Molecular-Level Insight into the Interactions of DNA/Polycation Complexes with Model Cell Membranes

2019 ◽  
Vol 123 (30) ◽  
pp. 6505-6514 ◽  
Author(s):  
Andrey A. Gurtovenko
Keyword(s):  
Cell Membranes ◽  
Molecular Level ◽  
Model Cell ◽  
Insight Into

Qualitative and Quantitative Analyses of the Molecular-Level Interaction between Memantine and Model Cell Membranes

2015 ◽  
Vol 119 (30) ◽  
pp. 17074-17083 ◽  
Author(s):  
Bolin Li ◽  
Hong-Yin Wang ◽  
Peiyong Feng ◽  
Xiaofeng Han ◽  
Zhan Chen ◽  
...  
Keyword(s):  
Cell Membranes ◽  
Molecular Level ◽  
Qualitative And Quantitative ◽  
Model Cell ◽  
Quantitative Analyses

scholarly journals Probing of Interactions of Magnetite Nanoparticles Coated with Native and Aminated Starch with a DPPC Model Membrane

2021 ◽  
Vol 22 (11) ◽  
pp. 5939
Author(s):  
Emilia Piosik ◽  
Aleksandra Zaryczniak ◽  
Kinga Mylkie ◽  
Marta Ziegler-Borowska
Keyword(s):  
Magnetite Nanoparticles ◽  
Targeted Drug Delivery ◽  
Cell Membranes ◽  
Molecular Level ◽  
Langmuir Monolayers ◽  
Disruptive Effect ◽  
Amino Groups ◽  
Coated Nanoparticles ◽  
Air Water Interface ◽  
Model Cell

Understanding the mechanism of interactions between magnetite nanoparticles and phospholipids that form cellular membranes at the molecular level is of crucial importance for their safe and effective application in medicine (e.g. magnetic resonance imaging, targeted drug delivery, and hyperthermia-based anticancer therapy). In these interactions, their surface coating plays a crucial role because even a small modification to its structure can cause significant changes to the behaviour of the magnetite nanoparticles that come in contact with a biomembrane. In this work, the influence of the magnetite nanoparticles functionalized with native and aminated starch on the thermodynamics, morphology, and dilatational elasticity of the model cell membranes was studied. The model cell membranes constituted the Langmuir monolayers formed at the air–water interface of dipalmitoylphosphatidylcholine (DPPC). The surface of the aminated starch-coated nanoparticles was enriched in highly reactive amino groups, which allowed more effective binding of drugs and biomolecules suitable for specific nano–bio applications. The studies indicated that the presence of these groups also reduced to some extent the disruptive effect of the magnetite nanoparticles on the model membranes and improved their adsorption.

scholarly journals Noni fruit’s water spot appearance on the second day of harvest: a trade-off between resistance and energy

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Tian Wu ◽  
Danyan Hu ◽  
Qingfen Wang
Keyword(s):  
Statistical Analysis ◽  
Molecular Level ◽  
Morinda Citrifolia ◽  
Transcriptome Data ◽  
Trade Off ◽  
Kegg Pathways ◽  
Available Energy ◽  
Climacteric Fruit ◽  
The Relationship ◽  
Insight Into

Abstract Background Noni (Morinda citrifolia Linn.) is a tropical tree that bears climacteric fruit. Previous observations and research have shown that the second day (2 d) after harvest is the most important demarcation point when the fruit has the same appearance as the freshly picked fruit (0 d); however, they are beginning to become water spot appearance. We performed a conjoint analysis of metabolome and transcriptome data for noni fruit of 0 d and 2 d to reveal what happened to the fruit at the molecular level. Genes and metabolites were annotated to KEGG pathways and the co-annotated KEGG pathways were used as a statistical analysis. Results We found 25 pathways that were significantly altered at both metabolic and transcriptional levels, including a total of 285 differentially expressed genes (DEGs) and 11 differential metabolites through an integrative analysis of transcriptomics and metabolomics. The energy metabolism and pathways originating from phenylalanine were disturbed the most. The upregulated resistance metabolites and genes implied the increase of resistance and energy consumption in the postharvest noni fruit. Most genes involved in glycolysis were downregulated, further limiting the available energy. This lack of energy led noni fruit to water spot appearance, a prelude to softening. The metabolites and genes related to the resistance and energy interacted and restricted each other to keep noni fruit seemingly hard within two days after harvest, but actually the softening was already unstoppable. Conclusions This study provides a new insight into the relationship between the metabolites and genes of noni fruit, as well as a foundation for further clarification of the post-ripening mechanism in noni fruit.

scholarly journals Cisplatin under oriented external electric fields: A deeper insight into electrochemotherapy at the molecular level

2020 ◽  
Author(s):  
Li Zhang ◽  
Ya‐Ling Ye ◽  
Xiao‐Ling Zhang ◽  
Xiang‐Hui Li ◽  
Qiao‐Hong Chen ◽  
...  
Keyword(s):  
Electric Fields ◽  
Molecular Level ◽  
External Electric Fields ◽  
Insight Into

Elucidation of molecular interactions between lipid membranes and ionic liquids using model cell membranes

Soft Matter ◽  
2012 ◽  
Vol 8 (20) ◽  
pp. 5501 ◽  
Author(s):  
Seunghwan Jeong ◽  
Sung Ho Ha ◽  
Sang-Hyun Han ◽  
Min-Cheol Lim ◽  
Sun Min Kim ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Molecular Interactions ◽  
Lipid Membranes ◽  
Cell Membranes ◽  
Model Cell

Use of model cell membranes to demonstrate templated binding of vancomycin group antibiotics

1997 ◽  
pp. 2911-2917 ◽  
Author(s):  
Andrew C. Try ◽  
Gary J. Sharman ◽  
Robert J. Dancer ◽  
Ben Bardsley ◽  
Richard M. H. Entress ◽  
...  
Keyword(s):  
Cell Membranes ◽  
Model Cell ◽  
Vancomycin Group

Molecular Interactions Between Silver Nanoparticles and Model Cell Membranes

2018 ◽  
Vol 61 (9-11) ◽  
pp. 1148-1162 ◽  
Author(s):  
Peipei Hu ◽  
Xiaoxian Zhang ◽  
Yaoxin Li ◽  
Cayla Pichan ◽  
Zhan Chen
Keyword(s):  
Silver Nanoparticles ◽  
Molecular Interactions ◽  
Cell Membranes ◽  
Model Cell

scholarly journals Molecular-Level Insight into How Hydroxyl Groups Boost Catalytic Activity in CO2 Hydrogenation into Methanol

Chem ◽  
2018 ◽  
Vol 4 (3) ◽  
pp. 613-625 ◽  
Author(s):  
Yuhan Peng ◽  
Liangbing Wang ◽  
Qiquan Luo ◽  
Yun Cao ◽  
Yizhou Dai ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Molecular Level ◽  
Co2 Hydrogenation ◽  
Hydroxyl Groups ◽  
Insight Into

scholarly journals Insight into molecular-level interactions between imidazolium-based ionic liquids and cellulose combining NMR, SAXS and MD simulations

2019 ◽  
Vol 75 (a1) ◽  
pp. a268-a268
Author(s):  
Aparna Annamraju ◽  
Nicholas D. Smith ◽  
Loukas Petridis ◽  
Hugh O'Neill ◽  
Sai Venkatesh Pingali ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Molecular Level ◽  
Md Simulations ◽  
Insight Into
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