Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet–Spengler Condensation

2021 ◽  
Author(s):  
Jie Xu ◽  
Cheol K. Chung ◽  
Andrew McClory ◽  
Kyle A. Mack ◽  
Michael E. Dalziel ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Manufacturing Process ◽  
Efficient Manufacturing

Development of an Efficient Manufacturing Process to GSK2248761A API

2018 ◽  
Vol 22 (2) ◽  
pp. 207-211 ◽  
Author(s):  
Celine Bret ◽  
Elaine Smith ◽  
Erica Vit ◽  
Jerome F. Hayes ◽  
John D. Hayler ◽  
...  
Keyword(s):  
Manufacturing Process ◽  
Efficient Manufacturing

Development of an Efficient Manufacturing Process for E2212 toward Rapid Clinical Introduction

2019 ◽  
Vol 23 (4) ◽  
pp. 603-613
Author(s):  
Minetaka Isomura ◽  
Taiju Nakamura ◽  
Atsushi Kamada ◽  
Takeo Sasaki ◽  
Toshiyuki Uemura ◽  
...  
Keyword(s):  
Manufacturing Process ◽  
Efficient Manufacturing

Design of an Automatic Tool Changer System for Milling Machining Centers

2013 ◽  
Vol 371 ◽  
pp. 69-73 ◽  
Author(s):  
Claudiu Obreja ◽  
Gheorghe Stan ◽  
Dragoș Andrioaia ◽  
Marian Funaru
Keyword(s):  
Manufacturing Process ◽  
High Speed ◽  
Machining Process ◽  
Machining Time ◽  
Tool Magazine ◽  
Machining Center ◽  
Automatic Tool Changer ◽  
Automatic Tool ◽  
Efficient Manufacturing ◽  
Productive Time

In the field of manufacturing processes it is observed that the trend is to produce more and more fast, efficiently parts with high complexity, which involves using a high number of tools in the machining process. One of the main solutions for high speed and efficient manufacturing is based on the full automation of the entire manufacturing process. The automatic changing of the tools involved in the manufacturing process is carried out by the automatic tool changing mechanism, thus the auxiliary non-productive time consumed with the tool change is highly minimized. In this paper we present a novel automatic tool changer which is both simple and compact, and any milling machining center provided with chain or disc tool magazine can be equipped with. Also by adopting the use of this tool changing mechanism other subassemblies of the tool changing system, such as the tool transfer mechanism and the waiting position, are substituted by this changing mechanism. The auxiliary movements needed to bring the tool from the magazine into the waiting position are overlapped with the machining time, so that the total time for exchanging the tool in the spindle with the tool from the magazine is minimized.

Dielectric Coating of Cathodes for Microfabrication Using Electrochemical Method

2010 ◽  
Vol 132 (6) ◽  
Author(s):  
Anna Brusilovski
Keyword(s):  
Chemical Composition ◽  
Manufacturing Process ◽  
Electrochemical Method ◽  
Epoxy Resins ◽  
Working Environment ◽  
The Other ◽  
Diamond Like Carbon ◽  
Physical Environments ◽  
Efficient Manufacturing ◽  
Poor Adhesion

Pulse microelectrochemical machining (ECM) by bipolar current is a method allowing the manufacturing of microholes and micropatterns. In many cases, microholes with parallel walls and accurate micropatterns can only be manufactured with the application of an electrically isolating coating to the side surfaces of the cathode. The goal of this research was to find a durable coating for this process. Epoxy resins, Teflon, and diamond-like carbon are considered as dielectric cathode coatings. Different aspects of the working environment of these coatings in the pulse bipolar ECM process, such as electric field, chemical composition, and physical influences of the electrolyte, are analyzed. The main reasons for the low process durability of coatings are poor adhesion and harsh chemical and physical environments. The most promising coating for the process is diamond-like carbon, which shows significantly better performance than the other coatings. Improved adhesion of a coating to the cathode can dramatically improve its durability in the pulse bipolar ECM environment and therefore permits an efficient manufacturing process.

Cost-efficient manufacturing process of switchable glazing based on twisted nematic LC cells

2011 ◽  
Author(s):  
Eberhard Kurz ◽  
Lothar Rau ◽  
Norbert Frühauf ◽  
Walter Haase ◽  
Marijo Prskalo ◽  
...  
Keyword(s):  
Manufacturing Process ◽  
Twisted Nematic ◽  
Cost Efficient ◽  
Efficient Manufacturing

Development of an Efficient Manufacturing Process for a Key Intermediate in the Synthesis of Edoxaban

2019 ◽  
Vol 23 (4) ◽  
pp. 524-534 ◽  
Author(s):  
Makoto Michida ◽  
Hideaki Ishikawa ◽  
Takeshi Kaneda ◽  
Shinya Tatekabe ◽  
Yoshitaka Nakamura
Keyword(s):  
Manufacturing Process ◽  
Efficient Manufacturing
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