scholarly journals Complexation Kinetics of Cyclodextrins with Bile Salt Anions: Energy Barriers for the Threading of Ionic Groups

2019 ◽  
Vol 123 (46) ◽  
pp. 9831-9838 ◽  
Author(s):  
Christian Schönbeck
Keyword(s):  
Bile Salt ◽  
Energy Barriers ◽  
Ionic Groups ◽  
Kinetics Of ◽  
Complexation Kinetics

Complexation kinetics of highly substituted acyclic, monocyclic, and bicyclic tetraamines with copper(II) in basic aqueous media

1986 ◽  
Vol 25 (21) ◽  
pp. 3751-3757 ◽  
Author(s):  
Jane A. Drumhiller ◽  
Francois Montavon ◽  
Jean Marie Lehn ◽  
Richard W. Taylor
Keyword(s):  
Aqueous Media ◽  
Kinetics Of ◽  
Complexation Kinetics

Complexation Kinetics of Copper(II) and Nickel(II) with Macrocycles:  Identification of an Outer-Sphere Chelate Effect

2007 ◽  
Vol 46 (10) ◽  
pp. 4002-4009 ◽  
Author(s):  
Nichola McCann ◽  
Geoffrey A. Lawrance ◽  
Yorck-Michael Neuhold ◽  
Marcel Maeder
Keyword(s):  
Outer Sphere ◽  
Chelate Effect ◽  
Kinetics Of ◽  
Complexation Kinetics

Effect of adjuvant-induced systemic inflammation in rats on hepatic disposition kinetics of taurocholate

2011 ◽  
Vol 300 (1) ◽  
pp. G130-G136 ◽  
Author(s):  
Michael S. Roberts ◽  
Xin Liu ◽  
Yuhong Zou ◽  
Gerhard A. Siebert ◽  
Ping Chang ◽  
...  
Keyword(s):  
Bile Salt ◽  
Mrna Expression ◽  
Rate Constant ◽  
Systemic Inflammation ◽  
Atp Content ◽  
Influx Rate ◽  
Hepatic Disposition ◽  
Disposition Kinetics ◽  
Bile Salt Transporters ◽  
Kinetics Of

It has been reported that the adjuvant-induced inflammation could affect drug metabolism in liver. Here we further investigated the effect of inflammation on drug transport in liver using taurocholate as a model drug. The hepatic disposition kinetics of [3H]taurocholate in perfused normal and adjuvant-treated rat livers were investigated by the multiple indicator dilution technique and data were analyzed by a previously reported hepatobiliary taurocholate transport model. Real-time RT-PCR was also performed to determine the mRNA expression of liver bile salt transporters in normal and diseased livers. The uptake and biliary excretion of taurocholate were impaired in the adjuvant-treated rats as shown by decreased influx rate constant kin (0.65 ± 0.09 vs. 2.12 ± 0.30) and elimination rate constant kbe (0.09 ± 0.02 vs. 0.17 ± 0.04) compared with control rat group, whereas the efflux rate constant kout was greatly increased (0.07 ± 0.02 vs. 0.02 ± 0.01). The changes of mRNA expression of liver bile salt transporters were found in adjuvant-treated rats. Hepatic taurocholate extraction ratio in adjuvant-treated rats (0.86 ± 0.05, n = 6) was significantly reduced compared with 0.93 ± 0.05 ( n = 6) in normal rats. Hepatic extraction was well correlated with altered hepatic ATP content ( r2 = 0.90). In conclusion, systemic inflammation greatly affects hepatic ATP content/production and associated transporter activities and causes an impairment of transporter-mediated solute trafficking and pharmacokinetics.

The bound ligand effect in the complexation kinetics of some monoanionozinc(II) complexes with 1,10-phenanthroline

1978 ◽  
Vol 17 (10) ◽  
pp. 2790-2794 ◽  
Author(s):  
Shinkichi Yamada ◽  
Kiyomi Ohsumi ◽  
Motoharu Tanaka
Keyword(s):  
Ligand Effect ◽  
Kinetics Of ◽  
Complexation Kinetics

Acceleration of metal–ligand complexation kinetics by electrospray ionization

The Analyst ◽  
2017 ◽  
Vol 142 (23) ◽  
pp. 4468-4475 ◽  
Author(s):  
Morgan P. Kelley ◽  
Austen Davis ◽  
Brian Clowers ◽  
Aurora E. Clark ◽  
Sue B. Clark
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Formation Rate ◽  
Solution Phase ◽  
Ionization Mass ◽  
Order Of Magnitude ◽  
Kinetics Of ◽  
Metal Ligand ◽  
Complexation Kinetics

Electrospray ionization mass spectrometry (ESI-MS) is demonstrated to significantly accelerate the kinetics of metal–ligand complexation, with the formation rate constant increasing by more than an order of magnitude over previously determined solution-phase values.

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