Red-Emissive Carbon Quantum Dots for Nuclear Drug Delivery in Cancer Stem Cells

2020 ◽  
Vol 11 (4) ◽  
pp. 1357-1363 ◽  
Author(s):  
Wen Su ◽  
Ruihua Guo ◽  
Fanglong Yuan ◽  
Yunchao Li ◽  
Xiaohong Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Quantum Dots ◽  
Cancer Stem Cells ◽  
Carbon Quantum Dots

scholarly journals Correction to “Red-Emissive Carbon Quantum Dots for Nuclear Drug Delivery in Cancer Stem Cells”

2020 ◽  
Vol 11 (11) ◽  
pp. 4345-4345 ◽  
Author(s):  
Wen Su ◽  
Ruihua Guo ◽  
Fanglong Yuan ◽  
Yunchao Li ◽  
Xiaohong Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cells ◽  
Quantum Dots ◽  
Cancer Stem Cells ◽  
Carbon Quantum Dots

scholarly journals Effective Gold Nanoparticle-Antibody-Mediated Drug Delivery for Photodynamic Therapy of Lung Cancer Stem Cells

2020 ◽  
Vol 21 (11) ◽  
pp. 3742
Author(s):  
Anine Crous ◽  
Heidi Abrahamse
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Stem Cells ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Stem Cells ◽  
Lung Cancer Mortality ◽  
Drug Induced ◽  
Biochemical Assays ◽  
Lung Cancer Stem Cells

Cancer stem cells (CSCs) are a leading contributor to lung cancer mortality rates. CSCs are responsible for tumor growth and recurrence through inhibition of drug-induced cell death, decreasing the effect of traditional cancer therapy and photodynamic therapy (PDT). PDT can be improved to successfully treat lung cancer by using gold nanoparticles (AuNPs), due to their size and shape, which have been shown to facilitate drug delivery and retention, along with the targeted antibody (Ab) mediated selection of CSCs. In this study, a nanobioconjugate (NBC) was constructed, using a photosensitizer (PS) (AlPcS4Cl), AuNPs and Abs. The NBC was characterized, using spectroscopy techniques. Photodynamic effects of the NBC on lung CSCs was evaluated, using biochemical assays 24 h post-irradiation, in order to establish its anticancer effect. Results showed successful conjugation of the nanocomposite. Localization of the NBC was seen to be in integral organelles involved in cell homeostasis. Biochemical responses of lung CSCs treated using AlPcS4Cl-AuNP and AlPcS4Cl-AuNP-Ab showed significant cell toxicity and cell death, compared to free AlPcS4Cl. The PDT effects were enhanced when using the NBC, showing significant lung CSC destruction to the point of eradication.

scholarly journals Colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles

RSC Advances ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 973-985 ◽  
Author(s):  
Manali Haniti Mohd-Zahid ◽  
Rohimah Mohamud ◽  
Che Azurahanim Che Abdullah ◽  
JitKang Lim ◽  
Halima Alem ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Stem Cells ◽  
Gold Nanoparticles ◽  
Cancer Stem Cells ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
Colorectal Cancer Stem Cells

The proposed schematic mechanism via which 5-fluorouracil-loaded gold nanoparticles conjugated with CD133 antibody target colorectal cancer stem cells.

scholarly journals EXTH-77. LIGAND CONJUGATED QUANTUM DOTS FOR THE DETECTION OF CANCER STEM CELLS AND EXOSOMES

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi90-vi90
Author(s):  
A B Madhankumar ◽  
Oliver Mrowczynski ◽  
Becky Slagle-Webb ◽  
Brad Zacharia ◽  
Michael Glantz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Quantum Dots ◽  
Cancer Stem Cells
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