Comprehensive Insight into the Protein–Surface Biomolecular Interactions on a Smart Material: Complex Formation between Poly(N-vinyl Caprolactam) and Heme Protein

2019 ◽  
Vol 123 (29) ◽  
pp. 6331-6344 ◽  
Author(s):  
Krishan Kumar ◽  
Ritu Yadav ◽  
Pannuru Venkatesu
Keyword(s):  
Complex Formation ◽  
Heme Protein ◽  
Smart Material ◽  
Biomolecular Interactions ◽  
Protein Surface ◽  
Insight Into

scholarly journals Setting an Upper Limit on the Myoglobin Iron(IV)Hydroxide pKa: Insight into Axial Ligand Tuning in Heme Protein Catalysis

2014 ◽  
Vol 136 (25) ◽  
pp. 9124-9131 ◽  
Author(s):  
Timothy H. Yosca ◽  
Rachel K. Behan ◽  
Courtney M. Krest ◽  
Elizabeth L. Onderko ◽  
Matthew C. Langston ◽  
...  
Keyword(s):  
Heme Protein ◽  
Axial Ligand ◽  
Upper Limit ◽  
Insight Into ◽  
Protein Catalysis

Vibration Response Studies of a Bi-Morph SMA Hybrid Composite Using 3D Laser Doppler Vibrometer

2020 ◽  
Author(s):  
Rupal Srivastava ◽  
Ranjeet Kumar ◽  
Bishakh Bhattacharya
Keyword(s):  
Laser Doppler Vibrometer ◽  
Smart Material ◽  
Laser Doppler ◽  
Operational Environment ◽  
Temperature Dependent ◽  
Reinforced Composite ◽  
Active Fiber Composites ◽  
Insight Into ◽  
Selection Of ◽  
Multiple Step

Abstract With the advancement in the field of morphing and adaptive structures, there has been a tremendous increase in the application of such systems in the civil and aerospace engineering, especially wherever space constraint and variable operational environment demand frequent changes in system configuration. The control of stiffness and hence dynamic response of such deployable structures can be achieved through smart material based actuation mechanisms such as shape memory alloys (SMA), and piezoelectric active fiber composites. Selection of appropriate smart material hinges on the requirements of the speed of actuation, actuator bandwidth, and force requirement. In this work, we study the vibration modes of a bi-morph SMA reinforced composite with controlled current input. The composite consists of two layers of SMA reinforcements with 0° and 90° orientation angles placed orthogonally in alternate plies. The temperatures of these layers are raised through Joule heating, first individually, and then followed by combined actuation, where the current supply is controlled using a programmable DC supply. As the material properties of SMA are temperature dependent, we observe thermal contraction and a resulting increase in laminate stiffness. The change of compliance at multiple step-input current contributes to variation in the natural frequency which is recorded using a 3D laser doppler vibrometer (LDV). This study gives us a deep insight into the application of SMA-based bimorph composites for active damping and vibration control subject to varying temperatures.

scholarly journals Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf

Structure ◽  
2016 ◽  
Vol 24 (9) ◽  
pp. 1599-1605 ◽  
Author(s):  
Matthias Zebisch ◽  
Verity A. Jackson ◽  
Yuguang Zhao ◽  
E. Yvonne Jones
Keyword(s):  
Complex Formation ◽  
Ternary Complex ◽  
Dual Mode ◽  
Ternary Complex Formation ◽  
Insight Into

scholarly journals Molecular tweezers target a protein–protein interface and thereby modulate complex formation

2016 ◽  
Vol 52 (98) ◽  
pp. 14141-14144 ◽  
Author(s):  
F. Trusch ◽  
K. Kowski ◽  
K. Bravo-Rodriguez ◽  
C. Beuck ◽  
A. Sowislok ◽  
...  
Keyword(s):  
Complex Formation ◽  
Protein Interaction ◽  
Protein Interface ◽  
Protein Surface ◽  
Molecular Tweezers ◽  
Protein Protein Interaction

Supramolecular binders select few residues on a protein surface and by their unique complexation mode disrupt a critical protein–protein interaction.

Hydrogen exchange studies. XIV. Kinetics and mechanism of base-catalyzed hydrogen exchange in 1,3-dinitrobenzene in aqueous dimethylformamide and relationship with σ-complex formation

1981 ◽  
Vol 59 (22) ◽  
pp. 3177-3187 ◽  
Author(s):  
Erwin Buncel ◽  
Allen W. Zabel
Keyword(s):  
Complex Formation ◽  
Rate Constants ◽  
Hydrogen Exchange ◽  
Equilibrium Constants ◽  
Medium Composition ◽  
Proton Exchange ◽  
Ion Concentrations ◽  
First Order ◽  
Order Rate ◽  
Insight Into

Kinetic data have been evaluated for hydrogen exchange in 1,3-dinitrobenzene (DNB), occurring at the 2-position, in dimethylformamide (DMF) – D2O mixtures containing deuteroxide ion. The pseudo first order rate constants for exchange, kobs, show inverse dependence on the initial DNB concentration, which can be quantitatively related to the extent of σ-complex formation in these systems. The profile for kobs as function of medium composition exhibits a maximum at ca. 70 mol% DMF, and εapp for σ-complex formation reaches a plateau at about the same medium composition. The equilibrium constants for σ-complex formation, Ke, are used to calculate the free, or uncomplexed, deuteroxide ion concentrations, which then allow one to calculate k2, the second order rate constants for exchange. The k2 values show a uniformly increasing tendency with increased DMF content. Correlations with medium basicity are examined, and the nature of the log k2 and log Ke vs. H− plots afford insight into the origin of the medium dependence of proton exchange. The results of the present study are consistent with the σ-complex being an unreactive form of the substrate towards exchange, which occurs via uncomplexed DNB present in small concentration. The study also rules out the possibility that the colored species present in these systems is the carbanion formed on deprotonation of DNB.

scholarly journals Structures of the Human GTPase MMAA and Vitamin B12-dependent Methylmalonyl-CoA Mutase and Insight into Their Complex Formation

2010 ◽  
Vol 285 (49) ◽  
pp. 38204-38213 ◽  
Author(s):  
D. Sean Froese ◽  
Grazyna Kochan ◽  
João R. C. Muniz ◽  
Xuchu Wu ◽  
Carina Gileadi ◽  
...  
Keyword(s):  
Complex Formation ◽  
Vitamin B12 ◽  
Insight Into

Dendronized Gold Nanoparticles as Carriers for gp160 (HIV-1) Peptides: Biophysical Insight into Complex Formation

Langmuir ◽  
2021 ◽  
Vol 37 (4) ◽  
pp. 1542-1550
Author(s):  
Zuzana Garaiova ◽  
Sopio Melikishvili ◽  
Sylwia Michlewska ◽  
Maksim Ionov ◽  
Elzbieta Pedziwiatr-Werbicka ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Complex Formation ◽  
Insight Into ◽  
Hiv 1

scholarly journals Heme-protein vibrational couplings in cytochrome c provide a dynamic link that connects the heme-iron and the protein surface

2012 ◽  
Vol 109 (23) ◽  
pp. 8896-8900 ◽  
Author(s):  
M. G. I. Galinato ◽  
J. G. Kleingardner ◽  
S. E. J. Bowman ◽  
E. E. Alp ◽  
J. Zhao ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Heme Protein ◽  
Heme Iron ◽  
Protein Surface ◽  
Dynamic Link
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