Chiral Phosphoric Acid Catalyzed Enantioselective [4 + 2] Cycloaddition Reaction of α-Fluorostyrenes with Imines

2020 ◽  
Vol 22 (22) ◽  
pp. 8957-8961
Author(s):  
Jun Kikuchi ◽  
Haiting Ye ◽  
Masahiro Terada
Keyword(s):  
Phosphoric Acid ◽  
Cycloaddition Reaction ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed

ChemInform Abstract: Chiral Phosphoric Acid Catalyzed Enantioselective 1,3-Dipolar Cycloaddition Reaction of Azlactones.

ChemInform ◽  
2016 ◽  
Vol 47 (21) ◽  
Author(s):  
Zhenhua Zhang ◽  
Wangsheng Sun ◽  
Gongming Zhu ◽  
Junxian Yang ◽  
Ming Zhang ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed

Chiral phosphoric acid catalyzed enantioselective 1,3-dipolar cycloaddition reaction of azlactones

2016 ◽  
Vol 52 (7) ◽  
pp. 1377-1380 ◽  
Author(s):  
Zhenhua Zhang ◽  
Wangsheng Sun ◽  
Gongming Zhu ◽  
Junxian Yang ◽  
Ming Zhang ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed

The first chiral phosphoric acid catalyzed highly diastereo- and enantioselective 1,3-dipolar cycloaddition reaction of azlactones and methyleneindolinones was disclosed to yield 3,3′-pyrrolidonyl spirooxindole scaffolds.

Chiral phosphoric acid catalyzed enantioselective annulation of acyclic enecarbamates to in situ-generated ortho-quinone methides

2017 ◽  
Vol 15 (35) ◽  
pp. 7272-7276 ◽  
Author(s):  
Chandan Gharui ◽  
Shreya Singh ◽  
Subhas Chandra Pan
Keyword(s):  
Phosphoric Acid ◽  
Cycloaddition Reaction ◽  
Quinone Methides ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed ◽  
Phosphoric Acids

The first organocatalytic asymmetric [4 + 2]-cycloaddition reaction between acyclic enecarbamates with in situ generated ortho-quinone methides has been developed using chiral phosphoric acids as catalysts.

Chiral Phosphoric Acid Catalyzed Stereoselective Spiroketalizations

Synlett ◽  
2013 ◽  
Vol 24 (06) ◽  
pp. 661-665 ◽  
Author(s):  
Pavel Nagorny ◽  
Zhankui Sun ◽  
Grace Winschel
Keyword(s):  
Phosphoric Acid ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed

scholarly journals Catalytic Enantioselective Synthesis of 4-Amino-1,2,3,4-tetrahydropyridine Derivatives from Intramolecular Nucleophilic Addition Reaction of Tertiary Enamides

Synlett ◽  
2018 ◽  
Vol 30 (04) ◽  
pp. 483-487 ◽  
Author(s):  
Shuo Tong ◽  
Mei-Xiang Wang
Keyword(s):  
Phosphoric Acid ◽  
Asymmetric Catalysis ◽  
Nucleophilic Addition ◽  
Addition Reaction ◽  
Enantioselective Synthesis ◽  
Chiral Phosphoric Acid ◽  
Substrate Engineering ◽  
Nucleophilic Addition Reaction ◽  
Engineering Strategy ◽  
Acid Catalyzed

A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed. We have also demonstrated a substrate engineering strategy to significantly improve the enantioselectivity of asymmetric catalysis

scholarly journals Identifying the true origins of selectivity in chiral phosphoric acid catalyzed N-acyl-azetidine desymmetrizations

2021 ◽  
Author(s):  
Pier Alexandre Champagne
Keyword(s):  
Phosphoric Acid ◽  
Chiral Phosphoric Acid ◽  
Transition Structures ◽  
Acid Catalyzed

The origins of selectivity in azetidine desymmetrizations have been determined computationally. Comparison of structures with model and full catalysts provided key details missed by typical analyses of the stereodetermining transition structures.

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