Enantioselective Synthesis of a 2,3-Benzodiazepine Intermediate of BET Inhibitor BAY 1238097 via Catalytic Asymmetric Hydrogenation

2020 ◽  
Vol 24 (2) ◽  
pp. 255-260 ◽  
Author(s):  
Gerard K. M. Verzijl ◽  
Jorma Hassfeld ◽  
André H. M. de Vries ◽  
Laurent Lefort
Keyword(s):  
Asymmetric Hydrogenation ◽  
Enantioselective Synthesis ◽  
Bet Inhibitor ◽  
Catalytic Asymmetric ◽  
Catalytic Asymmetric Hydrogenation

Highly Enantioselective Synthesis of Chiral 3-Substituted Indolines by Catalytic Asymmetric Hydrogenation of Indoles

2004 ◽  
Vol 6 (13) ◽  
pp. 2213-2215 ◽  
Author(s):  
Ryoichi Kuwano ◽  
Kohei Kaneda ◽  
Takashi Ito ◽  
Koji Sato ◽  
Takashi Kurokawa ◽  
...  
Keyword(s):  
Asymmetric Hydrogenation ◽  
Enantioselective Synthesis ◽  
Catalytic Asymmetric ◽  
Catalytic Asymmetric Hydrogenation

scholarly journals Highly Enantioselective Synthesis of Chiral 3-Substituted Indolines by Catalytic Asymmetric Hydrogenation of Indoles.

ChemInform ◽  
2004 ◽  
Vol 35 (42) ◽  
Author(s):  
Ryoichi Kuwano ◽  
Kohei Kaneda ◽  
Takashi Ito ◽  
Koji Sato ◽  
Takashi Kurokawa ◽  
...  
Keyword(s):  
Asymmetric Hydrogenation ◽  
Enantioselective Synthesis ◽  
Catalytic Asymmetric ◽  
Catalytic Asymmetric Hydrogenation

scholarly journals Divergent enantioselective synthesis of hapalindole-type alkaloids using catalytic asymmetric hydrogenation of a ketone to construct the chiral core structure

2016 ◽  
Vol 7 (7) ◽  
pp. 4725-4729 ◽  
Author(s):  
Yang Liu ◽  
Li-Jie Cheng ◽  
Hai-Tao Yue ◽  
Wen Che ◽  
Jian-Hua Xie ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
Asymmetric Hydrogenation ◽  
Core Structure ◽  
Enantioselective Synthesis ◽  
Catalytic Asymmetric ◽  
Catalytic Asymmetric Hydrogenation

A divergent enantioselective approach to hapalindole-type alkaloids featuring a ruthenium-catalyzed asymmetric hydrogenation and a switchable sequence of methylation and acetylation/aldol reaction is described.

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