scholarly journals Quantitative Kinetic Models from Intravital Microscopy: A Case Study Using Hepatic Transport

2019 ◽  
Vol 123 (34) ◽  
pp. 7302-7312 ◽  
Author(s):  
Meysam Tavakoli ◽  
Konstantinos Tsekouras ◽  
Richard Day ◽  
Kenneth W. Dunn ◽  
Steve Pressé
Keyword(s):  
Intravital Microscopy ◽  
Kinetic Models ◽  
Hepatic Transport

Kinetic models to improve the interpretation of the hepatic transport of 99mTc-mebrofenin

2020 ◽  
Vol 44 (2) ◽  
pp. 117-118
Author(s):  
S. Marie ◽  
L. Breuil ◽  
I. Hernàndez Lozano ◽  
M. Goislard ◽  
W. Saba ◽  
...  
Keyword(s):  
Kinetic Models ◽  
Hepatic Transport

Quantitative intravital microscopy of hepatic transport

IntraVital ◽  
2012 ◽  
Vol 1 (1) ◽  
pp. 44-53 ◽  
Author(s):  
Clifford M. Babbey ◽  
Jennifer C. Ryan ◽  
Erin M. Gill ◽  
Marwan S. Ghabril ◽  
Courtney R. Burch ◽  
...  
Keyword(s):  
Intravital Microscopy ◽  
Hepatic Transport

scholarly journals Effects of chronic kidney disease on liver transport: quantitative intravital microscopy of fluorescein transport in the rat liver

2014 ◽  
Vol 307 (12) ◽  
pp. R1488-R1492 ◽  
Author(s):  
Jennifer C. Ryan ◽  
Kenneth W. Dunn ◽  
Brian S. Decker
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Intravital Microscopy ◽  
Drug Transport ◽  
Cultured Cells ◽  
Organic Anion ◽  
Hepatic Clearance ◽  
Bile Canaliculi ◽  
Hepatic Transport

Clinical studies indicate that hepatic drug transport may be altered in chronic kidney disease (CKD). Uremic solutes associated with CKD have been found to alter the expression and/or activity of hepatocyte transporters in experimental animals and in cultured cells. However, given the complexity and adaptability of hepatic transport, it is not clear whether these changes translate into significant alterations in hepatic transport in vivo. To directly measure the effect of CKD on hepatocyte transport in vivo, we conducted quantitative intravital microscopy of transport of the fluorescent organic anion fluorescein in the livers of rats following 5/6th nephrectomy, an established model of CKD. Our quantitative analysis of fluorescein transport showed that the rate of hepatocyte uptake was reduced by ∼20% in 5/6th nephrectomized rats, consistent with previous observations of Oatp downregulation. However, the overall rate of transport into bile canaliculi was unaffected, suggesting compensatory changes in Mrp2-mediated secretion. Our study suggests that uremia resulting from 5/6th nephrectomy does not significantly impact the overall hepatic clearance of an Oatp substrate.

The Genesis and Internal Dynamics of El Salvador's People's Revolutionary Army, 1970–1976

2014 ◽  
Vol 38 (01) ◽  
pp. 102-129
Author(s):  
ALBERTO MARTÍN ÁLVAREZ ◽  
EUDALD CORTINA ORERO
Keyword(s):  
Latin America ◽  
El Salvador ◽  
Early Years ◽  
Left Wing ◽  
Internal Dynamics ◽  
Internal Coherence ◽  
The 1960S

AbstractUsing interviews with former militants and previously unpublished documents, this article traces the genesis and internal dynamics of the Ejército Revolucionario del Pueblo (People's Revolutionary Army, ERP) in El Salvador during the early years of its existence (1970–6). This period was marked by the inability of the ERP to maintain internal coherence or any consensus on revolutionary strategy, which led to a series of splits and internal fights over control of the organisation. The evidence marshalled in this case study sheds new light on the origins of the armed Salvadorean Left and thus contributes to a wider understanding of the processes of formation and internal dynamics of armed left-wing groups that emerged from the 1960s onwards in Latin America.

Culture and the plasticity of perception

2020 ◽  
Vol 43 ◽  
Author(s):  
Michael Lifshitz ◽  
T. M. Luhrmann
Keyword(s):  
Cultural Context ◽  
Sensory Experience ◽  
Cultural Learning ◽  
The World

Abstract Culture shapes our basic sensory experience of the world. This is particularly striking in the study of religion and psychosis, where we and others have shown that cultural context determines both the structure and content of hallucination-like events. The cultural shaping of hallucinations may provide a rich case-study for linking cultural learning with emerging prediction-based models of perception.

Dual systems for all: Higher-order, role-based relational reasoning as a uniquely derived feature of human cognition

2019 ◽  
Vol 42 ◽  
Author(s):  
Daniel J. Povinelli ◽  
Gabrielle C. Glorioso ◽  
Shannon L. Kuznar ◽  
Mateja Pavlic
Keyword(s):  
Temporal Reasoning ◽  
Higher Order ◽  
Important Case ◽  
Human Cognition ◽  
Relational Reasoning ◽  
Dual Systems ◽  
First Order ◽  
Reasoning System ◽  
Role Based

Abstract Hoerl and McCormack demonstrate that although animals possess a sophisticated temporal updating system, there is no evidence that they also possess a temporal reasoning system. This important case study is directly related to the broader claim that although animals are manifestly capable of first-order (perceptually-based) relational reasoning, they lack the capacity for higher-order, role-based relational reasoning. We argue this distinction applies to all domains of cognition.

Sociocultural memory development research drives new directions in gadgetry science

2019 ◽  
Vol 42 ◽  
Author(s):  
Penny Van Bergen ◽  
John Sutton
Keyword(s):  
Episodic Memory ◽  
Autobiographical Memory ◽  
Developmental Psychology ◽  
Cross Cultural ◽  
Memory Development ◽  
Development Research ◽  
Cultural Research ◽  
New Directions ◽  
Cross Cultural Research

Abstract Sociocultural developmental psychology can drive new directions in gadgetry science. We use autobiographical memory, a compound capacity incorporating episodic memory, as a case study. Autobiographical memory emerges late in development, supported by interactions with parents. Intervention research highlights the causal influence of these interactions, whereas cross-cultural research demonstrates culturally determined diversity. Different patterns of inheritance are discussed.

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