Glassy Dynamics and Translational–Rotational Coupling of an Ionically Conducting Pharmaceutical Salt-Sodium Ibuprofen

2019 ◽  
Vol 123 (36) ◽  
pp. 7764-7770 ◽  
Author(s):  
K. P. Safna Hussan ◽  
Mohamed Shahin Thayyil ◽  
Ashna Poulose ◽  
K. L. Ngai
Keyword(s):  
Glassy Dynamics ◽  
Sodium Ibuprofen ◽  
Rotational Coupling

Assessment of Antithrombotic Properties of Sodium Ibuprofen

1982 ◽  
Vol 48 (01) ◽  
pp. 087-090 ◽  
Author(s):  
Carlos O Esquivel ◽  
David Bergqvist ◽  
Claes-Göran Björck ◽  
Stan N Carson ◽  
Bodil Nilsson
Keyword(s):  
Drug Administration ◽  
Platelet Function ◽  
Ex Vivo ◽  
Inhibitory Effect ◽  
Formation Time ◽  
Platelet Activity ◽  
Laser Injury ◽  
Sodium Ibuprofen ◽  
Plug Formation

SummaryThe effect of sodium ibuprofen on platelet activity in vivo and the lysability of ex vivo thrombi was investigated. The formation of a hemostatic platelet plug in the rabbit mesentery and platelet embolism as a response to a laser-induced injury in the ear chamber of rabbits were used as models for determining platelet activity. Ibuprofen at a dose of 25 mg/kg i.v. was found to increase the primary (PHT) and the total hemostatic plug formation time (THT). The same dose decreased the number of cumulative emboli over a 10 min period after a laser injury to arterioles. A dose of 10 mg/kg i.v. did not affect the formation of the hemostatic platelet plug. In dogs, doses of 10, 25 und 50 mg/kg did not enhance the release of 125I-FDP from the thrombi after incubation in plasmin, but the largest dose which is approximately five times the recommended dose in humans, did significantly decrease the thrombus weight 90 and 180 min after the drug administration. In conclusion, sodium ibuprofen was shown to have an inhibitory effect on platelet function in vivo and in large doses was also found to diminish the thrombus weight.

scholarly journals Glassy dynamics of sorbitol solutions at terahertz frequencies

2013 ◽  
Vol 15 (28) ◽  
pp. 11931 ◽  
Author(s):  
Juraj Sibik ◽  
Evgenyi Y. Shalaev ◽  
J. Axel Zeitler
Keyword(s):  
Glassy Dynamics ◽  
Terahertz Frequencies

scholarly journals Charge transport in DNA model with vibrational and rotational coupling motions

2017 ◽  
Vol 43 (3) ◽  
pp. 341-353 ◽  
Author(s):  
H. Ngoubi ◽  
G. H. Ben-Bolie ◽  
T. C. Kofané
Keyword(s):  
Charge Transport ◽  
Rotational Coupling

Predictive model for the composition dependence of glassy dynamics

2017 ◽  
Vol 101 (3) ◽  
pp. 1169-1179 ◽  
Author(s):  
Xiaoju Guo ◽  
John C. Mauro ◽  
Douglas C. Allan ◽  
Morten M. Smedskjaer
Keyword(s):  
Predictive Model ◽  
Composition Dependence ◽  
Glassy Dynamics

scholarly journals Entropy-Vanishing Transition and Glassy Dynamics in Frustrated Spins

2001 ◽  
Vol 86 (10) ◽  
pp. 2058-2061 ◽  
Author(s):  
Hui Yin ◽  
Bulbul Chakraborty
Keyword(s):  
Glassy Dynamics
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