Effect of Dipolar Interactions on the Assembly Process of Iron Oxide Nanoparticles Promoted by the CuAAC “Click” Chemistry Reaction

2019 ◽  
Vol 123 (45) ◽  
pp. 27927-27936 ◽  
Author(s):  
Mathias Dolci ◽  
Yu-ting Lei ◽  
Lise-Marie Lacroix ◽  
Céline Kiefer ◽  
Cédric Leuvrey ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Click Chemistry ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Assembly Process ◽  
Dipolar Interactions

Synthesis and characterization of multifunctional superparamagnetic iron oxide nanoparticles (SPION)/C60 nanocomposites assembled by fullerene–amine click chemistry

RSC Advances ◽  
2016 ◽  
Vol 6 (74) ◽  
pp. 70374-70382 ◽  
Author(s):  
Manuel Cano ◽  
Rebeca Núñez-Lozano ◽  
Yves Dumont ◽  
Chantal Larpent ◽  
Guillermo de la Cueva-Méndez
Keyword(s):  
Iron Oxide ◽  
Click Chemistry ◽  
Iron Oxide Nanoparticles ◽  
Antioxidant Activities ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Synthesis And Characterization ◽  
Oxide Nanoparticles

We used fullerene–amine click chemistry for the fabrication of SPION/C60 nanocomposites that bring together the superparamagnetic character conferred by the SPION-core and the photochemical and antioxidant activities provided by the C60.

Effects of inter- and intra-aggregate magnetic dipolar interactions on the magnetic heating efficiency of iron oxide nanoparticles

2016 ◽  
Vol 18 (16) ◽  
pp. 10954-10963 ◽  
Author(s):  
J. G. Ovejero ◽  
D. Cabrera ◽  
J. Carrey ◽  
T. Valdivielso ◽  
G. Salas ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Dipolar Interactions ◽  
Heating Efficiency ◽  
Magnetic Heating ◽  
Diagnostic Agents

Iron oxide nanoparticles have found biomedical applications as therapeutic and/or diagnostic agents.

Effects of Nanostructure and Dipolar Interactions on Magnetohyperthermia in Iron Oxide Nanoparticles

2016 ◽  
Vol 120 (23) ◽  
pp. 12796-12809 ◽  
Author(s):  
J. M. Orozco-Henao ◽  
D. F. Coral ◽  
D. Muraca ◽  
O. Moscoso-Londoño ◽  
P. Mendoza Zélis ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Dipolar Interactions

2D assembly of non-interacting magnetic iron oxide nanoparticles via“click” chemistry

2011 ◽  
Vol 47 (43) ◽  
pp. 11954 ◽  
Author(s):  
Delphine Toulemon ◽  
Benoît P. Pichon ◽  
Xavier Cattoën ◽  
Michel Wong Chi Man ◽  
Sylvie Begin-Colin
Keyword(s):  
Iron Oxide ◽  
Click Chemistry ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide

Boronic acid-functionalized iron oxide magnetic nanoparticles via distillation–precipitation polymerization and thiol–yne click chemistry for the enrichment of glycoproteins

2018 ◽  
Vol 42 (21) ◽  
pp. 17331-17338 ◽  
Author(s):  
Changfen Bi ◽  
Sitong Zhang ◽  
Yiliang Li ◽  
Xiwen He ◽  
Langxing Chen ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Click Chemistry ◽  
Iron Oxide Nanoparticles ◽  
Boronic Acid ◽  
Phenylboronic Acid ◽  
Precipitation Polymerization ◽  
Oxide Nanoparticles ◽  
Distillation Precipitation Polymerization ◽  
Iron Oxide Magnetic Nanoparticles

Synthesis of phenylboronic acid functionalized iron oxide nanoparticles for glycoprotein enrichment via distillation–precipitation polymerization combined with thiol–yne click chemistry.

TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

2018 ◽  
Vol 6 (10) ◽  
Author(s):  
Hosam Zaghloul ◽  
Doaa A. Shahin ◽  
Ibrahim El- Dosoky ◽  
Mahmoud E. El-awady ◽  
Fardous F. El-Senduny ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cellular Uptake ◽  
Superparamagnetic Iron Oxide ◽  
Cyclin B1 ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mcf7 Cells ◽  
M Phase ◽  
The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

Sign in / Sign up

Export Citation Format

Share Document