scholarly journals Potential of Homogeneous Pd Catalyst Separation by Ceramic Membranes. Application to Downstream and Continuous Flow Processes

2016 ◽  
Vol 20 (5) ◽  
pp. 911-920 ◽  
Author(s):  
Dominic Ormerod ◽  
Nicolas Lefevre ◽  
Matthieu Dorbec ◽  
Inge Eyskens ◽  
Pieter Vloemans ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Ceramic Membranes ◽  
Pd Catalyst ◽  
Flow Processes ◽  
Catalyst Separation

scholarly journals Continuous-Flow Processes for the Production of Floxacin Intermediates: Efficient C–C Bond Formation through a Rapid and Strong Activation of Carboxylic Acids

2020 ◽  
Vol 02 (03) ◽  
pp. e128-e132
Author(s):  
Shao-Zheng Guo ◽  
Zhi-Qun Yu ◽  
Wei-Ke Su
Keyword(s):  
Reaction Time ◽  
Continuous Flow ◽  
Flow System ◽  
Bond Formation ◽  
Product Yield ◽  
Raw Material ◽  
Material Consumption ◽  
Tank Reactor ◽  
Mild Conditions ◽  
Flow Processes

AbstractThe development of highly efficient C–C bond formation methods for the synthesis of ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-(dimethylamino)acrylate 1 in continuous flow processes has been described, which is based on the concept of rapid and efficient activation of carboxylic acid. 2,4-Dichloro-5-fluorobenzoic acid is rapidly converted into highly reactive 2,4-dichloro-5-fluorobenzoyl chloride by treating with inexpensive and less-toxic solid bis(trichloromethyl)carbonate. And then it rapidly reacts with ethyl 3-(dimethylamino)acrylate to afford the desired 1. This process can be performed under mild conditions. Compared with the traditional tank reactor process, less raw material consumption, higher product yield, less reaction time, higher operation safety ensured by more the environmentally friendly procedure, and process continuity are achieved in the continuous-flow system.

Enhanced quality control in continuous flow processes

1990 ◽  
Vol 19 (1-4) ◽  
pp. 258-262 ◽  
Author(s):  
John R. English ◽  
Tep Sastri
Keyword(s):  
Quality Control ◽  
Continuous Flow ◽  
Flow Processes

Continuous flow processes for the S-alkynylation of cysteine-containing peptides and thioglycoside under catalyst-free, oxidant-free and mild conditions

2021 ◽  
Author(s):  
Long-Zhou Qin ◽  
Xin Yuan ◽  
Jie Liu ◽  
Meng-yu Wu ◽  
Qi Sun ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Mild Conditions ◽  
Catalyst Free ◽  
Flow Processes ◽  
Novel Method

Herein, we develop a novel method for the selective alkynylation of cysteine-containing peptides and 1-thioglycoside residues by the use of continuous flow. This method was characterised by the mild conditions...

scholarly journals Imine Reductase Based All-Enzyme Hydrogel with Intrinsic Cofactor Regeneration for Flow Biocatalysis

Micromachines ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 783 ◽  
Author(s):  
Patrick Bitterwolf ◽  
Felix Ott ◽  
Kersten S. Rabe ◽  
Christof M. Niemeyer
Keyword(s):  
Continuous Flow ◽  
Viscoelastic Properties ◽  
Mesh Size ◽  
Binding Kinetics ◽  
Flow Mode ◽  
Efficient Manner ◽  
Flow Rates ◽  
Covalent Crosslinking ◽  
Flow Processes ◽  
Space Time Yield

All-enzyme hydrogels are biocatalytic materials, with which various enzymes can be immobilized in microreactors in a simple, mild, and efficient manner to be used for continuous flow processes. Here we present the construction and application of a cofactor regenerating hydrogel based on the imine reductase GF3546 from Streptomyces sp. combined with the cofactor regenerating glucose-1-dehydrogenase from Bacillus subtilis. The resulting hydrogel materials were characterized in terms of binding kinetics and viscoelastic properties. The materials were formed by rapid covalent crosslinking in less than 5 min, and they showed a typical mesh size of 67 ± 2 nm. The gels were applied for continuous flow biocatalysis. In a microfluidic reactor setup, the hydrogels showed excellent conversions of imines to amines for up to 40 h in continuous flow mode. Variation of flow rates led to a process where the gels showed a maximum space-time-yield of 150 g·(L·day)−1 at 100 μL/min.

scholarly journals Catalytic Hydrodechlorination of Chlorophenols in a Continuous Flow Pd/CNT-Ni Foam Micro Reactor Using Formic Acid as a Hydrogen Source

Catalysts ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 77 ◽  
Author(s):  
Jun Xiong ◽  
Ying Ma
Keyword(s):  
Catalytic Activity ◽  
Formic Acid ◽  
Continuous Flow ◽  
Catalyst Surface ◽  
Reactor System ◽  
Packed Bed Reactor ◽  
Pd Catalyst ◽  
Ni Foam ◽  
Catalytic Hydrodechlorination ◽  
Micro Reactor

Catalytic hydrodechlorination (HDC) has been considered as a promising method for the treatment of wastewater containing chlorinated organic pollutants. A continuous flow Pd/carbon nanotube (CNT)-Ni foam micro reactor system was first developed for the rapid and highly efficient HDC with formic acid (FA) as a hydrogen source. This micro reactor system, exhibiting a higher catalytic activity of HDC than the conventional packed bed reactor, reduced the residence time and formic acid consumption significantly. The desired outcomes (dichlorination >99.9%, 4-chlorophenol outlet concentration <0.1 mg/L) can be obtained under a very low FA/substrate molar ratio (5:1) and short reaction cycle (3 min). Field emission scanning electron microcopy (FESEM) and deactivation experiment results indicated that the accumulation of phenol (the main product during the HDC of chlorophenols) on the Pd catalyst surface can be the main factor for the long-term deactivation of the Pd/CNT-Ni foam micro reactor. The catalytic activity deactivation of the micro reactor could be almost completely regenerated by the efficient removal of the absorbed phenol from the Pd catalyst surface.

scholarly journals Synthesis of layered double hydroxides through continuous flow processes: A review

2019 ◽  
Vol 369 ◽  
pp. 302-332 ◽  
Author(s):  
Didier Tichit ◽  
Géraldine Layrac ◽  
Corine Gérardin
Keyword(s):  
Layered Double Hydroxides ◽  
Continuous Flow ◽  
Flow Processes ◽  
Double Hydroxides

Quality monitoring of continuous flow processes

1991 ◽  
Vol 20 (2) ◽  
pp. 251-260 ◽  
Author(s):  
John R. English ◽  
Murali Krishnamurthi ◽  
Tep Sastri
Keyword(s):  
Continuous Flow ◽  
Quality Monitoring ◽  
Flow Processes
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