Experimental Estimation of Primary and Secondary Nucleation Kinetics of Antisolvent Crystallization As Measured by Induction Time

2019 ◽  
Vol 23 (12) ◽  
pp. 2724-2732 ◽  
Author(s):  
Takanori Kodera ◽  
Masanori Kobari ◽  
Izumi Hirasawa
Keyword(s):  
Induction Time ◽  
Nucleation Kinetics ◽  
Secondary Nucleation ◽  
Experimental Estimation ◽  
Antisolvent Crystallization ◽  
Kinetics Of

scholarly journals Secondary Nucleation Kinetics of AIBN Crystallisation in Methanol: Online Imaging-Based Measurement and Modelling

Crystals ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 506
Author(s):  
Yang Li ◽  
Yang Zhang ◽  
Xue Zhong Wang
Keyword(s):  
Nucleation Rate ◽  
Induction Time ◽  
Nucleation Process ◽  
Stirrer Speed ◽  
Seed Number ◽  
Nucleation Kinetics ◽  
Secondary Nucleation ◽  
On Line ◽  
Small Change ◽  
Crystal Seed

The secondary nucleation process of 2,2-azobisisobutyronitrile (AIBN) seeded crystallisation in methanol in a stirred tank reactor was studied at varying initial supersaturation levels, temperatures, crystal seed numbers, and stirrer speeds. The average secondary nucleation rate, induction time, and agglomeration ratio were measured using on-line microscopic imaging. The initial supersaturation level, temperature, and stirrer speed were found to be positively correlated with the secondary nucleation rate. A small change in the crystal seed number, i.e., 1-20, did not substantially affect the secondary nucleation rate throughout the secondary nucleation process. An increase in the initial supersaturation level and crystal seed number decreased the induction time, and an increase in the strength of agitation promoted the initiation of secondary nucleation at a stirring rate greater than 250 revolutions per minute (rpm). Temperature exerted a complex effect on the induction time. Regarding the agglomeration ratio, the initial supersaturation level positively correlated with the agglomeration ratio, while the stirrer speed negatively correlated with this parameter. Finally, based on the measured data, the average secondary nucleation rate, induction time, and final crystal suspension density were correlated. This study provides guidance for the control of supersaturation, induction time, stirring, and other factors in the crystal seed addition process in AIBN crystallisation.

Nucleation kinetics of paracetamol–ethanol solutions from induction time experiments using Lasentec FBRM®

2011 ◽  
Vol 321 (1) ◽  
pp. 91-99 ◽  
Author(s):  
Niall A. Mitchell ◽  
Patrick J. Frawley ◽  
Clifford T. Ó’Ciardhá
Keyword(s):  
Induction Time ◽  
Nucleation Kinetics ◽  
Kinetics Of

An Explanation of the Removal of Metastability in Some Hydroacid Salts by Water Adsorption

2001 ◽  
Vol 56 (12) ◽  
pp. 869-872
Author(s):  
B. Baranowski ◽  
A. Lundén
Keyword(s):  
Phase Transition ◽  
Surface Layer ◽  
Water Activity ◽  
Induction Time ◽  
Lattice Spacing ◽  
Water Adsorption ◽  
Zeroth Order ◽  
Exponential Functions ◽  
Kinetics Of ◽  
Volume Decrease

Abstract The metastability of some phases of CsHSO4 and RbH2PO4 is due to the volume decrease at an endothermic phase transition which "locks in" the metastability in question. Water adsorption, which removes these metastabilities, probably exerts a "wedge-like" force which expands the lattice spacing in the surface layer, thus facilitating the start of the phase transition. The induction time and the zeroth order kinetics of the transition in RbH2PO4 are exponential functions of the water activity applied.

Observation of the nucleation kinetics of Si quantum dots on SiO2 by EFTEM

2018 ◽  
pp. 119-122
Author(s):  
G Nicotra ◽  
S Lombardo ◽  
R Puglisi ◽  
C Spinella ◽  
G Ammendola ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Nucleation Kinetics ◽  
Kinetics Of ◽  
Si Quantum Dots

The nucleation kinetics of ammonium metavanadate precipitated by ammonium chloride

2016 ◽  
Vol 441 ◽  
pp. 117-123 ◽  
Author(s):  
Guangchao Du ◽  
Zhaohui Sun ◽  
Yong Xian ◽  
Han Jing ◽  
Haijun Chen ◽  
...  
Keyword(s):  
Ammonium Chloride ◽  
Ammonium Metavanadate ◽  
Nucleation Kinetics ◽  
Kinetics Of

Nucleation rates and the kinetics of particle growth II. The birth and death process

1964 ◽  
Vol 277 (1369) ◽  
pp. 167-182 ◽  
Keyword(s):  
Steady State ◽  
Homogeneous Nucleation ◽  
Time Lag ◽  
Particle Growth ◽  
Statistical Problem ◽  
Death Process ◽  
Birth And Death Process ◽  
Growth Mechanisms ◽  
Nucleation Kinetics ◽  
Kinetics Of

The model considered in part I is generalized to include growth mechanisms in which the chemical reaction which proceeds at the particle-atm osphere interface is reversible, so that molecules may evaporate from a particle as well as condense upon it. The Becker-Döring-Zeldovich-Frenkel theory of homogeneous nucleation kinetics is then reviewed in the light of the known statistical problem of the birth -and -death process, and an improved approximation is introduced which significantly alters the calculated results. Both steady-state nucleation kinetics and the time lag problem are discussed.

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