Investigation into an Unexpected Impurity: A Practical Approach to Process Development for the Addition of Grignard Reagents to Aldehydes Using Continuous Flow Synthesis

2020 ◽  
Vol 24 (3) ◽  
pp. 405-414 ◽  
Author(s):  
Masahiro Hosoya ◽  
Shogo Nishijima ◽  
Noriyuki Kurose
Keyword(s):  
Continuous Flow ◽  
Process Development ◽  
Practical Approach ◽  
Grignard Reagents ◽  
Flow Synthesis

Continuous Flow Synthesis of Ketones from Carbon Dioxide and Organolithium or Grignard Reagents

2014 ◽  
Vol 126 (32) ◽  
pp. 8556-8560 ◽  
Author(s):  
Jie Wu ◽  
Xiaoqing Yang ◽  
Zhi He ◽  
Xianwen Mao ◽  
T. Alan Hatton ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Continuous Flow ◽  
Grignard Reagents ◽  
Flow Synthesis

scholarly journals Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran

RSC Advances ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 2199-2204 ◽  
Author(s):  
Chuan-Tao Zhang ◽  
Rui Zhu ◽  
Zheng Wang ◽  
Bing Ma ◽  
Adrian Zajac ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Parallel Synthesis ◽  
Grignard Reagents ◽  
Acyl Chlorides ◽  
Flow Synthesis ◽  
Flow Method ◽  
Mild Conditions ◽  
Continuous Flow Method

Continuous flow method for parallel synthesis of diaryl ketones using commercially available reagents.

Continuous Flow Synthesis of Ketones from Carbon Dioxide and Organolithium or Grignard Reagents

2014 ◽  
Vol 53 (32) ◽  
pp. 8416-8420 ◽  
Author(s):  
Jie Wu ◽  
Xiaoqing Yang ◽  
Zhi He ◽  
Xianwen Mao ◽  
T. Alan Hatton ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Continuous Flow ◽  
Grignard Reagents ◽  
Flow Synthesis

Continuous flow synthesis of the lamivudine precursor L-Menthyl Glyoxylate

2021 ◽  
Author(s):  
Lais S. D. Azevedo ◽  
Anderson R. Aguillon ◽  
Marcelo T. Lima ◽  
Raquel A. C. Leão ◽  
Rodrigo O. M. A. de Souza
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis

Continuous Flow Synthesis of Persistent Luminescent Chromium-Doped Zinc Gallate Nanoparticles

2021 ◽  
pp. 7067-7075
Author(s):  
Xiaojun Wei ◽  
Stephen V. Kershaw ◽  
Xiaodan Huang ◽  
Mingxia Jiao ◽  
Chau Chun Beh ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis ◽  
Zinc Gallate

scholarly journals Continuous flow synthesis of azoxybenzenes by reductive dimerization of nitrosobenzenes with gel‐bound catalysts

2021 ◽  
Author(s):  
Carsten J. Schmiegel ◽  
Patrik Berg ◽  
Franziska Obst ◽  
Roland Schoch ◽  
Dietmar Appelhans ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis ◽  
Reductive Dimerization

scholarly journals Continuous Flow Synthesis of Metal–NHC Complexes**

2021 ◽  
Vol 27 (18) ◽  
pp. 5653-5657 ◽  
Author(s):  
Andreas Simoens ◽  
Thomas Scattolin ◽  
Thibault Cauwenbergh ◽  
Gianmarco Pisanò ◽  
Catherine S. J. Cazin ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis
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