Probing Early-Stage Aggregation of Low Molecular Weight Gelator in an Organic Solvent

2020 ◽  
Vol 124 (11) ◽  
pp. 2277-2288
Author(s):  
Md Masrul Huda ◽  
Neeraj Rai
Keyword(s):  
Molecular Weight ◽  
Organic Solvent ◽  
Early Stage ◽  
Low Molecular Weight ◽  
Low Molecular Weight Gelator

scholarly journals Holistic Metabolomic Laboratory-Developed Test (LDT): Development and Use for the Diagnosis of Early-Stage Parkinson’s Disease

Metabolites ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 14
Author(s):  
Petr G. Lokhov ◽  
Dmitry L. Maslov ◽  
Steven Lichtenberg ◽  
Oxana P. Trifonova ◽  
Elena E. Balashova
Keyword(s):  
Parkinson’S Disease ◽  
Molecular Weight ◽  
Parkinson's Disease ◽  
High Resolution Mass Spectrometry ◽  
Early Stage ◽  
Disease Diagnosis ◽  
The Body ◽  
Low Molecular Weight ◽  
Low Molecular Weight Compounds

A laboratory-developed test (LDT) is a type of in vitro diagnostic test that is developed and used within a single laboratory. The holistic metabolomic LDT integrating the currently available data on human metabolic pathways, changes in the concentrations of low-molecular-weight compounds in the human blood during diseases and other conditions, and their prevalent location in the body was developed. That is, the LDT uses all of the accumulated metabolic data relevant for disease diagnosis and high-resolution mass spectrometry with data processing by in-house software. In this study, the LDT was applied to diagnose early-stage Parkinson’s disease (PD), which currently lacks available laboratory tests. The use of the LDT for blood plasma samples confirmed its ability for such diagnostics with 73% accuracy. The diagnosis was based on relevant data, such as the detection of overrepresented metabolite sets associated with PD and other neurodegenerative diseases. Additionally, the ability of the LDT to detect normal composition of low-molecular-weight compounds in blood was demonstrated, thus providing a definition of healthy at the molecular level. This LDT approach as a screening tool can be used for the further widespread testing for other diseases, since ‘omics’ tests, to which the metabolomic LDT belongs, cover a variety of them.

Diaminomalenonitrile-decorated cholesterol-based supramolecular gelator: aggregation, multiple analyte (hydrazine, Hg2+ and Cu2+) detection and dye adsorption

2018 ◽  
Vol 42 (16) ◽  
pp. 13718-13725 ◽  
Author(s):  
Atanu Panja ◽  
Kumaresh Ghosh
Keyword(s):  
Molecular Weight ◽  
Functional Group ◽  
Dye Adsorption ◽  
Low Molecular Weight ◽  
Practical Applications ◽  
Supramolecular Gels ◽  
Low Molecular Weight Gelator

A low molecular weight gelator (LMWG) containing a diaminomalenonitrile functional group 1 forms supramolecular gels from DMF–H2O and 1,2-dichlorobenzene. The DMF/H2O gel is multi-analyte responsive (Hg2+, Cu2+ and hydrazine) with practical applications in dye adsorption from water.

Turning Around theL-Phe-D-Oxd Moiety for a Versatile Low-Molecular-Weight Gelator

2014 ◽  
Vol 2014 (27) ◽  
pp. 5954-5961 ◽  
Author(s):  
Lorenzo Milli ◽  
Nicola Castellucci ◽  
Claudia Tomasini
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Low Molecular Weight Gelator

Changes of the Polypeptide Composition in Thylakoid Membranes during Differentiation

1990 ◽  
Vol 45 (3-4) ◽  
pp. 253-257 ◽  
Author(s):  
Magdolna Droppa ◽  
Jiri Masojidek ◽  
Gábor Horváth
Keyword(s):  
Molecular Weight ◽  
Chloroplast Development ◽  
Early Stage ◽  
Relative Concentration ◽  
Thylakoid Membranes ◽  
Low Molecular Weight ◽  
Polypeptide Composition ◽  
Lhc Ii

Changes in membrane polypeptide composition during greening of etiolated maize were investigated to confirm the existence of the developmental polypeptides of 12 - 15 kDa described recently in virescent soybean mutant [M. Droppa, M. L. Ghirardi, G. Horváth, and A. Melis, Biochim. Biophys. Acta 932, 138 - 145 (1988)]. These low molecular weight polypeptides were the most abundant proteins at the early stage of greening, but were largely absent from fully developed thylakoids. During greening the relative concentration of the 12-15 kDa polypeptides were inversely proportional to that of LHC II, suggesting a role of these polypeptides in the assembly of the LHC II and/or chloroplast development.

Exploring the thermal reversibility and tunability of a low molecular weight gelator using vibrational and electronic spectroscopy and rheology

Soft Matter ◽  
2019 ◽  
Vol 15 (16) ◽  
pp. 3418-3431 ◽  
Author(s):  
David DiGuiseppi ◽  
Lavenia Thursch ◽  
Nicolas J. Alvarez ◽  
Reinhard Schweitzer-Stenner
Keyword(s):  
Molecular Weight ◽  
Self Assembly ◽  
Electronic Spectroscopy ◽  
Low Molecular Weight ◽  
Thermal Reversibility ◽  
Low Molecular Weight Gelator

The strength of metastable gels formed by self-assembly of GAG tripeptides in water can be tuned by annealing.

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