Interfacial Diels–Alder Reaction between Furan-Functionalized Polymer Coatings and Maleimide-Terminated Poly(ethylene glycol)

2019 ◽  
Vol 123 (7) ◽  
pp. 4125-4132 ◽  
Author(s):  
Madeline Vauthier ◽  
Loïc Jierry ◽  
Miguel L. Martinez Mendez ◽  
Yann-Matthieu Durst ◽  
Julien Kelber ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Polymer Coatings ◽  
Alder Reaction ◽  
Diels Alder ◽  
Poly Ethylene Glycol ◽  
Diels Alder Reaction ◽  
Poly Ethylene

Best of both worlds: Diels–Alder chemistry towards fabrication of redox-responsive degradable hydrogels for protein release

RSC Advances ◽  
2016 ◽  
Vol 6 (78) ◽  
pp. 74757-74764 ◽  
Author(s):  
Ismail Altinbasak ◽  
Rana Sanyal ◽  
Amitav Sanyal
Keyword(s):  
Ethylene Glycol ◽  
Alder Reaction ◽  
Diels Alder ◽  
Protein Release ◽  
Poly Ethylene Glycol ◽  
Diels Alder Reaction ◽  
Redox Responsive ◽  
Poly Ethylene ◽  
Responsive Hydrogels

Poly(ethylene glycol)-based redox-responsive hydrogels have been preparedviathe Diels–Alder reaction between a furan-containing hydrophilic copolymer and a disulfide-containing bis-maleimide based crosslinker.

scholarly journals SYNTHESIS OF CHITOSAN-O-POLY(ETHYLENE GLYCOL) THROUGH DIELS-ALDER REACTION

2013 ◽  
Vol 013 (7) ◽  
pp. 903-908
Author(s):  
Jin Yu-cun ◽  
Lu Yi ◽  
Yu Lin ◽  
Cao Mo-yuan ◽  
Xiong Han ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Alder Reaction ◽  
Diels Alder ◽  
Poly Ethylene Glycol ◽  
Diels Alder Reaction ◽  
Poly Ethylene

Fabrication of Supramolecular Structured Hydrogels Based on Diels-Alder Click Reaction

2012 ◽  
Vol 562-564 ◽  
pp. 405-408 ◽  
Author(s):  
Hong Liang Wei ◽  
Ya Li Feng ◽  
Hui Juan Chu ◽  
Kai Yao
Keyword(s):  
Self Assembly ◽  
Click Reaction ◽  
Coupling Reaction ◽  
Alder Reaction ◽  
Diels Alder ◽  
Hydroxyethyl Methacrylate ◽  
Poly Ethylene Glycol ◽  
Diels Alder Reaction ◽  
Poly Ethylene ◽  
Reaction In Water

A novel kind of supramolecular structrued hydrogels were fabricated by Diels-Alder click reaction between furan-functionalized polypseudorotaxanes and polymeric dienophiles. Firstly, polypseudorotaxanes were prepared by supramolecular self-assembly of furan-terminated poly(ethylene glycol)(PEG) and α-cyclodextrins (CDs) in water. And polymeric dienophiles were synthesized by a coupling reaction between copolymer of hydroxyethyl methacrylate and N,N-dimethyl acrylamide and N-maleoyl alanine (AMI). The supramolecular structured hydrogels were prepared by Diels-Alder reaction in water.

Hydrogels with multiple clickable anchor points: synthesis and characterization of poly(furfuryl glycidyl ether)-block-poly(ethylene glycol) macromonomers

2019 ◽  
Vol 10 (32) ◽  
pp. 4485-4494 ◽  
Author(s):  
Karishma K. Adatia ◽  
Silke Keller ◽  
Tobias Götz ◽  
Günter E. M. Tovar ◽  
Alexander Southan
Keyword(s):  
Ethylene Glycol ◽  
Glycidyl Ether ◽  
Diels Alder ◽  
Synthesis And Characterization ◽  
Poly Ethylene Glycol ◽  
Polyacrylamide Hydrogels ◽  
Anchor Points ◽  
Poly Ethylene

Functional polyacrylamide hydrogels containing multiple furfuryl anchor points for Diels–Alder reactions were prepared employing new macromonomers.

A bioactive hyaluronic acid–based hydrogel cross-linked by Diels–Alder reaction for promoting neurite outgrowth of PC12 cells

2017 ◽  
Vol 32 (4) ◽  
pp. 382-396 ◽  
Author(s):  
Dongming Xing ◽  
Lie Ma ◽  
Changyou Gao
Keyword(s):  
Hyaluronic Acid ◽  
Ethylene Glycol ◽  
Neurite Outgrowth ◽  
Pc12 Cells ◽  
Alder Reaction ◽  
Poly Ethylene Glycol ◽  
Substitution Degree ◽  
Poly Ethylene

In order to improve neurite outgrowth on the in situ formed hyaluronic acid–based hydrogel, furan and methacrylate groups were grafted on hyaluronic acid successively. Furthermore, a laminin-derived peptide CQAASIKVAV was covalently immobilized via the Michael addition. The furan- and peptide-modified hyaluronic acid was then cross-linked in situ by mixing with bismaleimide poly(ethylene glycol) at 37 °C to obtain a bioactive hyaluronic acid–based hydrogel. The hyaluronic acid derivatives were characterized by 1H NMR and Fourier transform infrared spectroscopy. The gelation, swelling, and mechanical property of the hydrogels were analyzed. The modulus of the hydrogel could be tuned by changing furan substitution degree, while the peptide concentration could be changed by the ratio of furan- and peptide-modified hyaluronic acid with hyaluronic acid–furan. In vitro culture of PC12 cells showed that the longest neurite outgrowth appeared on the hyaluronic acid–poly(ethylene glycol) hydrogel with the highest peptide content (the substitution degree of peptide in furan- and peptide-modified hyaluronic acid was 23 %) and a lower threshold modulus of 4.5 kPa. The furan and methacrylate-functionalized hyaluronic acid provides a versatile platform for diverse functionalization and can be used for modulation of other cell behaviors as well.

scholarly journals Macrophage response to staphylococcal biofilms on crosslinked poly(ethylene) glycol polymer coatings and common biomaterials in vitro

2011 ◽  
Vol 21 ◽  
pp. 73-79 ◽  
Author(s):  
IC Saldarriaga Fernández ◽  
◽  
JF Da Silva Domingues ◽  
TG van Kooten ◽  
S Metzger ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Polymer Coatings ◽  
Poly Ethylene Glycol ◽  
Macrophage Response ◽  
Poly Ethylene
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