Tunable High Aspect Ratio Iron Oxide Nanorods for Enhanced Hyperthermia

2016 ◽  
Vol 120 (18) ◽  
pp. 10086-10093 ◽  
Author(s):  
Raja Das ◽  
Javier Alonso ◽  
Zohreh Nemati Porshokouh ◽  
Vijaysankar Kalappattil ◽  
David Torres ◽  
...  
2017 ◽  
Vol 71 ◽  
pp. 1342-1346 ◽  
Author(s):  
Ivo Safarik ◽  
Ralitsa Angelova ◽  
Eva Baldikova ◽  
Kristyna Pospiskova ◽  
Mirka Safarikova

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246124
Author(s):  
Oladunni B. Adeyiga ◽  
Coleman Murray ◽  
Hector E. Muñoz ◽  
Alberto Escobar ◽  
Dino Di Carlo

Magnetic ratcheting cytometry is a promising approach to separate magnetically-labeled cells and magnetic particles based on the quantity of magnetic material. We have previously reported on the ability of this technique to separate magnetically-labeled cells. Here, with a new chip design, containing high aspect ratio permalloy micropillar arrays, we demonstrate the ability of this technique to rapidly concentrate and collect superparamagnetic iron oxide particles. The platform consists of a mechatronic wheel used to generate and control a cycling external magnetic field that impinges on a “ratcheting chip.” The ratcheting chip is created by electroplating a 2D array of high aspect ratio permalloy micropillars onto a glass slide, which is embedded in a thin polymer layer to create a planar surface above the micropillars. By varying magnetic field frequency and direction through wheel rotation rate and angle, we direct particle movement on chip. We explore the operating conditions for this system, identifying the effects of varying ratcheting frequency, along with time, on the dynamics and resulting concentration of these magnetic particles. We also demonstrate the ability of the system to rapidly direct the movement of superparamagnetic iron oxide particles of varying sizes. Using this technique, 2.8 μm, 500 nm, and 100 nm diameter superparamagnetic iron oxide particles, suspended within an aqueous fluid, were concentrated. We further define the ability of the system to concentrate 2.8 μm superparamagnetic iron oxide particles, present in a liquid suspension, into a small chip surface area footprint, achieving a 100-fold surface area concentration, and achieving a concentration factor greater than 200%. The achieved concentration factor of greater than 200% could be greatly increased by reducing the amount of liquid extracted at the chip outlet, which would increase the ability of achieving highly sensitive downstream analytical techniques. Magnetic ratcheting-based enrichment may be useful in isolating and concentrating subsets of magnetically-labeled cells for diagnostic automation.


2014 ◽  
Vol 211 (8) ◽  
pp. 1889-1894 ◽  
Author(s):  
Syed Atif Pervez ◽  
Doohun Kim ◽  
Umer Farooq ◽  
Adnan Yaqub ◽  
Jeong-Hee Choi ◽  
...  

2007 ◽  
Vol 345-346 ◽  
pp. 1601-1604 ◽  
Author(s):  
M. Suhafri ◽  
Iskandar Idris Yaacob

High aspect ratios maghemite of iron oxide nanoparticles were prepared using water in oil microemulsions. A four component microemulsion system with cationic HTAB, n-butanol, noctane, and salt solution was used. Precipitations of iron oxide were initiated by mixing a microemulsion system containing Fe2+ with another microemulsion system containing OH-. The resulting particles were characterized using XRD, AGM and TEM. The XRD result showed the formation of maghemite. TEM showed that the average length of needle shaped particles increased from 28 nm up to 42 nm as the aging time was increased from 4 to 24 hours while the average diameter spherical particle remained at around 8 nm. The AGM confirmed that the particles are superparamagnetic.


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