scholarly journals Generation of an Interactome for the Tetratricopeptide Repeat Domain of O-GlcNAc Transferase Indicates a Role for the Enzyme in Intellectual Disability

2020 ◽  
Author(s):  
Hannah M. Stephen ◽  
Jeremy L. Praissman ◽  
Lance Wells
Keyword(s):  
Intellectual Disability ◽  
Tetratricopeptide Repeat ◽  
Repeat Domain ◽  
Tetratricopeptide Repeat Domain ◽  
Glcnac Transferase

scholarly journals Protein substrates engage the lumen of O-GlcNac transferase’s tetratricopeptide repeat domain in different ways

2020 ◽  
Author(s):  
Cassandra M. Joiner ◽  
Forrest A. Hammel ◽  
John Janetzko ◽  
Suzanne Walker
Keyword(s):  
Tetratricopeptide Repeat ◽  
Substrate Selection ◽  
Post Translational Modification ◽  
Protein Substrates ◽  
Cytoplasmic Proteins ◽  
C Terminus ◽  
Glycosylation Sites ◽  
Repeat Domain ◽  
Tetratricopeptide Repeat Domain ◽  
Glcnac Transferase

ABSTRACTGlycosylation of nuclear and cytoplasmic proteins is an essential post-translational modification in mammals. O-GlcNAc transferase (OGT), the sole enzyme responsible for this modification, glycosylates over a thousand unique nuclear and cytoplasmic substrates. How OGT selects its substrates is a fundamental question that must be answered to understand OGT’s unusual biology. OGT contains a long tetratricopeptide repeat (TPR) domain that has been implicated in substrate selection, but there is almost no information about how changes to this domain affect glycosylation of individual substrates. Here, we used proteome-wide glycosylation profiling and probed glycosylation of selected purified substrates to show that asparagine and aspartate ladders that extend the full length of OGT’s TPR lumen control substrate glycosylation. We also found that substrates with glycosylation sites close to the C-terminus bypass lumenal binding. Our findings demonstrate that substrates can engage OGT in a variety of different ways for glycosylation.

scholarly journals C-terminal Sequences outside the Tetratricopeptide Repeat Domain of FKBP51 and FKBP52 Cause Differential Binding to Hsp90

2003 ◽  
Vol 278 (19) ◽  
pp. 17388-17394 ◽  
Author(s):  
Joyce Cheung-Flynn ◽  
Patricia J. Roberts ◽  
Daniel L. Riggs ◽  
David F. Smith
Keyword(s):  
Tetratricopeptide Repeat ◽  
Repeat Domain ◽  
Differential Binding ◽  
Tetratricopeptide Repeat Domain

scholarly journals Hybrid Sterility in Rice (Oryza sativaL.) Involves the Tetratricopeptide Repeat Domain Containing Protein

Genetics ◽  
2016 ◽  
Vol 203 (3) ◽  
pp. 1439-1451 ◽  
Author(s):  
Yang Yu ◽  
Zhigang Zhao ◽  
Yanrong Shi ◽  
Hua Tian ◽  
Linglong Liu ◽  
...  
Keyword(s):  
Hybrid Sterility ◽  
Tetratricopeptide Repeat ◽  
Repeat Domain ◽  
Tetratricopeptide Repeat Domain

Biallelic Mutations in Tetratricopeptide Repeat Domain 26 ( Intraflagellar Transport 56 ) Cause Severe Biliary Ciliopathy in Humans

Hepatology ◽  
2020 ◽  
Vol 71 (6) ◽  
pp. 2067-2079 ◽  
Author(s):  
Ranad Shaheen ◽  
Saud Alsahli ◽  
Nour Ewida ◽  
Fatema Alzahrani ◽  
Hanan E. Shamseldin ◽  
...  
Keyword(s):  
Intraflagellar Transport ◽  
Tetratricopeptide Repeat ◽  
Repeat Domain ◽  
Tetratricopeptide Repeat Domain ◽  
Biallelic Mutations

scholarly journals Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Lee Wei Lim ◽  
Smeeta Shrestha ◽  
Yu Zuan Or ◽  
Shawn Zheng Kai Tan ◽  
Hwa Hwa Chung ◽  
...  
Keyword(s):  
Tetratricopeptide Repeat ◽  
Female Mice ◽  
Repeat Domain ◽  
Tetratricopeptide Repeat Domain

1H, 13C and 15N resonance assignments of the backbone and methyl groups of the 24 kDa tetratricopeptide repeat domain in p67phox

2005 ◽  
Vol 32 (2) ◽  
pp. 176-176
Author(s):  
Shinichi Yoshida ◽  
Kenji Ogura ◽  
Masashi Yokochi ◽  
Satoru Yuzawa ◽  
Masataka Horiuchi ◽  
...  
Keyword(s):  
Resonance Assignments ◽  
Tetratricopeptide Repeat ◽  
Methyl Groups ◽  
Repeat Domain ◽  
Tetratricopeptide Repeat Domain
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