scholarly journals Formic Acid Synthesis in a Water–Mineral System: Major Role of the Interface

2020 ◽  
Vol 124 (9) ◽  
pp. 5125-5131
Author(s):  
Sara Laporte ◽  
Fabio Pietrucci ◽  
François Guyot ◽  
A. Marco Saitta
Keyword(s):  
Formic Acid ◽  
Acid Synthesis ◽  
Mineral System

The Role of Chromohalobacter on Transport of Lanthanides and Cesium in the Dolomite Mineral System

2017 ◽  
Author(s):  
Frances Zengotita ◽  
Hilary Palmer Emerson ◽  
Timothy M. Dittrich ◽  
Juliet S. Swanson ◽  
Donald T. Reed
Keyword(s):  
Mineral System

Disclosing the role of Gold on Palladium ‐ Gold alloyed supported catalysts in formic acid decomposition

ChemCatChem ◽  
2021 ◽  
Author(s):  
Alberto Villa ◽  
Ilaria Barlocco ◽  
Sofia Capelli ◽  
Xiuyuan Lu ◽  
Silvio Bellomi ◽  
...  
Keyword(s):  
Formic Acid ◽  
Supported Catalysts ◽  
Acid Decomposition ◽  
Formic Acid Decomposition

scholarly journals FSMP-15. EVALUATING THE ROLE OF LONG-CHAIN FATTY ACID METABOLISM IN PROMOTING GLIOBLASTOMA GROWTH

2021 ◽  
Vol 3 (Supplement_1) ◽  
pp. i19-i19
Author(s):  
Divya Ravi ◽  
Carmen del Genio ◽  
Haider Ghiasuddin ◽  
Arti Gaur
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Survival Rate ◽  
Tumor Progression ◽  
Acid Synthesis ◽  
Normal Brain ◽  
Acid Uptake ◽  
Exogenous Fatty Acid ◽  
Long Chain

Abstract Glioblastomas (GBM) or Stage IV gliomas, are the most aggressive of primary brain tumors and are associated with high mortality and morbidity. Patients diagnosed with this lethal cancer have a dismal survival rate of 14 months and a 5-year survival rate of 5.6% despite a multimodal therapeutic approach, including surgery, radiation therapy, and chemotherapy. Aberrant lipid metabolism, particularly abnormally active de novo fatty acid synthesis, is recognized to have a key role in tumor progression and chemoresistance in cancers. Previous studies have reported a high expression of fatty acid synthase (FASN) in patient tumors, leading to multiple investigations of FASN inhibition as a treatment strategy. However, none of these have developed as efficacious therapies. Furthermore, when we profiled FASN expression using The Cancer Genome Atlas (TCGA) we determined that high FASN expression in GBM patients did not confer a worse prognosis (HR: 1.06; p-value: 0.51) and was not overexpressed in GBM tumors compared to normal brain. Therefore, we need to reexamine the role of exogenous fatty acid uptake over de novofatty acid synthesis as a potential mechanism for tumor progression. Our study aims to measure and compare fatty acid oxidation (FAO) of endogenous and exogenous fatty acids between GBM patients and healthy controls. Using TCGA, we have identified the overexpression of multiple enzymes involved in mediating the transfer and activation of long-chain fatty acids (LCFA) in GBM tumors compared to normal brain tissue. We are currently conducting metabolic flux studies to (1) assess the biokinetics of LCFA degradation and (2) establish exogenous versus endogenous LCFA preferences between patient-derived primary GBM cells and healthy glial and immune cells during steady state and glucose-deprivation.

scholarly journals Role of Folic Acid and Energy Intake in Nucleic Acid Synthesis

1959 ◽  
Vol 234 (3) ◽  
pp. 625-627
Author(s):  
Ranjan Mehta ◽  
David A. Vaughan ◽  
Shreepad R. Wagle ◽  
Kendall D. Barbee ◽  
S.P. Mistry ◽  
...  
Keyword(s):  
Folic Acid ◽  
Nucleic Acid ◽  
Energy Intake ◽  
Acid Synthesis ◽  
Nucleic Acid Synthesis

scholarly journals Selectivity Effects in Bimetallic Catalysis: Role of the Metal Sites in the Decomposition of Formic Acid into H2and CO2by the Coinage Metal Binuclear Complexes [dppmMM′(H)]+

ChemCatChem ◽  
2017 ◽  
Vol 9 (7) ◽  
pp. 1298-1302 ◽  
Author(s):  
Athanasios Zavras ◽  
Marjan Krstić ◽  
Philippe Dugourd ◽  
Vlasta Bonačić-Koutecký ◽  
Richard A. J. O'Hair
Keyword(s):  
Formic Acid ◽  
Binuclear Complexes ◽  
Coinage Metal ◽  
Bimetallic Catalysis

Citral, an inhibitor of retinoic acid synthesis, modifies pattern formation during limb regeneration in the axolotl Ambystoma mexicanum

1999 ◽  
Vol 77 (11) ◽  
pp. 1835-1837 ◽  
Author(s):  
Steven R Scadding
Keyword(s):  
Retinoic Acid ◽  
Pattern Formation ◽  
Limb Regeneration ◽  
Acid Synthesis ◽  
Ambystoma Mexicanum

While the effects of exogenous retinoids on amphibian limb regeneration have been studied extensively, the role of endogenous retinoids is not clear. Hence, I wished to investigate the role of endogenous retinoic acid during axolotl limb regeneration. Citral is a known inhibitor of retinoic acid synthesis. Thus, I treated regenerating limbs of the larval axolotl Ambystoma mexicanum with citral. The result of this inhibition of retinoic acid synthesis was that limb regeneration became extremely irregular and hypomorphic, with serious pattern defects, or was inhibited altogether. I conclude that endogenous retinoic acid plays an important role in pattern formation during limb regeneration.

scholarly journals The Role of Succinate in the Regulation of Fatty Acid Synthesis by Heart Mitochondria

1967 ◽  
Vol 242 (18) ◽  
pp. 4013-4022 ◽  
Author(s):  
Arthur F. Whereat ◽  
Franklin E. Hull ◽  
Margaret W. Orishimo ◽  
Joseph L. Rabinowitz
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Acid Synthesis ◽  
Heart Mitochondria
Sign in / Sign up

Export Citation Format

Share Document