Two Mechanisms of Fluorescence Intermittency in Single Core/Shell Quantum Dot

2015 ◽  
Vol 119 (39) ◽  
pp. 22646-22652 ◽  
Author(s):  
Igor S. Osad’ko ◽  
Ivan Yu. Eremchev ◽  
Andrei V. Naumov
Keyword(s):  
Quantum Dot ◽  
Core Shell ◽  
Fluorescence Intermittency

scholarly journals CdSe/ZnS Core-Shell-Type Quantum Dot Nanoparticles Disrupt the Cellular Homeostasis in Cellular Blood–Brain Barrier Models

2021 ◽  
Vol 22 (3) ◽  
pp. 1068
Author(s):  
Katarzyna Dominika Kania ◽  
Waldemar Wagner ◽  
Łukasz Pułaski
Keyword(s):  
Gene Expression ◽  
Quantum Dot ◽  
Blood Brain Barrier ◽  
Protein Gene ◽  
Brain Barrier ◽  
Core Shell ◽  
Cellular Homeostasis ◽  
Blood Brain ◽  
Shell Type ◽  
The Impact

Two immortalized brain microvascular endothelial cell lines (hCMEC/D3 and RBE4, of human and rat origin, respectively) were applied as an in vitro model of cellular elements of the blood–brain barrier in a nanotoxicological study. We evaluated the impact of CdSe/ZnS core-shell-type quantum dot nanoparticles on cellular homeostasis, using gold nanoparticles as a largely bioorthogonal control. While the investigated nanoparticles had surprisingly negligible acute cytotoxicity in the evaluated models, a multi-faceted study of barrier-related phenotypes and cell condition revealed a complex pattern of homeostasis disruption. Interestingly, some features of the paracellular barrier phenotype (transendothelial electrical resistance, tight junction protein gene expression) were improved by exposure to nanoparticles in a potential hormetic mechanism. However, mitochondrial potential and antioxidant defences largely collapsed under these conditions, paralleled by a strong pro-apoptotic shift in a significant proportion of cells (evidenced by apoptotic protein gene expression, chromosomal DNA fragmentation, and membrane phosphatidylserine exposure). Taken together, our results suggest a reactive oxygen species-mediated cellular mechanism of blood–brain barrier damage by quantum dots, which may be toxicologically significant in the face of increasing human exposure to this type of nanoparticles, both intended (in medical applications) and more often unintended (from consumer goods-derived environmental pollution).

scholarly journals Reversible Electrochemical Control over Photoexcited Luminescence of Core/Shell CdSe/ZnS Quantum Dot Film

2017 ◽  
Vol 12 (1) ◽  
Author(s):  
Bo Li ◽  
Meilin Lu ◽  
Weilong Liu ◽  
Xiaojun Zhu ◽  
Xing He ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Core Shell ◽  
Electrochemical Control

scholarly journals Quantum funneling in blended multi-band gap core/shell colloidal quantum dot solar cells

2015 ◽  
Vol 107 (10) ◽  
pp. 103902 ◽  
Author(s):  
Darren C. J. Neo ◽  
Samuel D. Stranks ◽  
Giles E. Eperon ◽  
Henry J. Snaith ◽  
Hazel E. Assender ◽  
...  
Keyword(s):  
Solar Cells ◽  
Quantum Dot ◽  
Band Gap ◽  
Core Shell ◽  
Quantum Dot Solar Cells ◽  
Colloidal Quantum Dot ◽  
Multi Band

Fabrication and dual imaging properties of quantum dot/silica core-shell particles immobilized with gold nanoparticles

2018 ◽  
Vol 33 (11) ◽  
pp. 737-747
Author(s):  
Ting-ting Li ◽  
Tomoya Inose ◽  
Takahiro Oikawa ◽  
Masayuki Tokunaga ◽  
Keiichiro Hatoyama ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Quantum Dot ◽  
Core Shell ◽  
Silica Core ◽  
Dual Imaging ◽  
Shell Particles ◽  
Imaging Properties
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