scholarly journals How Do Ethanolamine Plasmalogens Contribute to Order and Structure of Neurological Membranes?

2020 ◽  
Vol 124 (5) ◽  
pp. 828-839 ◽  
Author(s):  
Ana West ◽  
Valeria Zoni ◽  
Walter E. Teague ◽  
Alison N. Leonard ◽  
Stefano Vanni ◽  
...  
Keyword(s):  
Ethanolamine Plasmalogens

scholarly journals Triple-Knockout, Synuclein-Free Mice Display Compromised Lipid Pattern

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3078
Author(s):  
Irina A. Guschina ◽  
Natalia Ninkina ◽  
Andrei Roman ◽  
Mikhail V. Pokrovskiy ◽  
Vladimir L. Buchman
Keyword(s):  
Fatty Acids ◽  
Lipid Metabolism ◽  
Family Members ◽  
Ether Lipid ◽  
Brain Regions ◽  
Membrane Lipid ◽  
Lipid Binding ◽  
Synaptic Functions ◽  
Ethanolamine Plasmalogens ◽  
Lipid Pattern

Recent studies have implicated synucleins in several reactions during the biosynthesis of lipids and fatty acids in addition to their recognised role in membrane lipid binding and synaptic functions. These are among aspects of decreased synuclein functions that are still poorly acknowledged especially in regard to pathogenesis in Parkinson’s disease. Here, we aimed to add to existing knowledge of synuclein deficiency (i.e., the lack of all three family members), with respect to changes in fatty acids and lipids in plasma, liver, and two brain regions in triple synuclein-knockout (TKO) mice. We describe changes of long-chain polyunsaturated fatty acids (LCPUFA) and palmitic acid in liver and plasma, reduced triacylglycerol (TAG) accumulation in liver and non-esterified fatty acids in plasma of synuclein free mice. In midbrain, we observed counterbalanced changes in the relative concentrations of phosphatidylcholine (PC) and cerebrosides (CER). We also recorded a notable reduction in ethanolamine plasmalogens in the midbrain of synuclein free mice, which is an important finding since the abnormal ether lipid metabolism usually associated with neurological disorders. In summary, our data demonstrates that synuclein deficiency results in alterations of the PUFA synthesis, storage lipid accumulation in the liver, and the reduction of plasmalogens and CER, those polar lipids which are principal compounds of lipid rafts in many tissues. An ablation of all three synuclein family members causes more profound changes in lipid metabolism than changes previously shown to be associated with γ-synuclein deficiency alone. Possible mechanisms by which synuclein deficiency may govern the reported modifications of lipid metabolism in TKO mice are proposed and discussed.

scholarly journals The Enzymic Synthesis of Ethanolamine Plasmalogens

1971 ◽  
Vol 246 (11) ◽  
pp. 3639-3645 ◽  
Author(s):  
Fred Snyder ◽  
M.L. Blank ◽  
Robert L. Wykle
Keyword(s):  
Enzymic Synthesis ◽  
Ethanolamine Plasmalogens

A novel antioxidant action of ethanolamine plasmalogens in lowering the oxidizability of membranes

2004 ◽  
Vol 32 (1) ◽  
pp. 141-143 ◽  
Author(s):  
R. Maeba ◽  
N. Ueta
Keyword(s):  
Free Radicals ◽  
Oxygen Uptake ◽  
Water Soluble ◽  
Antioxidant Action ◽  
Unilamellar Vesicles ◽  
Radical Initiator ◽  
Large Unilamellar Vesicles ◽  
Ethanolamine Plasmalogens ◽  
Uptake Method

We have demonstrated a novel antioxidant action of ethanolamine plasmalogens both in protecting cholesterol from oxidation by free radicals and in lowering the oxidizability of membranes, along with the action of scavenging radicals, by the oxygen-uptake method using large unilamellar vesicles and the water-soluble azo-radical initiator, AAPH [2,2´-azobis-(2-amidino-propane) dihydrochloride].

The Protective Effect of Dietary EPA‐Enriched Ethanolamine Plasmalogens against Hyperlipidemia in Aged Mice

2020 ◽  
Vol 122 (11) ◽  
pp. 2000179
Author(s):  
Lin Ding ◽  
Lingyu Zhang ◽  
Haohao Shi ◽  
Changhu Xue ◽  
Teruyoshi Yanagita ◽  
...  
Keyword(s):  
Protective Effect ◽  
Aged Mice ◽  
Ethanolamine Plasmalogens

MS/MS and LC-MS/MS analysis of choline/ethanolamine plasmalogens via promotion of alkali metal adduct formation

2015 ◽  
Vol 1004 ◽  
pp. 85-92 ◽  
Author(s):  
Yurika Otoki ◽  
Kiyotaka Nakagawa ◽  
Shunji Kato ◽  
Teruo Miyazawa
Keyword(s):  
Alkali Metal ◽  
Adduct Formation ◽  
Ms Analysis ◽  
Ethanolamine Plasmalogens

scholarly journals Homeostasis of phospholipids — The level of phosphatidylethanolamine tightly adapts to changes in ethanolamine plasmalogens

2015 ◽  
Vol 1851 (2) ◽  
pp. 117-128 ◽  
Author(s):  
Fabian Dorninger ◽  
Alexander Brodde ◽  
Nancy E. Braverman ◽  
Ann B. Moser ◽  
Wilhelm W. Just ◽  
...  
Keyword(s):  
Ethanolamine Plasmalogens

scholarly journals Triple-knockout, synuclein-free mice display compromised lipid pattern

2020 ◽  
Author(s):  
Irina Guschina ◽  
Natalia Ninkina ◽  
Andrei Y. Roman ◽  
Mikhail V. Pokrovskiy ◽  
Vladimir L. Buchman
Keyword(s):  
Fatty Acids ◽  
Lipid Metabolism ◽  
Lipid Membranes ◽  
Ether Lipid ◽  
Fatty Acid Analysis ◽  
Membrane Lipid ◽  
Lipid Binding ◽  
Synaptic Functions ◽  
Ethanolamine Plasmalogens ◽  
Lipid Pattern

Abstract Background: Recent studies have implicated synucleins in several reactions during the biosynthesis of lipids and fatty acids in addition to their recognised role in membrane lipid binding and synaptic functions. All members of the synuclein family interact robustly with lipid membranes, and appear to be important for the physiological functions of proteins while influencing the pathological aggregation of α-synuclein. Methods: The following tissues were used for lipid and fatty acid analysis: plasma, liver and two brain areas (cortex and midbrain). Lipid classes were separated using thin-layer chromatography. Fatty acids were analysed using gas chromatography. Results: We describe the importance of long-chain polyunsaturated fatty acids (LCPUFA) and palmitic acid in liver and plasma, reduced triacylglycerol (TAG) accumulation in liver and circulated plasma non-esterified fatty acids in synuclein free mice. In midbrain, observed changes in the relative concentrations of phosphatidylcholine (PC) and cerebrosides (CER) were counterbalanced. In midbrain, we recorded a notable reduction in ethanolamine plasmalogens in synuclein free mice and consider this an important finding considering the abnormal ether lipid metabolism usually associated with neurological disorders.Conclusions: In summary, our data demonstrate that synuclein deficiency can result in alterations of PUFA synthesis, storage lipid accumulation in liver, and reduction of plasmalogens and CER, those polar lipids which are principal compounds of lipid rafts in many tissues. An ablation of all three synuclein family members resulted in more pronounced lipid modifications then previously showed by us γ-synuclein deficiency. Possible mechanisms by which synuclein deficiency may govern the reported modifications of lipid metabolism in TKO mice are proposed and discussed.

Plasmalogens effectively reduce the surface tension of surfactant-like phospholipid mixtures

1998 ◽  
Vol 274 (1) ◽  
pp. L143-L148 ◽  
Author(s):  
M. Rüdiger ◽  
I. Kolleck ◽  
G. Putz ◽  
R. R. Wauer ◽  
P. Stevens ◽  
...  
Keyword(s):  
Surface Tension ◽  
Phase Behavior ◽  
Minimal Surface ◽  
Pulmonary Surfactant ◽  
Minor Components ◽  
Dipalmitoyl Phosphatidylcholine ◽  
Morphological Studies ◽  
Alveolar Surfactant ◽  
Plasmalogen Content ◽  
Ethanolamine Plasmalogens

The alkenyl-acyl subclass of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (plasmalogens) are minor components of alveolar surfactant. Plasmalogens promote and stabilize hexagonal structures of phospholipids. In another study (W. R. Perkins, R. B. Dause, R. A. Parente, S. R. Michey, K. C. Neuman, S. M. Gruner, T. F. Taraschi, and A. S. Janoff. Science 273: 330–332, 1996), it was shown that polymorphic phase behavior may have an important role in the effective functioning of pulmonary surfactant. Therefore, we hypothesized that surface properties of phospholipid mixtures that contain plasmalogens are superior to plasmalogen-free mixtures. The effect of plasmalogens on surface tension of surfactant-like phospholipid mixtures (70 mol% dipalmitoyl phosphatidylcholine, 10 mol% phosphatidylglycerol, and 20 mol% PtdEtn) was measured. Using the pulsating bubble surfactometer, we show that an increasing amount of ethanolamine plasmalogens [plasmenylethanolamine (PlsEtn)] results in reduction of surface tension (0 mol% PlsEtn 44.7 ± 1.7, 2 mol% 33.5 ± 1.7, 4 mol% 36 ± 3.1, 6 mol% 26.2 ± 2.9, and 8 mol% 22.2 ± 0.3 mN/m). By means of the captive bubble surfactometer, minimal surface tension reached with 8 mol% PlsEtn was even lower (3.8 ± 0.7 mN/m). With regard to morphological studies (B. Fringes, K. Gorgas, and A. Reith. Eur. J. Cell Biol. 46: 136–143, 1988), clofibrate treatment of rats might increase the plasmalogen content of alveolar surfactant. However, in the present study, we could not show that synthesis and secretion of plasmalogens are affected by clofibrate treatment.

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