TEM Structure, Nanomechanical Property, and Adhesive Force of Magnetron-Sputtered Cr-DLC Coating on a Nitrided Ti6Al4V Alloy

2021 ◽  
Author(s):  
Kong Weicheng ◽  
Li Kangmei ◽  
Hu Jun
Keyword(s):  
Adhesive Force ◽  
Ti6al4v Alloy ◽  
Nanomechanical Property ◽  
Dlc Coating

Nanorobots Sense Local Physiochemical Heterogeneities of Tumor Matrisome

2020 ◽  
Author(s):  
Debayan Dasgupta ◽  
Dharma Pally ◽  
Deepak K. Saini ◽  
Ramray Bhat ◽  
Ambarish Ghosh
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Adhesive Force ◽  
Surrounding Tissue ◽  
Quantitative Measurements ◽  
Malignant Breast Tumor ◽  
Malignant Breast ◽  
Cancer Dissemination

The dissemination of cancer is brought about by continuous interaction of malignant cells with their surrounding tissue microenvironment. Understanding and quantifying the remodeling of local extracellular matrix (ECM) by invading cells can therefore provide fundamental insights into the dynamics of cancer dissemination. In this paper, we use an active and untethered nanomechanical tool, realized as magnetically driven nanorobots, to locally probe a 3D tissue culture microenvironment consisting of cancerous and non-cancerous epithelia, embedded within reconstituted basement membrane (rBM) matrix. Our assay is designed to mimic the in vivo histopathological milieu of a malignant breast tumor. We find that nanorobots preferentially adhere to the ECM near cancer cells: this is due to the distinct charge conditions of the cancer-remodeled ECM. Surprisingly, quantitative measurements estimate that the adhesive force increases with the metastatic ability of cancer cell lines, while the spatial extent of the remodeled ECM was measured to be approximately 40 μm for all cancer cell lines studied here. We hypothesized and experimentally confirmed that specific sialic acid linkages specific to cancer-secreted ECM may be a major contributing factor in determining this adhesive behavior. The findings reported here can lead to promising applications in cancer diagnosis, quantification of cancer aggression, in vivo drug delivery applications, and establishes the tremendous potential of magnetic nanorobots for fundamental studies of cancer biomechanics.

Oxide-Scale and α-Casing Characterization in Ti6Al4V Alloy Oxidised in Oxygen Gas

2006 ◽  
Vol 43 (11) ◽  
pp. 559-574
Author(s):  
M. N. Mungole ◽  
M. Surender ◽  
S. Bhargava
Keyword(s):  
Oxide Scale ◽  
Ti6al4v Alloy ◽  
Oxygen Gas

Structure and tribocorrosion properties of duplex treatment coatings of TiSiCN/nitride on Ti6Al4V alloy

2019 ◽  
Vol 45 (9) ◽  
pp. 12461-12468 ◽  
Author(s):  
Minpeng Dong ◽  
Yebiao Zhu ◽  
Chunting Wang ◽  
Lei Shan ◽  
Jinlong Li
Keyword(s):  
Ti6al4v Alloy ◽  
Duplex Treatment

Characterization of UHMWPE- HAp coating produced by dip coating method on Ti6Al4V alloy

2021 ◽  
pp. 127091
Author(s):  
Gözde Çelebi Efe ◽  
Elif Yenilmez ◽  
İbrahim Altinsoy ◽  
Serbülent Türk ◽  
Cuma Bindal
Keyword(s):  
Dip Coating ◽  
Ti6al4v Alloy ◽  
Coating Method ◽  
Dip Coating Method

Hot corrosion damage mechanism of Ti6Al4V alloy in marine environment

Vacuum ◽  
2021 ◽  
pp. 110350
Author(s):  
Hulin Wu ◽  
Ping Gong ◽  
Suying Hu ◽  
Lin Xiang ◽  
Enlei Wang ◽  
...  
Keyword(s):  
Marine Environment ◽  
Hot Corrosion ◽  
Corrosion Damage ◽  
Damage Mechanism ◽  
Ti6al4v Alloy

scholarly journals Multi-Characteristics Optimization in Micro-milling of Ti6Al4V Alloy

2021 ◽  
Vol 1950 (1) ◽  
pp. 012046
Author(s):  
Ashutosh Roushan ◽  
U. Srinivas Rao ◽  
Karali Patra ◽  
Priyabrata Sahoo
Keyword(s):  
Ti6al4v Alloy ◽  
Micro Milling
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