The Key Gold: Enhanced Platinum Catalysis for the Selective Hydrogenation of α,β-Unsaturated Ketone

2016 ◽  
Vol 120 (23) ◽  
pp. 12446-12451 ◽  
Author(s):  
Yajie Xu ◽  
Lingli Liu ◽  
Hanbao Chong ◽  
Sha Yang ◽  
Ji Xiang ◽  
...  
Keyword(s):  
Selective Hydrogenation ◽  
Unsaturated Ketone ◽  
Platinum Catalysis

Deactivation of Pd/SiO2 catalyst in the continuous liquid-phase selective hydrogenation of an unsaturated ketone

2015 ◽  
Vol 116 (2) ◽  
pp. 451-466
Author(s):  
Dahao Jiang ◽  
Jun Mao ◽  
Zheng Fang ◽  
Jun Ni ◽  
Qunfeng Zhang ◽  
...  
Keyword(s):  
Liquid Phase ◽  
Selective Hydrogenation ◽  
Unsaturated Ketone

Synthesis of Some New Tetracyclic Pyrimidine Derivatives Using Exocyclic α,β-Unsaturated Ketone and Evaluation of Their Antitumor Activities

2016 ◽  
Vol 12 (8) ◽  
pp. 311-317
Author(s):  
Kamelia El-Mahdy
Keyword(s):  
Antitumor Activity ◽  
Spectroscopic Data ◽  
Acid Hydrazide ◽  
Chloroacetic Acid ◽  
Equimolar Amount ◽  
Unsaturated Ketone ◽  
Cyanoacetic Acid ◽  
Antitumor Activities ◽  
Pyrimidine Derivatives ◽  
Cyanoacetic Acid Hydrazide

Thiazolopyrimidine 2 was obtained from the reaction of dihydropyrimidinone with chloroacetic acid and benzaldehyde. Thiazolopyrimidine 2 containing an α,β-unsaturated ketonic function [-CH=CH-CO-] has been used as a component of Michael addition with an equimolar amount of dinucleophiles to give a series of novel tetracyclic pyrimidine derivatives. Treatment of thiazolopyrimidine 2 with uracil, aminotriazole, cyanoacetic acid hydrazide, o-phenylenediamine or diaminopyridine afforded the corresponding pyridopyrimidine, triazolopyrimidine, pyrazolone, benzodiazepine and triazepine derivative, respectively. The detailed synthesis, spectroscopic data, and antitumor activity for synthesized compounds were reported.

Cupin Variants as Macromolecular Ligand Library for Stereoselective Michael Addition of Nitroalkanes

2019 ◽  
Author(s):  
Nobutaka Fujieda ◽  
Miho Yuasa ◽  
Yosuke Nishikawa ◽  
Genji Kurisu ◽  
Shinobu Itoh ◽  
...  
Keyword(s):  
Michael Addition ◽  
In Silico ◽  
Addition Reaction ◽  
Single Point ◽  
Point Mutations ◽  
Unsaturated Ketone ◽  
Michael Addition Reaction ◽  
Beta Barrel ◽  
Cupin Superfamily ◽  
Single Point Mutations

Cupin superfamily proteins (TM1459) work as a macromolecular ligand framework with a double-stranded beta-barrel structure ligating to a Cu ion through histidine side chains. Variegating the first coordination sphere of TM1459 revealed that H52A and H54A/H58A mutants effectively catalyzed the diastereo- and enantio-selective Michael addition reaction of nitroalkanes to an α,β-unsaturated ketone. Moreover, in silico substrate docking signified C106N and F104W single-point mutations, which inverted the diastereoselectivity of H52A and further improved the stereoselectivity of H54A/H58A, respectively.

Selective Hydrogenation of Benzene to Cyclohexene over Ru-Zn Catalyst with Nanosized Zirconia as Dispersant

2010 ◽  
Vol 31 (2) ◽  
pp. 150-152
Author(s):  
Zhongyi LIU ◽  
Haijie SUN ◽  
Dongbin WANG ◽  
Wei GUO ◽  
Xiaoli ZHOU ◽  
...  
Keyword(s):  
Selective Hydrogenation

Selective Hydrogenation of Crotonaldehyde over Pt/Ce0.8La0.2O1.9 Catalysts

2011 ◽  
Vol 32 (3) ◽  
pp. 513-519
Author(s):  
Ping CHEN ◽  
Guanqun XIE ◽  
Haiying ZHENG ◽  
Lin ZHU ◽  
Mengfei LUO
Keyword(s):  
Selective Hydrogenation
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