scholarly journals Enhanced Performance of Polymeric 19F MRI Contrast Agents through Incorporation of Highly Water-Soluble Monomer MSEA

2018 ◽  
Vol 51 (15) ◽  
pp. 5875-5882 ◽  
Author(s):  
Changkui Fu ◽  
Cheng Zhang ◽  
Hui Peng ◽  
Felicity Han ◽  
Carly Baker ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Water Soluble ◽  
Mri Contrast ◽  
19F Mri

Fluorinated Water-Soluble Poly(2-oxazoline)s as Highly Sensitive 19F MRI Contrast Agents

2020 ◽  
Vol 53 (15) ◽  
pp. 6387-6395
Author(s):  
Ondrej Sedlacek ◽  
Daniel Jirak ◽  
Martin Vit ◽  
Natalia Ziołkowska ◽  
Olga Janouskova ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Water Soluble ◽  
Mri Contrast ◽  
Highly Sensitive ◽  
19F Mri ◽  
Soluble Poly

Water-soluble magnetic CoO nanocrystals functionalized with surfactants as T2-weighed MRI contrast agents in vitro

2011 ◽  
Vol 40 (14) ◽  
pp. 3616 ◽  
Author(s):  
Hong Yang ◽  
Hong Zhou ◽  
Cuixia Zhang ◽  
Xuejian Li ◽  
He Hu ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Water Soluble ◽  
Mri Contrast

Synthesis and characterization of a new water-soluble endohedral metallofullerene for MRI contrast agents

Carbon ◽  
2006 ◽  
Vol 44 (3) ◽  
pp. 496-500 ◽  
Author(s):  
Chun-Ying Shu ◽  
Li-Hua Gan ◽  
Chun-Ru Wang ◽  
Xin-long Pei ◽  
Hong-bin Han
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Water Soluble ◽  
Synthesis And Characterization ◽  
Mri Contrast ◽  
Endohedral Metallofullerene

Evaluation of Water-Soluble Metallofullerenes as MRI Contrast Agents

2002 ◽  
Vol 9 (2) ◽  
pp. S495-S497 ◽  
Author(s):  
Masafumi Okumura ◽  
Masahito Mikawa ◽  
Takashi Yokawa ◽  
Yoko Kanazawa ◽  
Haruhito Kato ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Water Soluble ◽  
Mri Contrast

Water-Soluble Gadofullerenes:  Toward High-Relaxivity, pH-Responsive MRI Contrast Agents

2005 ◽  
Vol 127 (2) ◽  
pp. 799-805 ◽  
Author(s):  
Éva Tóth ◽  
Robert D. Bolskar ◽  
Alain Borel ◽  
Gabriel González ◽  
Lothar Helm ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Water Soluble ◽  
Ph Responsive ◽  
Mri Contrast ◽  
High Relaxivity

Nanostructured magnetic nanocomposites as MRI contrast agents

2015 ◽  
Vol 3 (11) ◽  
pp. 2241-2276 ◽  
Author(s):  
Erwin Peng ◽  
Fenghe Wang ◽  
Jun Min Xue
Keyword(s):  
Contrast Agent ◽  
Contrast Agents ◽  
Magnetic Nanoparticle ◽  
Mri Contrast Agents ◽  
Water Soluble ◽  
Mri Contrast Agent ◽  
Magnetic Nanocomposites ◽  
Functional Coating ◽  
Mri Contrast ◽  
Nanoparticle Assemblies

The development of water-soluble nanostructured magnetic nanocomposites based on hydrophobic magnetic nanoparticle assemblies using an organic functional coating for MRI contrast agent applications was discussed.

Design of fluorinated hyperbranched polyether copolymers for 19F MRI nanotheranostics

2020 ◽  
Vol 11 (24) ◽  
pp. 3951-3963 ◽  
Author(s):  
Wanda Celentano ◽  
Giulia Neri ◽  
Francesco Distante ◽  
Min Li ◽  
Piergiorgio Messa ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
19F Mri ◽  
Hyperbranched Polyether ◽  
Drug Nanocarriers

19F MRI contrast agents and drug nanocarriers based on fluorinated hyperbranched polyether copolymers.

scholarly journals Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Asami Tsukiashi ◽  
Kil Sik Min ◽  
Hikaru Kitayama ◽  
Hiroaki Terasawa ◽  
Sosuke Yoshinaga ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Spin Crossover ◽  
Mri Contrast Agents ◽  
Water Soluble ◽  
Mri Contrast

scholarly journals Radical Dendrimers Based on Biocompatible Oligoethylene Glycol Dendrimers as Contrast Agents for MRI

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 772 ◽  
Author(s):  
Songbai Zhang ◽  
Vega Lloveras ◽  
Daniel Pulido ◽  
Flonja Liko ◽  
Luiz F. Pinto ◽  
...  
Keyword(s):  
Contrast Agents ◽  
First Generation ◽  
Water Solubility ◽  
High Water ◽  
Mri Contrast Agents ◽  
The Body ◽  
Water Soluble ◽  
Mri Contrast ◽  
Oligoethylene Glycol ◽  
Magnetic Resonance Imaging Mri

Finding alternatives to gadolinium (Gd)-based contrast agents (CA) with the same or even better paramagnetic properties is crucial to overcome their established toxicity. Herein we describe the synthesis and characterization of entirely organic metal-free paramagnetic macromolecules based on biocompatible oligoethylene glycol dendrimers fully functionalized with 5 and 20 organic radicals (OEG Gn-PROXYL (n = 0, 1) radical dendrimers) with the aim to be used as magnetic resonance imaging (MRI) contrast agents. Conferring high water solubility on such systems is often a concern, especially in large generation dendrimers. Our approach to overcome such an issue in this study is by synthesizing dendrimers with highly water-soluble branches themselves. In this work, we show that the highly water-soluble OEG Gn-PROXYL (n = 0, 1) radical dendrimers obtained showed properties that convert them in good candidates to be studied as contrast agents for MRI applications like diagnosis and follow-up of infectious diseases, among others. Importantly, with the first generation radical dendrimer, a similar r1 relaxivity value (3.4 mM−1s−1) in comparison to gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) used in clinics (3.2 mM−1s−1, r.t. 7T) has been obtained, and it has been shown to not be cytotoxic, avoiding the toxicity risks associated with the unwanted accumulation of Gd in the body.

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