A Design of Experiments Approach to a Robust Final Deprotection and Reactive Crystallization of IPI-926, A Novel Hedgehog Pathway Inhibitor

2015 ◽  
Vol 19 (11) ◽  
pp. 1693-1702 ◽  
Author(s):  
Theodore A. Martinot ◽  
Brian C. Austad ◽  
Alexandre Côté ◽  
Kristopher M. Depew ◽  
Daniel Genov ◽  
...  
Keyword(s):  
Design Of Experiments ◽  
Hedgehog Pathway ◽  
Reactive Crystallization ◽  
Hedgehog Pathway Inhibitor

scholarly journals Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

2009 ◽  
Vol 361 (12) ◽  
pp. 1173-1178 ◽  
Author(s):  
Charles M. Rudin ◽  
Christine L. Hann ◽  
John Laterra ◽  
Robert L. Yauch ◽  
Christopher A. Callahan ◽  
...  
Keyword(s):  
Hedgehog Pathway ◽  
Hedgehog Pathway Inhibitor

scholarly journals Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß

2019 ◽  
Vol 131 (46) ◽  
pp. 16770-16781
Author(s):  
Lea Kremer ◽  
Elisabeth Hennes ◽  
Alexandra Brause ◽  
Andrei Ursu ◽  
Lucas Robke ◽  
...  
Keyword(s):  
Hedgehog Pathway ◽  
Hedgehog Pathway Inhibitor

scholarly journals Characterization and Management of Hedgehog Pathway Inhibitor‐Related Adverse Events in Patients With Advanced Basal Cell Carcinoma

2016 ◽  
Vol 21 (10) ◽  
pp. 1218-1229 ◽  
Author(s):  
Mario E. Lacouture ◽  
Brigitte Dréno ◽  
Paolo Antonio Ascierto ◽  
Reinhard Dummer ◽  
Nicole Basset‐Seguin ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Adverse Events ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Hedgehog Pathway ◽  
Hedgehog Pathway Inhibitor ◽  
Advanced Basal Cell Carcinoma

scholarly journals A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma

Pancreas ◽  
2016 ◽  
Vol 45 (3) ◽  
pp. 370-375 ◽  
Author(s):  
Andrew H. Ko ◽  
Noelle LoConte ◽  
Margaret A. Tempero ◽  
Evan J. Walker ◽  
R. Kate Kelley ◽  
...  
Keyword(s):  
Phase I ◽  
Pancreatic Adenocarcinoma ◽  
Phase I Study ◽  
Hedgehog Pathway ◽  
Hedgehog Pathway Inhibitor ◽  
Advanced Pancreatic Adenocarcinoma
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