scholarly journals Asymmetric Synthesis of Letermovir Using a Novel Phase-Transfer-Catalyzed Aza-Michael Reaction

2016 ◽  
Vol 20 (6) ◽  
pp. 1097-1103 ◽  
Author(s):  
Guy R. Humphrey ◽  
Stephen M. Dalby ◽  
Teresa Andreani ◽  
Bangping Xiang ◽  
Michael R. Luzung ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Michael Reaction ◽  
Phase Transfer

scholarly journals Diastereoselective auxiliary- and catalyst-controlled intramolecular aza-Michael reaction for the elaboration of enantioenriched 3-substituted isoindolinones. Application to the synthesis of a new pazinaclone analogue

2018 ◽  
Vol 14 ◽  
pp. 593-602 ◽  
Author(s):  
Romain Sallio ◽  
Stéphane Lebrun ◽  
Frédéric Capet ◽  
Francine Agbossou-Niedercorn ◽  
Christophe Michon ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Michael Reaction ◽  
Phase Transfer ◽  
Benzodiazepine Receptor ◽  
Optically Active ◽  
Chiral Auxiliary ◽  
Phase Transfer Catalyst ◽  
Receptor Agonists ◽  
Michael Acceptor

A new asymmetric organocatalyzed intramolecular aza-Michael reaction by means of both a chiral auxiliary and a catalyst for stereocontrol is reported for the synthesis of optically active isoindolinones. A selected cinchoninium salt was used as phase-transfer catalyst in combination with a chiral nucleophile, a Michael acceptor and a base to provide 3-substituted isoindolinones in good yields and diastereomeric excesses. This methodology was applied to the asymmetric synthesis of a new pazinaclone analogue which is of interest in the field of benzodiazepine-receptor agonists.

ChemInform Abstract: Base-Dependent Stereodivergent Intramolecular Aza-Michael Reaction: Asymmetric Synthesis of 1,3-Disubstituted Isoindolines.

ChemInform ◽  
2014 ◽  
Vol 45 (3) ◽  
pp. no-no
Author(s):  
Santos Fustero ◽  
Lidia Herrera ◽  
Ruben Lazaro ◽  
Elsa Rodriguez ◽  
Miguel A. Maestro ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Michael Reaction

ChemInform Abstract: Enantioselective Phase-Transfer-Catalyzed Intramolecular Aza-Michael Reaction: Effective Route to Pyrazino-Indole Compounds.

ChemInform ◽  
2008 ◽  
Vol 39 (34) ◽  
Author(s):  
Marco Bandini ◽  
Astrid Eichholzer ◽  
Michele Tragni ◽  
Achille Umani-Ronchi
Keyword(s):  
Michael Reaction ◽  
Phase Transfer ◽  
Indole Compounds

ChemInform Abstract: Chiral Salen-Metal Complexes as Novel Catalysts for the Asymmetric Synthesis of α-Amino Acids under Phase Transfer Catalysis Conditions.

ChemInform ◽  
2010 ◽  
Vol 32 (30) ◽  
pp. no-no
Author(s):  
Yuri N. Belokon ◽  
Michael North ◽  
Tatiana D. Churkina ◽  
Nikolai S. Ikonnikov ◽  
Victor I. Maleev
Keyword(s):  
Amino Acids ◽  
Metal Complexes ◽  
Asymmetric Synthesis ◽  
Phase Transfer Catalysis ◽  
Phase Transfer
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