Synthesis of NaGdF4:Er3+/Yb3+ Upconversion Particles as Exogenous Contrast Agent for Swept-Source Optical Coherence Tomography: In Vitro Animal Tissue Imaging

2020 ◽  
Vol 124 (33) ◽  
pp. 18366-18378
Author(s):  
Sachin Kumar Maurya ◽  
Muktesh Mohan ◽  
Raju Poddar ◽  
Dulal Senapati ◽  
Shweta Singh ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Contrast Agent ◽  
Animal Tissue ◽  
Tissue Imaging ◽  
Optical Coherence ◽  
Swept Source ◽  
Exogenous Contrast Agent

scholarly journals Contrast Enhancement of Optical Coherence Tomography Images Using Branched Gold Nanoparticles

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Y. Ponce de León ◽  
J. L. Pichardo-Molina ◽  
N. Alcalá Ochoa ◽  
D. Luna-Moreno
Keyword(s):  
Gold Nanoparticles ◽  
Optical Coherence Tomography ◽  
Contrast Agent ◽  
Plasmon Resonance ◽  
Tissue Imaging ◽  
Optical Coherence ◽  
Tissue Phantoms ◽  
Promising Application ◽  
Oct Imaging ◽  
Scatter Light

We propose the use of branched gold nanoparticles (B-GNPs) as a contrast agent for optical coherence tomography (OCT) imaging. Our results show that even when the central source of our OCT (1325 nm) is too far from the maximum peak of the plasmon resonance, branched nanoparticles scatter light very efficiently at this wavelength. B-GNPs were tested as a contrast agent in water and agarose-TiO2tissue phantoms; the estimated increments in contrast were 9.19 dB and 15.07 dB for branched nanoparticles in water with concentrations of2.2×109 NPs/mL and6.6×109 NPs/mL, respectively, while for agarose-TiO2tissue phantoms the estimated value was 3.17 dB. These results show the promising application of B-GNPs as a contrast agent for tissue imaging using OCT, not only for sources at 1325 nm but also at other central wavelengths located between 800 and 1000 nm.

scholarly journals Assessment of Demineralization Inhibition Effects of Dentin Desensitizers Using Swept-Source Optical Coherence Tomography

Materials ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 1876
Author(s):  
Kumiko Matsuzaki ◽  
Yasushi Shimada ◽  
Yasuo Shinno ◽  
Serina Ono ◽  
Kozo Yamaji ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Silicate Glass ◽  
Signal Intensity ◽  
Chemical Elements ◽  
Region Of Interest ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
Morphological Differences

The purpose of this study was to evaluate the mechanism of action and the inhibiting effects of two types of desensitizers against dentin demineralization using pre-demineralized hypersensitivity tooth model in vitro. In this study, we confirmed that a hypersensitivity tooth model from our preliminary experiment could be prepared by immersing dentin discs in an acetic acid-based solution with pH 5.0 for three days. Dentin discs with three days of demineralization were prepared and applied by one of the desensitizers containing calcium fluoro-alumino-silicate glass (Nanoseal, NS) or fluoro-zinc-silicate glass (Caredyne Shield, CS), followed by an additional three days of demineralization. Dentin discs for three days of demineralization (de3) and six days of demineralization (de6) without the desensitizers were also prepared. The dentin discs after the experimental protocol were scanned using swept-source optical coherence tomography (SS-OCT) to image the cross-sectional (2D) view of the samples and evaluate the SS-OCT signal. The signal intensity profiles of SS-OCT from the region of interest of 300, 500, and 700 µm in depth were obtained to calculate the integrated signal intensity and signal attenuation coefficient. The morphological differences and remaining chemical elements of the dentin discs were also analyzed using scanning electron microscopy and energy-dispersive X-ray spectroscopy. SS-OCT images of CS and NS groups showed no obvious differences between the groups. However, SS-OCT signal profiles for both the CS and NS groups showed smaller attenuation coefficients and larger integrated signal intensities than those of the de6 group. Reactional deposits of the desensitizers even after the additional three days of demineralization were observed on the dentin surface in NS group, whereas remnants containing Zn were detected within the dentinal tubules in CS group. Consequently, both CS and NS groups showed inhibition effects against the additional three days of demineralization in this study. Our findings demonstrate that SS-OCT signal analysis can be used to monitor the dentin demineralization and inhibition effects of desensitizers against dentin demineralization in vitro.

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