Perfluorinated Phthalocyanines on Cu(110) and Cu(110)-(2 × 1)O: The Special Role of the Central Cobalt Atom

2021 ◽  
Vol 125 (16) ◽  
pp. 8803-8814
Author(s):  
Axel Belser ◽  
Katharina Greulich ◽  
Peter Grüninger ◽  
Reimer Karstens ◽  
Ruslan Ovsyannikov ◽  
...  
Keyword(s):  
Cobalt Atom ◽  
Special Role

Development of Social and Economic Forecasting and Ideas of A. Anchishkin

2013 ◽  
pp. 143-155
Author(s):  
A. Klepach ◽  
G. Kuranov
Keyword(s):  
Economic Planning ◽  
Special Role ◽  
Economic Management ◽  
Economic Forecasting ◽  
Russian Economy ◽  
World Economic ◽  
Long Term Forecasting ◽  
Working Out

The role of the prominent Soviet economist, academician A. Anchishkin (1933—1987), whose 80th birth anniversary we celebrate this year, in the development of ideas and formation of economic forecasting in the country at the time when the directive planning acted as a leading tool of economic management is explored in the article. Besides, Anchishkin’s special role is noted in developing a comprehensive program of scientific and technical progress, an information basis for working out long-term forecasts of the country’s development, moreover, his contribution to the creation of long-term forecasting methodology and improvement of the statistical basis for economic analysis and economic planning. The authors show that social and economic forecasting in the period after 1991, which has undertaken a number of functions of economic planning, has largely relied on further development of Anchishkin’s ideas, at the same time responding to new challenges for the Russian economy development during its entry into the world economic system.

METHODOLOGY OF PLAYING ACTIVITY IN REHABILITATION PRACTICE

2018 ◽  
Vol 28 (7) ◽  
pp. 2543-2548
Author(s):  
Petya Kasnakova
Keyword(s):  
Positive Emotions ◽  
Healing Process ◽  
Disease Process ◽  
Special Role ◽  
Thought Processes ◽  
Active Involvement ◽  
Movement Skills ◽  
Movement Training ◽  
Motor Movement

The games play a special role in rehabilitation practice. The positive emotions they cause in patients cannot be achieved by other methods and means of modern rehabilitation. The role of game playing activity in practice is crucial to the achievement of one of the important tasks in implementing rehabilitation measures, namely to evacuate the patient from the depressed mental state, to distract him from the disease process and to focus on mobilizing his healing powers. The mood, the emotional charge and the dynamics that the games create are particularly suited to awakening the patient's interest in the healing process, their attraction and their active involvement in the rehabilitation activities. The connection between the actions in the game and the movements in the analytical exercises accelerates the formation of motor habits, physical qualities and skills not only in children but also in adult patients with various pathological injuries. Rehabilitation games are suitable for all ages by enhancing the health of the occupants, developing their mental qualities, improving the activity of the vestibular, visual and motor analyzers. The basis of the motor movement training game methodology and the improvement of motor movement skills is the activation of the thought processes and emotional experiences, the development of the functions of the musculoskeletal system, the cardiovascular system and the respiratory system.

РОЛЬ КНИГИ В ВОСПИТАНИИ ПОЛИКУЛЬТУРНОЙ ЛИЧНОСТИ

2020 ◽  
pp. 58-60
Author(s):  
Замира Сейткожоева
Keyword(s):  
Computer Games ◽  
Human Life ◽  
Interpersonal Relationship ◽  
Special Role ◽  
Multicultural Personality ◽  
Younger Age ◽  
Bibliographic Data ◽  
Life Education ◽  
Different Cultures

Аннотация: В статье обращено внимание на исключительную роль книги в жизни человека, воспитание молодежи. Книга сопровождает человека всю жизнь. Однако в последние годы замечается снижение интереса к чтению книг. Отдается предпочтение компьютеру, играм, телевизору, слушанию музыки через наушники. Во избежание деградации личности, в воспитании грамотной, гуманной, толерантной личности необходимо приучать подрастающее поколение к вдумчивому чтению книг. Значительное место в развитии личности занимает внеклассное чтение, к которому нужно прививать интерес еще во время учебы в младшем возрасте. В мире особая роль принадлежит межличностным отношениям, формированию такой личности, которая могла бы жить в согласии с носителями разных культур. Для формирования поликультурной личности важная роль принадлежит культурному наследию, основу которого составляют книги. Ключевые слова: роль книги, гуманная личность, толерантная личность, библиографические материалы, указатели библиографических данных, справочная литература, поликультурная личность, внеклассное чтение, информатизация, интерес к чтению. Аннотация: Макалада адамдын жашоосундагы жаштарды тарбиялоодогу китептин өзгөчө мааниси, ролуна өзгөчө көңүл бурулган. Бир эле мезгилде, соңку жылдарда китептерибизге болгон адамдардын кызыгууларды төмөндөп бараткандыгы байкалган.Учурда поли- же ар кандай оюндарга, телевизор көрүүгө, кулакчын аркылуу модалуу музыка угууга, артыкчылык берилип жатат. Билимдүү, гумандуу толеранттуу инсанды тарбиялап чыгууга да, анын деградацияга кабылышынан сактап калыш үчүн, өсүп келе жаткан муундарды өзүнүн айкалыштыра алуусу менен китептерди берилип жана ой жүгүртүп алууга үйрөтүү- өтө зарыл талап болуп эсептелет. Инсандын онүгүндө окуудан тышкаркы окуунун маанилүү орду бар. Мындай окууга буга кызыгуусун өркүндөтүүнун башталгыч каласстардан тарта үйрөтүү абзел. Инсандар аралык байланыштар дүйнөдө өзгөчө орун ээлейт, алар башка маданий өкүлдөрү менен макулдуктулукта жашоого даяр. Полимаданиятту инсандын калыптанышына ар маданияттын мурасы өтө чоң ролду ойнойт, анын негизин китептер түзөт. Түйүндүү сөздөр: китептин мааниси жана ролу, гумандуу инсан, толеранттуу инсан, библиографиялык материалдар, библиографиялык маалыматтарды көрсөтүү сурантыла билүү адабияты, полимаданиятуу инсан, окуудан тышкаркы окуу,маалымдуулук, окууга кызыгуу The article draws attention to the exceptional role of the book in human life, education of young people. The book accompanies a person all his life. However, in recent years, there has been a decline in interest in reading books. Preference is given to a computer, games, TV, listening to music through headphones. In order to avoid degradation of the personality, it is necessary to accustom the younger generation to thoughtful reading of books. a significant place in the development of personality takes extracurricular reading, to which you need to instill interest even while studying at a younger age. In the world a special role belongs to interpersonal relationship, the formation of such a personality, who could live in harmony with speakers of different cultures. To form a multicultural personality an important role belongs to cultural heritage, the basis of which are books Keywords: the role of the book, humane personality, tolerant personality, bibliographic materials, indexes of bibliographic data, reference literature, multicultural personality, extracurricular reading, informatization, interest in reading.

Diet and Nutritional Interventions with the Special Role of Myo-Inositol in Gestational Diabetes Mellitus Management. An Evidence-Based Critical Appraisal

2019 ◽  
Vol 25 (22) ◽  
pp. 2467-2473 ◽  
Author(s):  
Enrique Reyes-Muñoz ◽  
Federica Di Guardo ◽  
Michal Ciebiera ◽  
Ilker Kahramanoglu ◽  
Thozhukat Sathyapalan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Metabolic Diseases ◽  
Nutritional Intervention ◽  
Attractive Alternative ◽  
Special Role ◽  
Dose Frequency ◽  
Nutritional Interventions

Background: Gestational Diabetes Mellitus (GDM), defined as glucose intolerance with onset or first recognition during pregnancy, represents one of the most common maternal-fetal complications during pregnancy and it is associated with poor perinatal outcomes. To date, GDM is a rising condition over the last decades coinciding with the ongoing epidemic of obesity and Type 2 Diabetes Mellitus (T2DM). Objective: The aim of this review is to discuss the role of diet and nutritional interventions in preventing GDM with the explanation of the special role of myo-inositol (MI) in this matter. Methods: We performed an overview of the most recent literature data on the subject with particular attention to the effectiveness of diet and nutritional interventions in the prevention of GDM with the special role of MI. Results: Nutritional intervention and physical activity before and during pregnancy are mandatory in women affected by GDM. Moreover, the availability of insulin-sensitizers such as different forms of inositol has dramatically changed the scenario, allowing the treatment of several metabolic diseases, such as those related to glucose dysbalance. Although the optimal dose, frequency, and form of MI administration need to be further investigated, diet supplementation with MI appears to be an attractive alternative for the GDM prevention as well as for the reduction of GDM-related complications. Conclusion: More studies should be conducted to prove the most effective nutritional intervention in GDM. Regarding the potential effectiveness of MI, further evidence in multicenter, randomized controlled trials is needed to draw firm conclusions.

The Role of Lipids and Membranes in the Pathogenesis of Alzheimer's Disease: A Comprehensive View

2018 ◽  
Vol 15 (13) ◽  
pp. 1191-1212 ◽  
Author(s):  
Botond Penke ◽  
Gábor Paragi ◽  
János Gera ◽  
Róbert Berkecz ◽  
Zsolt Kovács ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Signaling Pathways ◽  
Membrane Lipids ◽  
Specific Protein ◽  
Dietary Factors ◽  
Lipid Signaling ◽  
Special Role ◽  
Aβ Peptides

Lipids participate in Amyloid Precursor Protein (APP) trafficking and processing - important factors in the initiation of Alzheimer’s disease (AD) pathogenesis and influence the formation of neurotoxic β-amyloid (Aβ) peptides. An important risk factor, the presence of ApoE4 protein in AD brain cells binds the lipids to AD. In addition, lipid signaling pathways have a crucial role in the cellular homeostasis and depend on specific protein-lipid interactions. The current review focuses on pathological alterations of membrane lipids (cholesterol, glycerophospholipids, sphingolipids) and lipid metabolism in AD and provides insight in the current understanding of biological membranes, their lipid structures and functions, as well as their role as potential therapeutic targets. Novel methods for studying the membrane structure and lipid composition will be reviewed in a broad sense whereas the use of lipid biomarkers for early diagnosis of AD will be shortly summarized. Interactions of Aβ peptides with the cell membrane and different subcellular organelles are reviewed. Next, the details of the most important lipid signaling pathways, including the role of the plasma membrane as stress sensor and its therapeutic applications are given. 4-hydroxy-2-nonenal may play a special role in the initiation of the pathogenesis of AD and thus the “calpain-cathepsin hypothesis” of AD is highlighted. Finally, the most important lipid dietary factors and their possible use and efficacy in the prevention of AD are discussed.

The N-pattern

2018 ◽  
Author(s):  
Martin Maiden
Keyword(s):  
Special Role ◽  
Third Person ◽  
Verb Meaning

The chapter presents the role of stress and stress-related vocalic differentiation in creating a pattern of root allomorphy (the N-pattern), which distinguishes the singular and third-person forms of the present indicative and subjunctive, and of the imperative, from the rest of the paradigm. It is shown how numerous innovatory patterns (including suppletion, defectiveness, heteroclisis, and periphrases) replicate this pattern in diachrony. The possible role of markedness or of residual phonological conditioning is critically considered. It is suggested that the verb meaning ‘go’ may have played a special role. The independence of the N-pattern from extramorphological conditioning is reaffirmed.

scholarly journals Afro-Communitarianism and the Role of Traditional African Healers in the COVID-19 Pandemic

2021 ◽  
Author(s):  
Luís Cordeiro-Rodrigues ◽  
Thaddeus Metz
Keyword(s):  
Cultural Capital ◽  
Cultural Context ◽  
Preventive Measures ◽  
Healthcare Systems ◽  
Traditional Healers ◽  
Local Communities ◽  
Special Role ◽  
Ethical Perspective ◽  
The Face

Abstract The COVID-19 pandemic has brought significant challenges to healthcare systems worldwide, and in Africa, given the lack of resources, they are likely to be even more acute. The usefulness of Traditional African Healers in helping to mitigate the effects of pandemic has been neglected. We argue from an ethical perspective that these healers can and should have an important role in informing and guiding local communities in Africa on how to prevent the spread of COVID-19. Particularly, we argue not only that much of the philosophy underlying Traditional African Medicine is adequate and compatible with preventive measures for COVID-19, but also that Traditional African Healers have some unique cultural capital for influencing and enforcing such preventive measures. The paper therefore suggests that not only given the cultural context of Africa where Traditional African Healers have a special role, but also because of the normative strength of the Afro-communitarian philosophy that informs it, there are good ethical reasons to endorse policies that involve Traditional Healers in the fight against COVID-19. We also maintain that concerns about Traditional African Healers objectionably violating patient confidentiality or being paternalistic are much weaker in the face of COVID-19.

scholarly journals The Potential Role of Exosomes in Child and Adolescent Obesity

Children ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 196
Author(s):  
Ioanna Maligianni ◽  
Christos Yapijakis ◽  
Flora Bacopoulou ◽  
George Chrousos
Keyword(s):  
Child And Adolescent ◽  
Cardiovascular Complications ◽  
Adolescent Obesity ◽  
Overweight And Obesity ◽  
Calorie Intake ◽  
Target Cells ◽  
Special Role ◽  
Exosomal Mirnas ◽  
Risk Biomarkers

Child and adolescent obesity constitute one of the greatest contemporary public health menaces. The enduring disproportion between calorie intake and energy consumption, determined by a complex interaction of genetic, epigenetic, and environmental factors, finally leads to the development of overweight and obesity. Child and adolescent overweight/obesity promotes smoldering systemic inflammation (“para-inflammation”) and increases the likelihood of later metabolic and cardiovascular complications, including metabolic syndrome and its components, which progressively deteriorate during adulthood. Exosomes are endosome-derived extracellular vesicles that are secreted by a variety of cells, are naturally taken-up by target cells, and may be involved in many physiological and pathological processes. Over the last decade, intensive research has been conducted regarding the special role of exosomes and the non-coding (nc) RNAs they contain (primarily micro (mi) RNAs, long (l) non-coding RNAs, messenger (m) RNAs and other molecules) in inter-cellular communications. Through their action as communication mediators, exosomes may contribute to the pathogenesis of obesity and associated disorders. There is increasing evidence that exosomal miRNAs and lncRNAs are involved in pivotal processes of adipocyte biology and that, possibly, play important roles in gene regulation linked to human obesity. This review aims to improve our understanding of the roles of exosomes and their cargo in the development of obesity and related metabolic and inflammatory disorders. We examined their potential roles in adipose tissue physiology and reviewed the scarce data regarding the altered patterns of circulating miRNAs and lncRNAs observed in obese children and adolescents, compared them to the equivalent, more abundant existing findings of adult studies, and speculated on their proposed mechanisms of action. Exosomal miRNAs and lncRNAs could be applied as cardiometabolic risk biomarkers, useful in the early diagnosis and prevention of obesity. Furthermore, the targeting of crucial circulating exosomal cargo to tissues involved in the pathogenesis and maintenance of obesity could provide a novel therapeutic approach to this devastating and management-resistant pandemic.

scholarly journals Pancreatic ductal adenocarcinoma concomitant with pancreatic metastases of clear-cell renal cell carcinoma: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Lena Haeberle ◽  
Melanie Busch ◽  
Julian Kirchner ◽  
Georg Fluegen ◽  
Gerald Antoch ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Ductal Adenocarcinoma ◽  
Special Role ◽  
Cell Renal Cell Carcinoma ◽  
Pancreatic Metastases

Abstract Background Metastatic spread to the pancreas is a rare event. Renal cell carcinoma represents one possible site of origin of pancreatic metastases. Renal cell carcinoma often metastasizes late and exclusively to the pancreas, suggesting a special role of renal cell carcinoma among primaries metastasizing to the pancreas. Even rarer, renal cell carcinoma may occur simultaneously with pancreatic ductal adenocarcinoma. Case presentation We present the case of a 78-year-old male Caucasian patient with a history of clear-cell renal cell carcinoma treated with oncological left nephrectomy 20 years before. The patient was diagnosed with pancreatic ductal adenocarcinoma by fine-needle aspiration cytology. At our institution, he received neoadjuvant therapy with folic acid, fluorouracil, irinotecan, oxaliplatin for borderline-resectable pancreatic ductal adenocarcinoma, and subsequently underwent total pancreatectomy. Upon resection, pancreatic ductal adenocarcinoma as well as two metachronous metastases of clear-cell renal cell carcinoma occurring simultaneously and cospatially with pancreatic ductal adenocarcinoma were diagnosed in the pancreatic body. Conclusions Renal cell carcinoma metastases of the pancreas are rare and often occur decades after the initial diagnosis of renal cell carcinoma. The combination of renal cell carcinoma metastases and pancreatic ductal adenocarcinoma is even rarer. However, the possibility should be considered by clinicians, radiologists, and pathologists. The special role of renal cell carcinoma as a site of origin of pancreatic metastasis should be further elucidated.

Porcine glutathione transferase Alpha 2-2 is a human GST A3-3 analogue that catalyses steroid double-bond isomerization

2010 ◽  
Vol 431 (1) ◽  
pp. 159-167 ◽  
Author(s):  
Natalia Fedulova ◽  
Françoise Raffalli-Mathieu ◽  
Bengt Mannervik
Keyword(s):  
Double Bond ◽  
Glutathione Transferase ◽  
Biological Species ◽  
Glutathione Transferases ◽  
Special Role ◽  
Primary Role ◽  
The Novel ◽  
Protective Function ◽  
Isomerase Activity

A primary role of GSTs (glutathione transferases) is detoxication of electrophilic compounds. In addition to this protective function, hGST (human GST) A3-3, a member of the Alpha class of soluble GSTs, has prominent steroid double-bond isomerase activity. The isomerase reaction is an obligatory step in the biosynthesis of steroid hormones, indicating a special role of hGST A3-3 in steroidogenic tissues. An analogous GST with high steroid isomerase activity has so far not been found in any other biological species. In the present study, we characterized a Sus scrofa (pig) enzyme, pGST A2-2, displaying high steroid isomerase activity. High levels of pGST A2-2 expression were found in ovary, testis and liver. In its functional properties, other than steroid isomerization, pGST A2-2 was most similar to hGST A3-3. The properties of the novel porcine enzyme lend support to the notion that particular GSTs play an important role in steroidogenesis.

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