Advancing Base-Metal Catalysis: Development of a Screening Method for Nickel-Catalyzed Suzuki–Miyaura Reactions of Pharmaceutically Relevant Heterocycles

2021 ◽  
Author(s):  
Matthew J. Goldfogel ◽  
Xuelei Guo ◽  
Jeishla L. Meléndez Matos ◽  
John A. Gurak ◽  
Matthew V. Joannou ◽  
...  
Keyword(s):  
Base Metal ◽  
Screening Method ◽  
Metal Catalysis

Synthesis of Plakortolides E and I Enabled by Base Metal Catalysis

2021 ◽  
Author(s):  
Stefan Leisering ◽  
Alexandros Mavroskoufis ◽  
Patrick Voßnacker ◽  
Reinhold Zimmer ◽  
Mathias Christmann
Keyword(s):  
Base Metal ◽  
Metal Catalysis

Sterically encumbered β-diketonates and base metal catalysis

2019 ◽  
Vol 48 (28) ◽  
pp. 10714-10722 ◽  
Author(s):  
Sebastian M. Krajewski ◽  
Aaron S. Crossman ◽  
Eser S. Akturk ◽  
Tim Suhrbier ◽  
Steven J. Scappaticci ◽  
...  
Keyword(s):  
Base Metal ◽  
Coordination Complexes ◽  
Metal Coordination ◽  
Metal Catalysis ◽  
Sterically Hindered ◽  
Cu And Zn

Metal coordination complexes of the sterically hindered β-diketonate, 2,6-dimesitylbenzoyl pinacolone (esac), are reported for Co, Ni, Cu, and Zn.

scholarly journals Synthesis of Plakortolides E and I Enabled by Base Metal Catalysis

2021 ◽  
Author(s):  
Stefan Leisering ◽  
Alexandros Mavroskoufis ◽  
Patrick Voßnacker ◽  
Reinhold Zimmer ◽  
Mathias Christmann
Keyword(s):  
Natural Products ◽  
Transition Metals ◽  
Base Metal ◽  
Protecting Group ◽  
Efficient Synthesis ◽  
One Pot ◽  
Metal Catalysis ◽  
Bond Forming ◽  
Earth Abundant ◽  
Key Steps

A protecting-group-free synthesis of two endoperoxide natural products, plakortolide E and plakortolide I, is reported. Key-steps feature the use of earth-abundant transition metals, consisting of a vanadium-mediated epoxidation, an iron-catalyzed allylic substitution, and a cobalt-induced endoperoxide formation. Our approach combines redox-economy, chemoselective bond-forming reactions, and telescoping into one-pot operations to forge an overall efficient synthesis.

scholarly journals Synthesis of Plakortolides E and I Enabled by Base Metal Catalysis

2021 ◽  
Author(s):  
Stefan Leisering ◽  
Alexandros Mavroskoufis ◽  
Patrick Voßnacker ◽  
Reinhold Zimmer ◽  
Mathias Christmann
Keyword(s):  
Natural Products ◽  
Transition Metals ◽  
Base Metal ◽  
Protecting Group ◽  
Efficient Synthesis ◽  
One Pot ◽  
Metal Catalysis ◽  
Bond Forming ◽  
Earth Abundant ◽  
Key Steps

A protecting-group-free synthesis of two endoperoxide natural products, plakortolide E and plakortolide I, is reported. Key-steps feature the use of earth-abundant transition metals, consisting of a vanadium-mediated epoxidation, an iron-catalyzed allylic substitution, and a cobalt-induced endoperoxide formation. Our approach combines redox-economy, chemoselective bond-forming reactions, and telescoping into one-pot operations to forge an overall efficient synthesis.

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