Defining Cyclic–Acyclic Exciton Transition at the Single-Molecule Level: Size-Dependent Conformational Heterogeneity and Exciton Delocalization in Ethynylene-Bridged Cyclic Oligothiophenes

2016 ◽  
Vol 7 (7) ◽  
pp. 1260-1266 ◽  
Author(s):  
Kyu Hyung Park ◽  
Jae-Won Cho ◽  
Tae-Woo Kim ◽  
Hideyuki Shimizu ◽  
Kazumi Nakao ◽  
...  
Keyword(s):  
Single Molecule ◽  
Conformational Heterogeneity ◽  
Exciton Transition ◽  
Single Molecule Level ◽  
Size Dependent

A stochastic theoretical approach to study the size-dependent catalytic activity of a metal nanoparticle at the single molecule level

2017 ◽  
Vol 19 (13) ◽  
pp. 8889-8895 ◽  
Author(s):  
Divya Singh ◽  
Srabanti Chaudhury
Keyword(s):  
Catalytic Activity ◽  
Single Molecule ◽  
Time Distribution ◽  
First Passage Time ◽  
Theoretical Method ◽  
Passage Time ◽  
Metal Nanoparticle ◽  
First Passage ◽  
Single Molecule Level ◽  
Size Dependent

We present a theoretical method based on the first passage time distribution formalism to study the size-dependent catalytic activity of metal nanoparticle at the single molecule level.

Size-Dependent Catalytic Activity and Dynamics of Gold Nanoparticles at the Single-Molecule Level

2010 ◽  
Vol 132 (1) ◽  
pp. 138-146 ◽  
Author(s):  
Xiaochun Zhou ◽  
Weilin Xu ◽  
Guokun Liu ◽  
Debashis Panda ◽  
Peng Chen
Keyword(s):  
Gold Nanoparticles ◽  
Catalytic Activity ◽  
Single Molecule ◽  
Single Molecule Level ◽  
Size Dependent

scholarly journals Conformational heterogeneity of molecules physisorbed on a gold surface at room temperature

2021 ◽  
Author(s):  
Mingu Kang ◽  
Hyun Woo Kim ◽  
Elham Oleiki ◽  
Yeonjeong Koo ◽  
Hyeongwoo Lee ◽  
...  
Keyword(s):  
Single Molecule ◽  
Density Functional ◽  
Room Temperature ◽  
Gold Surface ◽  
Chemical Imaging ◽  
Conformational Heterogeneity ◽  
Single Molecule Level ◽  
Cresyl Blue ◽  
Tip Enhanced Raman Spectroscopy ◽  
Spectroscopy Studies

Abstract A quantitative single-molecule tip-enhanced Raman spectroscopy (TERS) study at room temperature remained a challenge due to the rapid structural dynamics of molecules exposed to air. Here, we demonstrate the hyperspectral TERS imaging of single or a few brilliant cresyl blue (BCB) molecules at room temperature, along with quantitative spectral analyses. Robust chemical imaging is enabled by the freeze-frame approach using a thin Al2O3 capping layer, which suppresses spectral diffusions and inhibits chemical reactions and contaminations in air. For the molecules resolved spatially in the TERS image, a clear Raman peak variation up to 7.5 cm-1 is observed, which cannot be found in molecular ensembles. From density functional theory-based quantitative analyses of the varied TERS peaks, we reveal the conformational heterogeneity at the single-molecule level. This work provides a facile way to investigate the single-molecule properties in interacting media, expanding the scope of single-molecule vibrational spectroscopy studies.

Atomic Force Microscopy (AFM) for Topography and Recognition Imaging at Single Molecule Level

2013 ◽  
pp. 102-112
Author(s):  
Memed Duman ◽  
Andreas Ebner ◽  
Christian Rankl ◽  
Jilin Tang ◽  
Lilia A. Chtcheglova ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Single Molecule ◽  
Single Molecule Level ◽  
Force Microscopy ◽  
Atomic Force ◽  
Recognition Imaging

Curaxin-Induced DNA Topology Alterations Trigger the Distinct Binding Response of CTCF and FACT at the Single-Molecule Level

Biochemistry ◽  
2021 ◽  
Vol 60 (7) ◽  
pp. 494-499
Author(s):  
Ke Lu ◽  
Cuifang Liu ◽  
Yinuo Liu ◽  
Anfeng Luo ◽  
Jun Chen ◽  
...  
Keyword(s):  
Single Molecule ◽  
Dna Topology ◽  
Single Molecule Level

scholarly journals Power-law behavior of transcription factor dynamics at the single-molecule level implies a continuum affinity model

2021 ◽  
Author(s):  
David A Garcia ◽  
Gregory Fettweis ◽  
Diego M Presman ◽  
Ville Paakinaho ◽  
Christopher Jarzynski ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Single Molecule ◽  
Power Law ◽  
Dwell Time ◽  
Specific Binding ◽  
Power Law Distribution ◽  
Single Molecule Level ◽  
Binding Behavior ◽  
Chromatin Template ◽  
Nuclear Domains

Abstract Single-molecule tracking (SMT) allows the study of transcription factor (TF) dynamics in the nucleus, giving important information regarding the diffusion and binding behavior of these proteins in the nuclear environment. Dwell time distributions obtained by SMT for most TFs appear to follow bi-exponential behavior. This has been ascribed to two discrete populations of TFs—one non-specifically bound to chromatin and another specifically bound to target sites, as implied by decades of biochemical studies. However, emerging studies suggest alternate models for dwell-time distributions, indicating the existence of more than two populations of TFs (multi-exponential distribution), or even the absence of discrete states altogether (power-law distribution). Here, we present an analytical pipeline to evaluate which model best explains SMT data. We find that a broad spectrum of TFs (including glucocorticoid receptor, oestrogen receptor, FOXA1, CTCF) follow a power-law distribution of dwell-times, blurring the temporal line between non-specific and specific binding, suggesting that productive binding may involve longer binding events than previously believed. From these observations, we propose a continuum of affinities model to explain TF dynamics, that is consistent with complex interactions of TFs with multiple nuclear domains as well as binding and searching on the chromatin template.

Magnetic Nanoparticles as a Tool for Remote DNA Manipulations at a Single-Molecule Level

2021 ◽  
Vol 13 (12) ◽  
pp. 14458-14469
Author(s):  
Aleksey A. Nikitin ◽  
Anton Yu Yurenya ◽  
Timofei S. Zatsepin ◽  
Ilya O. Aparin ◽  
Vladimir P. Chekhonin ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Single Molecule ◽  
Single Molecule Level
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