Handedness Inversion in Chiral Nematic (Ethyl)cellulose Solutions: Effects of Substituents and Temperature

2021 ◽  
Author(s):  
Yoshiyuki Nishio ◽  
Takayuki Nada ◽  
Takuma Hirata ◽  
Shinpei Fujita ◽  
Kazuki Sugimura ◽  
...  
Keyword(s):  
Ethyl Cellulose ◽  
Chiral Nematic

Preparation of glycolic acid ethyl cellulose microspheres

2013 ◽  
Vol 32 (5) ◽  
pp. 532-535
Author(s):  
Xin-xia WANG ◽  
Ya-ling LIN ◽  
Guo-qing ZHANG ◽  
Gui-chen ZHOU ◽  
Ying LU ◽  
...  
Keyword(s):  
Ethyl Cellulose ◽  
Glycolic Acid

Formulation and Evaluation of Bilayer Sustained Release Tablets of Salbutamol and Theophylline

2009 ◽  
Vol 2 (3) ◽  
pp. 638-646
Author(s):  
R. Nagaraju ◽  
Rajesh Kaza
Keyword(s):  
Ethyl Cellulose ◽  
Xanthan Gum ◽  
Dosage Forms ◽  
In Vitro Dissolution ◽  
Dissolution Studies ◽  
Sustained Release Tablets ◽  
Dissolution Apparatus ◽  
Single Dosage

Salbutamol and theophylline are available in conventional dosage forms, administered four times a day, leading to saw tooth kinetics and resulting in ineffective therapy. The combination of these two drugs in a single dosage form will enhance the patient compliance and prolong bronchodilation. Various polymers, such as hydroxy propyl methylcellulose K4M (HPMC- K4M), hydroxy propyl methylcellulose K100M (HPMC- K100M), xanthan gum, ethyl cellulose and hydroxy propyl methylcellulose phthalate (HPMC-P) were studied. HPMC-P and HPMC- K4M were found to be best in controlling the release. In-vitro dissolution studies were carried out for all the bi-layered tablets developed using USP dissolution apparatus type 2 (paddle). It was found that the tablet FB15-FW3 showed 50% release of salbutamol in first hour and the remaining was released for eight hours. However, theophylline was found to be released as per the USP specifications. The IR spectrum was taken for FB15-FW3 formulation and it revealed that there is no disturbance in the principal peaks of pure drugs salbutamol and theophylline. This further confirms the integrity of pure drugs and no incompatibility of them with excipients. Also, formulation of FB15-FW3 has shown required release pattern and complies with all the evaluated parameters and comparable to the marketed formulation.

Design and Optimization of Chronotherapeutic Dosage Form for the Treatment of Angina Pectoris

2020 ◽  
Vol 10 ◽  
Author(s):  
Rupali Singh ◽  
Rishabha Malviya
Keyword(s):  
Drug Delivery ◽  
Angina Pectoris ◽  
Ethyl Cellulose ◽  
Dosage Form ◽  
Cellulose Solution ◽  
Specific Drug ◽  
Pharmaceutical Dosage Form ◽  
Weight Variation ◽  
Short Period ◽  
Time Specific

Background: The chronotherapy concept attains considerable focus towards itself due to its pulsatile fashion rather than continuous delivery. The delivery of the right amount of drug to the target organ at the most appropriate time is fulfilled by using the chronotherapeutic dosage form. Aim: The present study aims to develop and evaluate a chronotherapeutic drug delivery system by using natural polymer for time specific drug delivery at the target site. Material and Method: Tamarind seed polysaccharide was extracted and used in the preparation of core tablets. Nine formulations of core tablets were prepared with nifedipine at 5 tonnes of pressure on 6 mm punch. The core tablets were prepared by using the compression coating method. The three batches F1, F2 and F3 were prepared by using tamarind gum in different concentration i.e. 45%, 22.5% and 67.5% respectively and compressed at 8 tonnes of pressure on 12 mm of punch. The finally compressed tablet was coated with different concentrations of ethyl cellulose in which isopropyl alcohol used as a solvent. In a controlled medium, a stability study was performed to evaluate the physical appearance, drug content and release of the prepared core tablet. Result: All the nine formulations of tablets were prepared successfully and the evaluation studies (thickness, weight variation, hardness, friability etc.) revealed that all the formulations were within the official range. The release study of the drug revealed that the formulation F7 containing 67.5% of tamarind polymer, coated with 2%, 4% and 5% of ethyl cellulose solution released 59.68±1.03% (Q50%) drug within 5 h whereas, 87.09±2.08% (Q80%) within 6 h and within 12 h 97.74±2.19% of the drug was released. The formulation F7 was found to be more effective as it released the maximum amount of drug in a short period as compared with other formulations. Conclusion: The coating of core tablets allowed to prepare pharmaceutical dosage form for time specific drug delivery. These chronotherapeutic core tablets can be used for the treatment of angina pectoris and hypertension etc.

Complex Formation Between Chymotrypsin and Ethyl Cellulose as a Means to Solubilize the Enzyme in Active Form in Toluene

Biocatalysis ◽  
1992 ◽  
Vol 6 (4) ◽  
pp. 291-305 ◽  
Author(s):  
Marina Otamiri ◽  
Patrick Adlercreutz ◽  
Bo Mattiasson
Keyword(s):  
Complex Formation ◽  
Ethyl Cellulose ◽  
Active Form

scholarly journals Reusable Hyperbranched Polyethylenimine-Functionalized Ethyl Cellulose Film for the Removal of Phosphate with Easy Separation

ACS Omega ◽  
2020 ◽  
Author(s):  
Enmin Zong ◽  
Binlu Guo ◽  
Jiayao Yang ◽  
Chao Shi ◽  
Shengtao Jiang ◽  
...  
Keyword(s):  
Ethyl Cellulose ◽  
Cellulose Film
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