A Versatile Synthetic Platform for Discrete Oligo- and Polyesters Based on Optimized Protective Groups Via Iterative Exponential Growth

2021 ◽  
Author(s):  
Suhua Duan ◽  
Xiaojie Yang ◽  
Ze Yang ◽  
Yuxin Liu ◽  
Qiunan Shi ◽  
...  
Keyword(s):  
Exponential Growth ◽  
Protective Groups

Design emergence in Morocco as an African country: a pending institutionalization

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Nabil EL HILALI
Keyword(s):  
Institutional Theory ◽  
Exponential Growth ◽  
African Country ◽  
Political Stability ◽  
The State ◽  
Design Management ◽  
Specific Context ◽  
Developed Economies ◽  
Design Value ◽  
Specific Country

If design management is worldwide institutionalized especially in developed economies, little is known about African design even though the continent is becoming an attractive economy thanks to his exponential growth and more political stability. Oriented toward one specific country: Morocco, this study through a questioning embedded in institutional theory brings an overview about design in a specific context. This research captures design management emergence in Morocco by spotting the light on the state of design institutionalization toward the creation of design value.

Visible Light-Mediated Oxidative Debenzylation

2020 ◽  
Author(s):  
Cristian Cavedon ◽  
Eric T. Sletten ◽  
Amiera Madani ◽  
Olaf Niemeyer ◽  
Peter H. Seeberger ◽  
...  
Keyword(s):  
Reaction Time ◽  
Visible Light ◽  
Functional Groups ◽  
Continuous Flow ◽  
Protecting Groups ◽  
Benzyl Ether ◽  
Complex Molecules ◽  
Protective Groups ◽  
Benzyl Ethers ◽  
Harsh Conditions

Protecting groups are key in the synthesis of complex molecules such as carbohydrates to distinguish functional groups of similar reactivity. The harsh conditions required to cleave stable benzyl ether protective groups are not compatible with many other protective and functional groups. The mild, visible light-mediated debenzylation disclosed here renders benzyl ethers orthogonal protective groups. Key to success is the use of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as stoichiometric or catalytic photooxidant such that benzyl ethers can be cleaved in the presence of azides, alkenes, and alkynes. The reaction time for this transformation can be reduced from hours to minutes in continuous flow. <br>

Catalytic Synthesis of Cyclic Guanidines via Hydrogen Atom Transfer and Radical-Polar Crossover

2020 ◽  
Author(s):  
Shunya Ohuchi ◽  
Hiroki Koyama ◽  
Hiroki Shigehisa
Keyword(s):  
Hydrogen Atom ◽  
Functional Group ◽  
Hydrogen Atom Transfer ◽  
Catalytic Synthesis ◽  
Membered Ring ◽  
Biologically Active ◽  
Atom Transfer ◽  
Powerful Method ◽  
Protective Groups ◽  
The Common

A catalytic synthesis of cyclic guanidines, which are found in many biologically active compounds and natu-ral products, was developed, wherein transition-metal hydrogen atom transfer and radical-polar crossover were employed. This mild and functional-group tolerant process enabled the cyclization of alkenyl guanidines bearing common protective groups, such as Cbz and Boc. This powerful method not only provided the common 5- and 6-membered rings but also an unusual 7-membered ring. The derivatization of the products afforded various heterocycles. We also investigated the se-lective cyclization of mono-protected or hetero-protected (TFA and Boc) alkenyl guanidines and their further derivatiza-tions.

Won’t you self-confine for two weeks to save a town? Delaying exponential growth.

2020 ◽  
Author(s):  
Michal Levy ◽  
David Leiser ◽  
Avia Spivak
Keyword(s):  
Exponential Growth ◽  
Short Delay

Much of the communication around the current pandemic stresses the exponential growth in the number of infections. We observe that this approach may backfire: it becomes difficult to convince people to obey strict constraints when what will be achieved is merely a short delay in that growth. Based on a method we successfully used in a context of pension savings, we suggest how best to frame the gains of delaying tactics

A Facile, Efficient and Selective Deprotection of P - Methoxy Benzyl Ethers Using Zinc (II) Trifluoromethanesulfonate

2019 ◽  
Vol 16 (12) ◽  
pp. 955-958
Author(s):  
Reddymasu Sireesha ◽  
Reddymasu Sreenivasulu ◽  
Choragudi Chandrasekhar ◽  
Mannam Subba Rao
Keyword(s):  
Room Temperature ◽  
Protecting Groups ◽  
Side Reactions ◽  
Reaction Conditions ◽  
Acid Sensitivity ◽  
Time Period ◽  
Protective Groups ◽  
Benzyl Ethers ◽  
Last Stage ◽  
Zinc Triflate

: Deprotection is significant and conducted over mild reaction conditions, in order to restrict any more side reactions with sensitive functional groups as well as racemization or epimerization of stereo center because the protective groups are often cleaved at last stage in the synthesis. P - Methoxy benzyl (PMB) ether appears unique due to its easy introduction and removal than the other benzyl ether protecting groups. A facile, efficient and highly selective cleavage of P - methoxy benzyl ethers was reported by using 20 mole% Zinc (II) Trifluoromethanesulfonate at room temperature in acetonitrile solvent over 15-120 min. time period. To study the generality of this methodology, several PMB ethers were prepared from a variety of substrates having different protecting groups and subjected to deprotection of PMB ethers using Zn(OTf)2 in acetonitrile. In this methodology, zinc triflate cleaves only PMB ethers without affecting acid sensitivity, base sensitivity and also chiral epoxide groups.

scholarly journals 2nd Edition of Instrumenting Smart City Applications with Big Sensing and Earth Observatory Data: Tools, Methods and Techniques

2021 ◽  
Vol 13 (7) ◽  
pp. 1310
Author(s):  
Gabriele Bitelli ◽  
Emanuele Mandanici
Keyword(s):  
High Resolution ◽  
Exponential Growth ◽  
Smart City ◽  
Earth Observation ◽  
Urban Environments ◽  
Observation Data ◽  
High Resolution Imagery ◽  
Observatory Data ◽  
Methods And Techniques ◽  
Earth Observation Data

The exponential growth in the volume of Earth observation data and the increasing quality and availability of high-resolution imagery are increasingly making more applications possible in urban environments [...]

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