Activity

scholarly journals Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer’s disease

2020 ◽  
Vol 100 ◽  
pp. 103928
Author(s):  
Rozálie Peřinová ◽  
Negar Maafi ◽  
Jan Korábečný ◽  
Eliška Kohelová ◽  
Angela De Simone ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biological Activity ◽  
In Silico ◽  
Aromatic Esters

scholarly journals Recent Progress on Biological Activity of Amaryllidaceae and Further Isoquinoline Alkaloids in Connection with Alzheimer’s Disease

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5240
Author(s):  
Lucie Cahlíková ◽  
Rudolf Vrabec ◽  
Filip Pidaný ◽  
Rozálie Peřinová ◽  
Negar Maafi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biological Activity ◽  
Life Expectancy ◽  
Neurodegenerative Disease ◽  
Elderly People ◽  
Recent Progress ◽  
Isoquinoline Alkaloids ◽  
Amaryllidaceae Alkaloids ◽  
Age Related

Alzheimer’s disease (AD) is a progressive age-related neurodegenerative disease recognized as the most common form of dementia among elderly people. Due to the fact that the exact pathogenesis of AD still remains to be fully elucidated, the treatment is only symptomatic and available drugs are not able to modify AD progression. Considering the increase in life expectancy worldwide, AD rates are predicted to increase enormously, and thus the search for new AD drugs is urgently needed. Due to their complex nitrogen-containing structures, alkaloids are considered to be promising candidates for use in the treatment of AD. Since the introduction of galanthamine as an antidementia drug in 2001, Amaryllidaceae alkaloids (AAs) and further isoquinoline alkaloids (IAs) have been one of the most studied groups of alkaloids. In the last few years, several compounds of new structure types have been isolated and evaluated for their biological activity connected with AD. The present review aims to comprehensively summarize recent progress on AAs and IAs since 2010 up to June 2021 as potential drugs for the treatment of AD.

Synthesis, molecular docking, and biological activity of 2-vinyl chromones: Toward selective butyrylcholinesterase inhibitors for potential Alzheimer's disease therapeutics

2018 ◽  
Vol 26 (16) ◽  
pp. 4716-4725 ◽  
Author(s):  
Galina F. Makhaeva ◽  
Natalia P. Boltneva ◽  
Sofya V. Lushchekina ◽  
Elena V. Rudakova ◽  
Olga G. Serebryakova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biological Activity ◽  
Molecular Docking

scholarly journals In vitro Biological Activity of Salvia leriifolia Benth Essential Oil Relevant to the Treatment of Alzheimer's Disease

2009 ◽  
Vol 58 (8) ◽  
pp. 443-446 ◽  
Author(s):  
Monica Rosa Loizzo ◽  
Federica Menichini ◽  
Rosa Tundis ◽  
Marco Bonesi ◽  
Filomena Conforti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biological Activity ◽  
Essential Oil

3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity

2006 ◽  
Vol 16 (14) ◽  
pp. 3839-3842 ◽  
Author(s):  
Richard A. Jelley ◽  
Jason Elliott ◽  
Karl R. Gibson ◽  
Timothy Harrison ◽  
Dirk Beher ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Biological Activity ◽  
Conformational Analysis
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